DBI

Gene Symbol DBI
Entrez Gene 1622
Alt Symbol ACBD1, ACBP, CCK-RP, EP
Species Human
Gene Type protein-coding
Description diazepam binding inhibitor (GABA receptor modulator, acyl-CoA binding protein)
Other Description GABA receptor modulator|acyl coenzyme A binding protein|acyl-CoA-binding protein|acyl-Coenzyme A binding domain containing 1|cholecystokinin-releasing peptide, trypsin-sensitive|diazepam binding inhibitor (GABA receptor modulator, acyl-Coenzyme A binding protein)|diazepam-binding inhibitor|endozepine
Swissprots B8ZWD2 P07108 Q6IB48 B8ZWD6 B8ZWD7 Q9UCI8 P08869 Q53SQ7 Q4VWZ6
Accessions AAY14873 EAW95214 EAW95215 EAW95216 P07108 AA096224 AM000001 CAJ00736 BC006466 BC062996 AAH62996 BM768076 BP294452 BP318721 BU599304 CR456956 CAG33237 DA226476 FM213122 CAR82404 FM213123 CAR82405 FM213124 CAR82406 FM213125 CAR82407 FM213126 CAR82408 FM213127 CAR82409 FM213128 CAR82410 FM213129 CAR82411 FM213130 CAR82412 FM213131 CAR82414 HQ448654 ADQ33132 M14200 AAA52171 M15887 AAA35788 NM_001079862 NP_001073331 NM_001079863 NP_001073332 NM_001178017 NP_001171488 NM_001178041 NP_001171512 NM_001178042 NP_001171513 NM_001178043 NP_001171514 NM_001282633 NP_001269562 NM_001282634 NP_001269563 NM_001282635 NP_001269564 NM_001282636 NP_001269565 NM_020548 NP_065438 NR_104221
Function Binds medium- and long-chain acyl-CoA esters with very high affinity and may function as an intracellular carrier of acyl-CoA esters. It is also able to displace diazepam from the benzodiazepine (BZD) recognition site located on the GABA type A receptor. It is therefore possible that this protein also acts as a neuropeptide to modulate the action of the GABA receptor.
Subcellular Location Endoplasmic reticulum. Golgi apparatus. Note=Golgi localization is dependent on ligand binding.
Tissue Specificity Isoform 1 is ubiquitous, with a moderate expression level. Isoform 2 is ubiquitous with high level in liver and adipose tissue. Isoform 3 is ubiquitous with strong expression in adipose tissue and heart. {ECO:0000269|PubMed:16055366, ECO:0000269|PubMed:21698759}.
Top Pathways PPAR signaling pathway

ACBP (C-9) - sc-376853 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
ACBP (C-9): sc-376853. Western blot analysis of ACBP expression in non-transfected: sc-117752 (A) and human ACBP transfected: sc-116768 (B) 293T whole cell lysates.

ACBP (FL-87) - sc-30190 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
ACBP (FL-87): sc-30190. Immunofluorescence staining of normal mouse intestine frozen section showing cytoplasmic and extracellular staining.

ACBP (M-20) - sc-23476 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
ACBP (M-20): sc-23476. Immunoperoxidase staining of formalin fixed, paraffin-embedded human prostate tissue showing cytoplasmic and membrane staining of glandular cells.

ACBP (W-20) - sc-23472 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

ACBP (C-19) - sc-23473 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

Anti-Diazepam Binding Inhibitor antibody - ab196485 from Abcam

Prices $370.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
All lanes : Anti-Diazepam Binding Inhibitor antibody (ab196485) at 1/500 dilutionLane 1 : HT29 cell extractLane 2 : THP1 cell extractLane 3 : MCF7 cell extractLane 4 : H460 cell extractLane 5 : A673 cell extractLane 6 : U937 cell extractLane 7 : U251 cell extract

Anti-Diazepam Binding Inhibitor antibody - ab134277 from Abcam

Prices $407.00
Sizes 50 µl
Host Rabbit
Clonality Polyclonal
Immunohistochemical analysis of paraffin-embedded Human spleen (lymphocytes) tissue labelling Diazepam Binding Inhibitor with ab134277 at 1/400. Primary incubation was followed by biotinylated goat anti-rabbit IgG secondary antibody, alkaline phosphatase-streptavidin and chromogen.

Anti-Diazepam Binding Inhibitor antibody - ab16871 from Abcam

Prices $370.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Anti-Diazepam Binding Inhibitor antibody [20B10] - ab16775 from Abcam

Prices $370.00
Sizes 100 µl
Host Mouse
Clonality Monoclonal
Clone 20B10
Overlay histogram showing HepG2 cells stained with ab16775 (red line). The cells were fixed with 4% paraformaldehyde (10 min) and then permeabilized with 0.1% PBS-Tween for 20 min. The cells were then incubated in 1x PBS / 10% normal goat serum / 0.3M glycine to block non-specific protein-protein interactions followed by the antibody (ab16675, 0.1μg/1x106 cells) for 30 min at 22°C. The secondary antibody used was Alexa Fluor® 488 goat anti-mouse IgG (H&L) (ab150113) at 1/2000 dilution for 30 min at 22°C. Isotype control antibody (black line) was mouse IgG1 [ICIGG1] (ab91353, 1μg/1x106 cells) used under the same conditions. Unlabelled sample (blue line) was also used as a control. Acquisition of >5,000 events were collected using a 20mW Argon ion laser (488nm) and 525/30 bandpass filter. This antibody gave a positive signal in HepG2 cells fixed with 80% methanol (5 min)/permeabilized with 0.1% PBS-Tween for 20 min used under the same conditions.

Anti-Diazepam Binding Inhibitor antibody [27C9] - ab16806 from Abcam

Prices $370.00
Sizes 100 µl
Host Mouse
Clonality Monoclonal
Clone 27C9

Anti-Diazepam Binding Inhibitor antibody - C-terminal - ab190646 from Abcam

Prices $370.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Anti-Diazepam Binding Inhibitor antibody - C-terminal (ab190646) at 1/500 dilution + MCF7 cell extract at 30 µg

Anti-DBI / ACBD1 Antibody (N-Terminus) IHC-plus™ - LS-B6783 from LifeSpan Bioscience

Prices $450.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Anti-DBI antibody IHC of human brain, cerebellum. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody LS-B6783 concentration 5 ug/ml.

Anti-DBI / ACBD1 Antibody (clone 20B10) IHC-plus™ - LS-B6257 from LifeSpan Bioscience

Prices $395.00
Sizes 50 µl
Host Mouse
Clonality Monoclonal
Clone 20B10
Anti-DBI antibody IHC of human small intestine. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody LS-B6257 dilution 1:200.

Anti-DBI / ACBD1 Antibody - LS-C334019 from LifeSpan Bioscience

Prices $255.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Immunofluorescence analysis of MCF-7 cell using DBI antibody. Blue: DAPI for nuclear staining.

Anti-DBI / ACBD1 Antibody - LS-C123397 from LifeSpan Bioscience

Prices $475.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal

Anti-DBI / ACBD1 Antibody - LS-C128606 from LifeSpan Bioscience

Prices $475.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal

Anti-DBI / ACBD1 Antibody (clone 20B10) - LS-C194695 from LifeSpan Bioscience

Prices $445.00
Sizes 100 µl
Host Mouse
Clonality Monoclonal
Clone 20B10

Anti-DBI / ACBD1 Antibody (clone 27C9) - LS-C194696 from LifeSpan Bioscience

Prices $445.00
Sizes 100 µl
Host Mouse
Clonality Monoclonal
Clone 27C9

Anti-DBI / ACBD1 Antibody (N-Terminus) - LS-C146261 from LifeSpan Bioscience

Prices $365.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
DBI antibody LS-C146261 Western blot of HT1080 Cell lysate. Antibody concentration 1 ug/ml.

Anti-DBI / ACBD1 Antibody (aa25-74) - LS-C291659 from LifeSpan Bioscience

Prices $315.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-DBI / ACBD1 Antibody (aa1-87) - LS-C294124 from LifeSpan Bioscience

Prices $405.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-DBI / ACBD1 Antibody (aa1-87, Biotin) - LS-C299614 from LifeSpan Bioscience

Prices $435.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-DBI / ACBD1 Antibody (aa1-87, FITC) - LS-C302454 from LifeSpan Bioscience

Prices $455.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-DBI / ACBD1 Antibody (aa2-87, Biotin) - LS-C299619 from LifeSpan Bioscience

Prices $435.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-DBI / ACBD1 Antibody (aa2-87, FITC) - LS-C302459 from LifeSpan Bioscience

Prices $465.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
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