| Gene Symbol |
ST3GAL2
|
| Entrez Gene |
6483
|
| Alt Symbol |
Gal-NAc6S, SIAT4B, ST3GALII, ST3GalA.2
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
ST3 beta-galactoside alpha-2,3-sialyltransferase 2
|
| Other Description |
CMP-N-acetylneuraminate-beta-galactosamide-alpha-2,3-sialyltransferase 2|Gal-beta-1,3-GalNAc-alpha-2,3-sialyltransferase|SIAT4-B|ST3Gal II|alpha 2,3-ST 2|beta-galactoside alpha-2,3-sialyltransferase 2|beta-galactoside alpha-2,3-sialytransferase|sialyltransferase 4B (beta-galactosidase alpha-2,3-sialytransferase)
|
| Swissprots |
O00654 Q16842
|
| Accessions |
CAS91689 EAW51818 EAW51819 EAW51820 EAW51821 Q16842 AF086257 AI933719 AK127322 BAG54481 AK313020 BAG35855 BC036777 AAH36777 BC064480 BI832366 JF432706 ADZ15923 U63090 AAB40389 X96667 CAA65447 NM_006927 NP_008858
|
| Function |
It may be responsible for the synthesis of the sequence NeuAc-alpha-2,3-Gal-beta-1,3-GalNAc- found in terminal carbohydrate groups of certain glycoproteins, oligosaccharides and glycolipids. SIAT4A and SIAT4B sialylate the same acceptor substrates but exhibit different Km values.
|
| Subcellular Location |
Golgi apparatus, Golgi stack membrane {ECO:0000250}; Single-pass type II membrane protein {ECO:0000250}. Secreted {ECO:0000250}. Note=Membrane-bound form in trans cisternae of Golgi. Secreted into the body fluid (By similarity). {ECO:0000250}.
|
| Tissue Specificity |
Highly expressed in skeletal muscle and heart and to a much lesser extent in brain, placenta, liver and pancreas. Scarcely detectable in lung and kidney. {ECO:0000269|PubMed:8920913, ECO:0000269|PubMed:9266697}.
|
| Top Pathways |
Mucin type O-Glycan biosynthesis, Glycosaminoglycan biosynthesis - keratan sulfate, Glycosphingolipid biosynthesis - globo series, Glycosphingolipid biosynthesis - ganglio series
|
