SQSTM1

Gene Symbol	SQSTM1
Entrez Gene	8878
Alt Symbol	A170, OSIL, PDB3, ZIP3, p60, p62, p62B
Species	Human
Gene Type	protein-coding
Description	sequestosome 1
Other Description	EBI3-associated protein of 60 kDa|EBI3-associated protein p60|EBIAP|oxidative stress induced like|phosphotyrosine independent ligand for the Lck SH2 domain p62|phosphotyrosine-independent ligand for the Lck SH2 domain of 62 kDa|sequestosome-1|ubiquitin-binding protein p62
Swissprots	Q13501 Q9BUV7 B3KUW5 A6NFN7 Q13446 Q9UEU1 Q9BVS6 B2R661
Accessions	AAC64516 EAW53786 EAW53787 Q13501 AI333228 AK025146 AK093109 AK094484 AK096241 AK096257 AK098077 BAG53577 AK226167 AK293509 BAG56993 AK304877 BAG65614 AK312451 BAG35358 BC000951 AAH00951 BC001874 AAH01874 BC003139 AAH03139 BC005857 BC017222 AAH17222 BC019111 AAH19111 BC050631 BI549805 BM800056 BU625974 DA541885 DC398116 DQ581944 DQ892878 ABM83804 EU176717 ABW03518 U41806 AAA93299 U46751 AAC52070 XM_011534683 XP_011532985 XM_011534684 XP_011532986 NM_001142298 NP_001135770 NM_001142299 NP_001135771 NM_003900 NP_003891
Function	Autophagy receptor that interacts directly with both the cargo to become degraded and an autophagy modifier of the MAP1 LC3 family. Required both for the formation and autophagic degradation of polyubiquitin-containing bodies, called ALIS (aggresome-like induced structures) and links ALIS to the autophagic machinery. Involved in midbody ring degradation. May regulate the activation of NFKB1 by TNF-alpha, nerve growth factor (NGF) and interleukin- 1. May play a role in titin/TTN downstream signaling in muscle cells. May regulate signaling cascades through ubiquitination. Adapter that mediates the interaction between TRAF6 and CYLD (By similarity). May be involved in cell differentiation, apoptosis, immune response and regulation of K(+) channels. {ECO:0000250, ECO:0000269|PubMed:10356400, ECO:0000269|PubMed:10747026, ECO:0000269|PubMed:11244088, ECO:0000269|PubMed:12471037, ECO:0000269|PubMed:15340068, ECO:0000269|PubMed:15802564, ECO:0000269|PubMed:15911346, ECO:0000269|PubMed:15953362
Subcellular Location	Cytoplasm. Late endosome. Lysosome. Cytoplasmic vesicle, autophagosome. Nucleus. Endoplasmic reticulum. Cytoplasm, P-body. Note=Sarcomere (By similarity). In cardiac muscles localizes to the sarcomeric band (By similarity). Commonly found in inclusion bodies containing polyubiquitinated protein aggregates. In neurodegenerative diseases, detected in Lewy bodies in Parkinson disease, neurofibrillary tangles in Alzheimer disease, and HTT aggregates in Huntington disease. In protein aggregate diseases of the liver, found in large amounts in Mallory bodies of alcoholic and nonalcoholic steatohepatitis, hyaline bodies in hepatocellular carcinoma, and in SERPINA1 aggregates. Enriched in Rosenthal fibers of pilocytic astrocytoma. In the cytoplasm, observed in both membrane-free ubiquitin- containing protein aggregates (sequestosomes) and membrane- surrounded autophagosomes. Colocalizes with TRIM13 in the perinuclear endoplasmic reticulum. Co-localizes with TRIM5 in the cytoplasmic bodies. {ECO
Tissue Specificity	Ubiquitously expressed. {ECO:0000269|PubMed:8650207}.
Top Pathways	Osteoclast differentiation

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Sequestosome 1 (SQSTM1), Human, ELISA Kit - SED198Hu from ARP American Research Products Category ELISA Kit Prices $720.00 Sizes 96 t Sensitivity 0.125ng/mL Range 0.312-20ng/mL

Sequestosome 1, ELISA Kit - MBS083227 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Sequestosome 1, ELISA Kit - MBS055329 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Sequestosome 1, ELISA Kit - MBS073514 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Sequestosome 1, ELISA Kit - MBS084547 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Sequestosome 1, ELISA Kit - MBS106639 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Sequestosome 1, ELISA Kit - MBS096670 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Sequestosome 1, ELISA Kit - MBS082111 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Sequestosome 1 (SQSTM1), ELISA Kit - MBS2022445 from MyBioSource Category ELISA Kit Prices $380.00, $565.00, $765.00, $3,130.00, $5,670.00 Sizes 24 -strip-wells, 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells Sensitivity The minimum detectable dose of SQSTM1 is typically less than 0.112ng/mL. The sensitivity of this assay, or Lower Limit of Detection (LLD) was defined as the lowest protein concentration that could be differentiated from zero. It was determined by adding two standard deviations to the mean optical density value of twenty zero standard replicates and calculating the corresponding concentration. Range 0.312-20ng/mL

ELISA Kit for Sequestosome 1 (SQSTM1) - SED198Hu from Uscn Life Science Inc. Category ELISA Kit Sensitivity The minimum detectable dose of this kit is typically less than 0.112ng/mL. Range 0.313-20ng/mL The standard curve concentrations used for the ELISA’s were 20ng/mL, 10ng/mL, 5ng/mL, 2.5ng/mL, 1.25ng/mL, 0.625ng/mL, 0.313ng/mL

ELISA Kit for Sequestosome 1 (SQSTM1) - SED198Hu from Cloud-clone Category ELISA Kit Sensitivity The minimum detectable dose of this kit is typically less than 0.112ng/mL. Range 0.313-20ng/mL The standard curve concentrations used for the ELISA's were 20ng/mL, 10ng/mL, 5ng/mL, 2.5ng/mL, 1.25ng/mL, 0.625ng/mL, 0.313ng/mL

Human SQSTM1 ELISA Kit (Sandwich ELISA) - LS-F6709 from LifeSpan Bioscience Category ELISA Kit Prices $720.00 Sizes 1 plate Sensitivity 0.112 ng/ml Range 0.313-20 ng/ml

Human Sequestosome 1 (SQSTM1) ELISA Kit - EKU07279 from Biomatik Category ELISA Kit Prices $735.00, $3,234.00, $5,880.00 Sizes 96 t, 5x96t, 10x96t Sensitivity 0.112 ng/mL Range 0.312-20 ng/mL

Human Sequestosome 1 ELISA Kit - abx153062 from Abbexa Category ELISA Kit Sensitivity 0.125 ng/ml Range 0.313 ng/ml - 20 ng/ml

Sequestosome 1 (SQSTM1), Human, ELISA Kit - DL-SQSTM1-Hu from ARP American Research Products Category ELISA Kit Prices $655.00 Sizes 96 t Range 0.312-20 ng/mL

Human SQSTM1 ELISA Kit - abx572413 from Abbexa Category ELISA Kit Sensitivity 0.125 ng/ml Range 0.313 ng/ml - 20 ng/ml

Human SQSTM1 ELISA Kit - E034685 from Biobool Category ELISA Kit

SQSTM1 ELISA Kit (Human) (OKCD00900) - OKCD00900 from Aviva Systems Biology Category ELISA Kit Prices $545.00 Sizes 96 wells Sensitivity < 0.112 ng/mL Range 0.312-20 ng/mL

anti-SQSTM1 / p62 antibody - ARG55040 from Arigo Biolaboratories Category ELISA Kit

anti-SQSTM1 / p62 antibody - ARG57395 from Arigo Biolaboratories Category ELISA Kit

anti-SQSTM1 / p62 antibody - ARG57285 from Arigo Biolaboratories Category ELISA Kit

anti-SQSTM1 / p62 phospho (Ser28) antibody - ARG52384 from Arigo Biolaboratories Category ELISA Kit

anti-SQSTM1 / p62 phospho (Thr269 / Ser272) antibody - ARG52385 from Arigo Biolaboratories Category ELISA Kit

anti-SQSTM1 / p62 antibody - ARG54989 from Arigo Biolaboratories Category ELISA Kit

Human Sequestosome-1 (SQSTM1) ELISA Kit - AE15140HU from ARP American Research Products Category ELISA Kit Prices $549.00 Sizes 96 t Sensitivity 0.112 ng/mL Range 0.312-20 ng/mL

Search more