| Gene Symbol |
PDCD10
|
| Entrez Gene |
11235
|
| Alt Symbol |
CCM3, TFAR15
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
programmed cell death 10
|
| Other Description |
TF-1 cell apoptosis-related protein 15|apoptosis-related protein 15|cerebral cavernous malformations 3 protein|programmed cell death protein 10
|
| Swissprots |
O14811 D3DNN5 A8K515 Q9BUL8
|
| Accessions |
EAW78574 EAW78575 EAW78576 EAW78577 EAW78578 EAW78579 EAW78580 EAW78581 Q9BUL8 AF022385 AAB72225 AK291130 BAF83819 BC002506 AAH02506 BC016353 AAH16353 CR457107 CAG33388 DQ892583 ABM83509 DQ895799 ABM86725 XM_005247086 XP_005247143 XM_005247087 XP_005247144 XM_005247088 XP_005247145 XM_006713485 XP_006713548 XM_011512368 XP_011510670 XM_011512369 XP_011510671 XM_011512370 XP_011510672 NM_007217 NP_009148 NM_145859 NP_665858 NM_145860 NP_665859
|
| Function |
Promotes cell proliferation. Modulates apoptotic pathways. Increases mitogen-activated protein kinase activity and STK26 activity. Important for cell migration, and for normal structure and assembly of the Golgi complex. Important for KDR/VEGFR2 signaling. Increases the stability of KDR/VEGFR2 and prevents its breakdown. Required for normal cardiovascular development. Required for normal angiogenesis, vasculogenesis and hematopoiesis during embryonic development (By similarity). {ECO:0000250}.
|
| Subcellular Location |
Cytoplasm. Golgi apparatus membrane; Peripheral membrane protein; Cytoplasmic side. Cell membrane; Peripheral membrane protein; Cytoplasmic side. Note=Partially co- localizes with endogenous PXN at the leading edges of migrating cells.
|
| Tissue Specificity |
Ubiquitous. {ECO:0000269|PubMed:15543491}.
|