SQSTM1

Gene Symbol SQSTM1
Entrez Gene 8878
Alt Symbol A170, OSIL, PDB3, ZIP3, p60, p62, p62B
Species Human
Gene Type protein-coding
Description sequestosome 1
Other Description EBI3-associated protein of 60 kDa|EBI3-associated protein p60|EBIAP|oxidative stress induced like|phosphotyrosine independent ligand for the Lck SH2 domain p62|phosphotyrosine-independent ligand for the Lck SH2 domain of 62 kDa|sequestosome-1|ubiquitin-binding protein p62
Swissprots Q13501 Q9BUV7 B3KUW5 A6NFN7 Q13446 Q9UEU1 Q9BVS6 B2R661
Accessions AAC64516 EAW53786 EAW53787 Q13501 AI333228 AK025146 AK093109 AK094484 AK096241 AK096257 AK098077 BAG53577 AK226167 AK293509 BAG56993 AK304877 BAG65614 AK312451 BAG35358 BC000951 AAH00951 BC001874 AAH01874 BC003139 AAH03139 BC005857 BC017222 AAH17222 BC019111 AAH19111 BC050631 BI549805 BM800056 BU625974 DA541885 DC398116 DQ581944 DQ892878 ABM83804 EU176717 ABW03518 U41806 AAA93299 U46751 AAC52070 XM_011534683 XP_011532985 XM_011534684 XP_011532986 NM_001142298 NP_001135770 NM_001142299 NP_001135771 NM_003900 NP_003891
Function Autophagy receptor that interacts directly with both the cargo to become degraded and an autophagy modifier of the MAP1 LC3 family. Required both for the formation and autophagic degradation of polyubiquitin-containing bodies, called ALIS (aggresome-like induced structures) and links ALIS to the autophagic machinery. Involved in midbody ring degradation. May regulate the activation of NFKB1 by TNF-alpha, nerve growth factor (NGF) and interleukin- 1. May play a role in titin/TTN downstream signaling in muscle cells. May regulate signaling cascades through ubiquitination. Adapter that mediates the interaction between TRAF6 and CYLD (By similarity). May be involved in cell differentiation, apoptosis, immune response and regulation of K(+) channels. {ECO:0000250, ECO:0000269|PubMed:10356400, ECO:0000269|PubMed:10747026, ECO:0000269|PubMed:11244088, ECO:0000269|PubMed:12471037, ECO:0000269|PubMed:15340068, ECO:0000269|PubMed:15802564, ECO:0000269|PubMed:15911346, ECO:0000269|PubMed:15953362
Subcellular Location Cytoplasm. Late endosome. Lysosome. Cytoplasmic vesicle, autophagosome. Nucleus. Endoplasmic reticulum. Cytoplasm, P-body. Note=Sarcomere (By similarity). In cardiac muscles localizes to the sarcomeric band (By similarity). Commonly found in inclusion bodies containing polyubiquitinated protein aggregates. In neurodegenerative diseases, detected in Lewy bodies in Parkinson disease, neurofibrillary tangles in Alzheimer disease, and HTT aggregates in Huntington disease. In protein aggregate diseases of the liver, found in large amounts in Mallory bodies of alcoholic and nonalcoholic steatohepatitis, hyaline bodies in hepatocellular carcinoma, and in SERPINA1 aggregates. Enriched in Rosenthal fibers of pilocytic astrocytoma. In the cytoplasm, observed in both membrane-free ubiquitin- containing protein aggregates (sequestosomes) and membrane- surrounded autophagosomes. Colocalizes with TRIM13 in the perinuclear endoplasmic reticulum. Co-localizes with TRIM5 in the cytoplasmic bodies. {ECO
Tissue Specificity Ubiquitously expressed. {ECO:0000269|PubMed:8650207}.
Top Pathways Osteoclast differentiation

SQSTM1-Over-expression-Lysate - LY10932a from Abgent, a WuXi AppTec company

Category Cell Lysate
Prices $325.00
Sizes 100 µg
Western blot analysis of his-tag SQSTM1 (arrow) using his tag antibody. 293 cell lysates (2 ug/lane) either nontransfected (Lane 1) or transiently transfected with the SQSTM1 gene

SQSTM1 293T Cell Transient Overexpression Lysate(Denatured) - H00008878-T01 from Acris Antibodies

Category Cell Lysate
Prices $320.00
Sizes 100 µl

SQSTM1 overexpression lysate - LY401285 from Acris Antibodies

Category Cell Lysate
Prices $280.00
Sizes 100 µg

SQSTM1 overexpression lysate - LY428020 from Acris Antibodies

Category Cell Lysate
Prices $280.00
Sizes 100 µg

SQSTM1 293 Cell Lysate - 401180 from ABBIOTEC

Category Cell Lysate
Prices $392.00
Sizes 100 µg

p62/SQSTM1 Overexpression Lysate (Native) - NBL1-16446 from Novus Biologicals

Category Cell Lysate
Prices $329.00
Sizes 100 µg
Western Blot: p62/SQSTM1 Overexpression Lysate (Adult Normal) [NBL1-16446] Left-Empty vector transfected control cell lysate (HEK293 cell lysate); Right -Over-expression Lysate for p62/SQSTM1.

SQSTM1 Over-expression Lysate Product - GWB-584643 from Genway Biotech

Category Cell Lysate
Prices $346.00
Sizes 100 µg
Species Human

p62/SQSTM1 Overexpression Lysate (Denatured) - H00008878-T01 from Novus Biologicals

Category Cell Lysate
Prices $279.00
Sizes 100 µl
Western Blot: p62/SQSTM1 Overexpression Lysate (Denatured) [H00008878-T01] - Lane 1: SQSTM1 transfected lysate ( 48.51 KDa)Lane 2: Non-transfected lysate.

p62/SQSTM1 Overexpression Lysate (Denatured) - H00008878-T02 from Novus Biologicals

Category Cell Lysate
Prices $299.00
Sizes 100 µl

SQSTM1-knockout Cell lysate - LC810279 from Acris Antibodies

Category Cell Lysate
Prices $495.00
Sizes 100 µg

Panoply™ Human SQSTM1 Knockdown Stable Cell Line - CSC-DC015131 from Creative biogene

Category Cell Line
Species Human

SQSTM1 Knockout Cell Line-HCT116 - CSC-RT1874 from Creative biogene

Category Cell Line
Species Human

SQSTM1 Knockout Cell Line-HeLa - CSC-RT1952 from Creative biogene

Category Cell Line
Species Human

SQSTM1 KO Cell Lysate-HEK293T - CLKO-1038 from Creative biogene

Category Cell Lysate

SQSTM1 KO Cell Lysate-HCT116 - CLKO-1728 from Creative biogene

Category Cell Lysate

SQSTM1 KO Cell Lysate-HeLa - CLKO-1809 from Creative biogene

Category Cell Lysate
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