Gene Symbol | PDCD10 |
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Entrez Gene | 11235 |
Alt Symbol | CCM3, TFAR15 |
Species | Human |
Gene Type | protein-coding |
Description | programmed cell death 10 |
Other Description | TF-1 cell apoptosis-related protein 15|apoptosis-related protein 15|cerebral cavernous malformations 3 protein|programmed cell death protein 10 |
Swissprots | O14811 D3DNN5 A8K515 Q9BUL8 |
Accessions | EAW78574 EAW78575 EAW78576 EAW78577 EAW78578 EAW78579 EAW78580 EAW78581 Q9BUL8 AF022385 AAB72225 AK291130 BAF83819 BC002506 AAH02506 BC016353 AAH16353 CR457107 CAG33388 DQ892583 ABM83509 DQ895799 ABM86725 XM_005247086 XP_005247143 XM_005247087 XP_005247144 XM_005247088 XP_005247145 XM_006713485 XP_006713548 XM_011512368 XP_011510670 XM_011512369 XP_011510671 XM_011512370 XP_011510672 NM_007217 NP_009148 NM_145859 NP_665858 NM_145860 NP_665859 |
Function | Promotes cell proliferation. Modulates apoptotic pathways. Increases mitogen-activated protein kinase activity and STK26 activity. Important for cell migration, and for normal structure and assembly of the Golgi complex. Important for KDR/VEGFR2 signaling. Increases the stability of KDR/VEGFR2 and prevents its breakdown. Required for normal cardiovascular development. Required for normal angiogenesis, vasculogenesis and hematopoiesis during embryonic development (By similarity). {ECO:0000250}. |
Subcellular Location | Cytoplasm. Golgi apparatus membrane; Peripheral membrane protein; Cytoplasmic side. Cell membrane; Peripheral membrane protein; Cytoplasmic side. Note=Partially co- localizes with endogenous PXN at the leading edges of migrating cells. |
Tissue Specificity | Ubiquitous. {ECO:0000269|PubMed:15543491}. |
CCM3 CRISPR/Cas9 KO Plasmid (h) - sc-403858 from Santa Cruz Biotechnology
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CCM3 HDR Plasmid (h) - sc-403858-HDR from Santa Cruz Biotechnology
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CCM3 Double Nickase Plasmid (h) - sc-403858-NIC from Santa Cruz Biotechnology
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CCM3 Double Nickase Plasmid (h2) - sc-403858-NIC-2 from Santa Cruz Biotechnology
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CCM3 CRISPR Activation Plasmid (h) - sc-403858-ACT from Santa Cruz Biotechnology
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CCM3 CRISPR Activation Plasmid (h2) - sc-403858-ACT-2 from Santa Cruz Biotechnology
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CCM3 Lentiviral Activation Particles (h) - sc-403858-LAC from Santa Cruz Biotechnology
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CCM3 Lentiviral Activation Particles (h2) - sc-403858-LAC-2 from Santa Cruz Biotechnology
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CCM3 siRNA (h) - sc-62084 from Santa Cruz Biotechnology
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CCM3 shRNA Plasmid (h) - sc-62084-SH from Santa Cruz Biotechnology
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CCM3 shRNA (h) Lentiviral Particles - sc-62084-V from Santa Cruz Biotechnology
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MISSION® esiRNA - EHU139761 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN16514 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND16514 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR03954 from Sigma-Aldrich
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PDCD10 siRNA (Human) - CRH7700 from Cohesion Biosciences
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shRNA set against Human PDCD10 (NM_007217.3) - SHH372152 from Creative biogene
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shRNA set against Human PDCD10(NM_007217.3) - SHR098868 from Creative biogene
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Human PDCD10 siRNA - orb268202 from Biorbyt
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PDCD10 shRNA Plasmid (Human) - CHH7700 from Cohesion Biosciences
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PDCD10 miRNA 3'UTR clone - MiUTR1H-07693 from Creative biogene
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PDCD10 miRNA 3'UTR clone - MiUTR3H-10418 from Creative biogene
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PDCD10 miRNA 3'UTR clone - MiUTR3H-10419 from Creative biogene
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