| Gene Symbol |
DBI
|
| Entrez Gene |
1622
|
| Alt Symbol |
ACBD1, ACBP, CCK-RP, EP
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
diazepam binding inhibitor (GABA receptor modulator, acyl-CoA binding protein)
|
| Other Description |
GABA receptor modulator|acyl coenzyme A binding protein|acyl-CoA-binding protein|acyl-Coenzyme A binding domain containing 1|cholecystokinin-releasing peptide, trypsin-sensitive|diazepam binding inhibitor (GABA receptor modulator, acyl-Coenzyme A binding protein)|diazepam-binding inhibitor|endozepine
|
| Swissprots |
B8ZWD2 P07108 Q6IB48 B8ZWD6 B8ZWD7 Q9UCI8 P08869 Q53SQ7 Q4VWZ6
|
| Accessions |
AAY14873 EAW95214 EAW95215 EAW95216 P07108 AA096224 AM000001 CAJ00736 BC006466 BC062996 AAH62996 BM768076 BP294452 BP318721 BU599304 CR456956 CAG33237 DA226476 FM213122 CAR82404 FM213123 CAR82405 FM213124 CAR82406 FM213125 CAR82407 FM213126 CAR82408 FM213127 CAR82409 FM213128 CAR82410 FM213129 CAR82411 FM213130 CAR82412 FM213131 CAR82414 HQ448654 ADQ33132 M14200 AAA52171 M15887 AAA35788 NM_001079862 NP_001073331 NM_001079863 NP_001073332 NM_001178017 NP_001171488 NM_001178041 NP_001171512 NM_001178042 NP_001171513 NM_001178043 NP_001171514 NM_001282633 NP_001269562 NM_001282634 NP_001269563 NM_001282635 NP_001269564 NM_001282636 NP_001269565 NM_020548 NP_065438 NR_104221
|
| Function |
Binds medium- and long-chain acyl-CoA esters with very high affinity and may function as an intracellular carrier of acyl-CoA esters. It is also able to displace diazepam from the benzodiazepine (BZD) recognition site located on the GABA type A receptor. It is therefore possible that this protein also acts as a neuropeptide to modulate the action of the GABA receptor.
|
| Subcellular Location |
Endoplasmic reticulum. Golgi apparatus. Note=Golgi localization is dependent on ligand binding.
|
| Tissue Specificity |
Isoform 1 is ubiquitous, with a moderate expression level. Isoform 2 is ubiquitous with high level in liver and adipose tissue. Isoform 3 is ubiquitous with strong expression in adipose tissue and heart. {ECO:0000269|PubMed:16055366, ECO:0000269|PubMed:21698759}.
|
| Top Pathways |
PPAR signaling pathway
|
![Western Blot: ACBP Overexpression Lysate (Adult Normal) [NBL1-09728] Left-Empty vector transfected control cell lysate (HEK293 cell lysate); Right -Over-expression Lysate for ACBP.](http://www.bioprodhub.com/system/product_images/cel_products/5/sub_2/9258_ACBP%2520Overexpression%2520Lysate%2520(Adult%2520Normal)-Western%2520Blot-NBL1-09728-img0002.jpg)