SQSTM1

Gene Symbol	SQSTM1
Entrez Gene	8878
Alt Symbol	A170, OSIL, PDB3, ZIP3, p60, p62, p62B
Species	Human
Gene Type	protein-coding
Description	sequestosome 1
Other Description	EBI3-associated protein of 60 kDa|EBI3-associated protein p60|EBIAP|oxidative stress induced like|phosphotyrosine independent ligand for the Lck SH2 domain p62|phosphotyrosine-independent ligand for the Lck SH2 domain of 62 kDa|sequestosome-1|ubiquitin-binding protein p62
Swissprots	Q13501 Q9BUV7 B3KUW5 A6NFN7 Q13446 Q9UEU1 Q9BVS6 B2R661
Accessions	AAC64516 EAW53786 EAW53787 Q13501 AI333228 AK025146 AK093109 AK094484 AK096241 AK096257 AK098077 BAG53577 AK226167 AK293509 BAG56993 AK304877 BAG65614 AK312451 BAG35358 BC000951 AAH00951 BC001874 AAH01874 BC003139 AAH03139 BC005857 BC017222 AAH17222 BC019111 AAH19111 BC050631 BI549805 BM800056 BU625974 DA541885 DC398116 DQ581944 DQ892878 ABM83804 EU176717 ABW03518 U41806 AAA93299 U46751 AAC52070 XM_011534683 XP_011532985 XM_011534684 XP_011532986 NM_001142298 NP_001135770 NM_001142299 NP_001135771 NM_003900 NP_003891
Function	Autophagy receptor that interacts directly with both the cargo to become degraded and an autophagy modifier of the MAP1 LC3 family. Required both for the formation and autophagic degradation of polyubiquitin-containing bodies, called ALIS (aggresome-like induced structures) and links ALIS to the autophagic machinery. Involved in midbody ring degradation. May regulate the activation of NFKB1 by TNF-alpha, nerve growth factor (NGF) and interleukin- 1. May play a role in titin/TTN downstream signaling in muscle cells. May regulate signaling cascades through ubiquitination. Adapter that mediates the interaction between TRAF6 and CYLD (By similarity). May be involved in cell differentiation, apoptosis, immune response and regulation of K(+) channels. {ECO:0000250, ECO:0000269|PubMed:10356400, ECO:0000269|PubMed:10747026, ECO:0000269|PubMed:11244088, ECO:0000269|PubMed:12471037, ECO:0000269|PubMed:15340068, ECO:0000269|PubMed:15802564, ECO:0000269|PubMed:15911346, ECO:0000269|PubMed:15953362
Subcellular Location	Cytoplasm. Late endosome. Lysosome. Cytoplasmic vesicle, autophagosome. Nucleus. Endoplasmic reticulum. Cytoplasm, P-body. Note=Sarcomere (By similarity). In cardiac muscles localizes to the sarcomeric band (By similarity). Commonly found in inclusion bodies containing polyubiquitinated protein aggregates. In neurodegenerative diseases, detected in Lewy bodies in Parkinson disease, neurofibrillary tangles in Alzheimer disease, and HTT aggregates in Huntington disease. In protein aggregate diseases of the liver, found in large amounts in Mallory bodies of alcoholic and nonalcoholic steatohepatitis, hyaline bodies in hepatocellular carcinoma, and in SERPINA1 aggregates. Enriched in Rosenthal fibers of pilocytic astrocytoma. In the cytoplasm, observed in both membrane-free ubiquitin- containing protein aggregates (sequestosomes) and membrane- surrounded autophagosomes. Colocalizes with TRIM13 in the perinuclear endoplasmic reticulum. Co-localizes with TRIM5 in the cytoplasmic bodies. {ECO
Tissue Specificity	Ubiquitously expressed. {ECO:0000269|PubMed:8650207}.
Top Pathways	Osteoclast differentiation

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

SignalSilence ® SQSTM1/p62 siRNA I - 6394 from Cell Signaling Technology Category siRNA Prices $256.00 Sizes 300 µl (3 nmol) Species Reactivities Human

SignalSilence ® SQSTM1/p62 siRNA II - 6399 from Cell Signaling Technology Category siRNA Prices $256.00 Sizes 300 µl (3 nmol) Species Reactivities Human

SQSTM1 CRISPR/Cas9 KO Plasmid (h) - sc-400099 from Santa Cruz Biotechnology Category CRISPR Prices $345.00 Sizes 20 µg Species Reactivities Human

SQSTM1 HDR Plasmid (h) - sc-400099-HDR from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

SQSTM1 Double Nickase Plasmid (h) - sc-400099-NIC from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

SQSTM1 Double Nickase Plasmid (h2) - sc-400099-NIC-2 from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

SQSTM1 CRISPR Activation Plasmid (h) - sc-400099-ACT from Santa Cruz Biotechnology Category CRISPR Prices $345.00 Sizes 20 µg Species Reactivities Human

SQSTM1 CRISPR Activation Plasmid (h2) - sc-400099-ACT-2 from Santa Cruz Biotechnology Category CRISPR Prices $345.00 Sizes 20 µg Species Reactivities Human

SQSTM1 Lentiviral Activation Particles (h) - sc-400099-LAC from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

SQSTM1 Lentiviral Activation Particles (h2) - sc-400099-LAC-2 from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

SQSTM1 siRNA (h) - sc-29679 from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Human

SQSTM1 shRNA Plasmid (h) - sc-29679-SH from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Human

SQSTM1 shRNA (h) Lentiviral Particles - sc-29679-V from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Human

p62/SQSTM1 RNAi - H00008878-R01 from Novus Biologicals Category siRNA Prices $339.00, $399.00 Sizes 10 nmol, 20 nmol Species Reactivities Human

MISSION® esiRNA - EHU027651 from Sigma-Aldrich Category siRNA Prices $140.00, $250.00 Sizes 20 µg, 50 µg

CompoZr® Knockout ZFN Kit - CKOZFN1311 from Sigma-Aldrich Category ZFN Kit Prices $4,999.00 Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND1311 from Sigma-Aldrich Category ZFN Kit Prices $3,999.00 Sizes 1 kt

MISSION® 3′UTR Lenti GoClone™ - HUTR09321 from Sigma-Aldrich Category miRNA Prices $350.00 Sizes hutr09321

SQSTM1 siRNA (Human) - CRH5865 from Cohesion Biosciences Category siRNA Prices $340.00, $510.00 Sizes 15 nmol, 30 nmol Species Reactivities Human

SQSTM1 - MBS8237381 from MyBioSource Prices $365.00, $515.00 Sizes 15 nmol, 30 nmol Species Reactivities Human

Human SQSTM1 siRNA - orb266367 from Biorbyt Category siRNA Prices $485.00, $629.00 Sizes 15 nmol, 30 nmol Species Reactivities Human

SQSTM1 shRNA Plasmid (Human) - CHH5865 from Cohesion Biosciences Category siRNA Prices $500.00, $750.00 Sizes 150 µg, 300 µg Species Reactivities Human

SQSTM1 miRNA 3'UTR clone - MiUTR3H-04190 from Creative biogene Species Reactivities Human

SQSTM1 miRNA 3'UTR clone - MiUTR3H-04191 from Creative biogene Species Reactivities Human

SQSTM1 miRNA 3'UTR clone - MiUTR3H-04192 from Creative biogene Species Reactivities Human

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