| Gene Symbol | PDCD10 |
|---|---|
| Entrez Gene | 11235 |
| Alt Symbol | CCM3, TFAR15 |
| Species | Human |
| Gene Type | protein-coding |
| Description | programmed cell death 10 |
| Other Description | TF-1 cell apoptosis-related protein 15|apoptosis-related protein 15|cerebral cavernous malformations 3 protein|programmed cell death protein 10 |
| Swissprots | O14811 D3DNN5 A8K515 Q9BUL8 |
| Accessions | EAW78574 EAW78575 EAW78576 EAW78577 EAW78578 EAW78579 EAW78580 EAW78581 Q9BUL8 AF022385 AAB72225 AK291130 BAF83819 BC002506 AAH02506 BC016353 AAH16353 CR457107 CAG33388 DQ892583 ABM83509 DQ895799 ABM86725 XM_005247086 XP_005247143 XM_005247087 XP_005247144 XM_005247088 XP_005247145 XM_006713485 XP_006713548 XM_011512368 XP_011510670 XM_011512369 XP_011510671 XM_011512370 XP_011510672 NM_007217 NP_009148 NM_145859 NP_665858 NM_145860 NP_665859 |
| Function | Promotes cell proliferation. Modulates apoptotic pathways. Increases mitogen-activated protein kinase activity and STK26 activity. Important for cell migration, and for normal structure and assembly of the Golgi complex. Important for KDR/VEGFR2 signaling. Increases the stability of KDR/VEGFR2 and prevents its breakdown. Required for normal cardiovascular development. Required for normal angiogenesis, vasculogenesis and hematopoiesis during embryonic development (By similarity). {ECO:0000250}. |
| Subcellular Location | Cytoplasm. Golgi apparatus membrane; Peripheral membrane protein; Cytoplasmic side. Cell membrane; Peripheral membrane protein; Cytoplasmic side. Note=Partially co- localizes with endogenous PXN at the leading edges of migrating cells. |
| Tissue Specificity | Ubiquitous. {ECO:0000269|PubMed:15543491}. |