ST3GAL2
| Gene Symbol | ST3GAL2 |
|---|---|
| Entrez Gene | 6483 |
| Alt Symbol | Gal-NAc6S, SIAT4B, ST3GALII, ST3GalA.2 |
| Species | Human |
| Gene Type | protein-coding |
| Description | ST3 beta-galactoside alpha-2,3-sialyltransferase 2 |
| Other Description | CMP-N-acetylneuraminate-beta-galactosamide-alpha-2,3-sialyltransferase 2|Gal-beta-1,3-GalNAc-alpha-2,3-sialyltransferase|SIAT4-B|ST3Gal II|alpha 2,3-ST 2|beta-galactoside alpha-2,3-sialyltransferase 2|beta-galactoside alpha-2,3-sialytransferase|sialyltransferase 4B (beta-galactosidase alpha-2,3-sialytransferase) |
| Swissprots | O00654 Q16842 |
| Accessions | CAS91689 EAW51818 EAW51819 EAW51820 EAW51821 Q16842 AF086257 AI933719 AK127322 BAG54481 AK313020 BAG35855 BC036777 AAH36777 BC064480 BI832366 JF432706 ADZ15923 U63090 AAB40389 X96667 CAA65447 NM_006927 NP_008858 |
| Function | It may be responsible for the synthesis of the sequence NeuAc-alpha-2,3-Gal-beta-1,3-GalNAc- found in terminal carbohydrate groups of certain glycoproteins, oligosaccharides and glycolipids. SIAT4A and SIAT4B sialylate the same acceptor substrates but exhibit different Km values. |
| Subcellular Location | Golgi apparatus, Golgi stack membrane {ECO:0000250}; Single-pass type II membrane protein {ECO:0000250}. Secreted {ECO:0000250}. Note=Membrane-bound form in trans cisternae of Golgi. Secreted into the body fluid (By similarity). {ECO:0000250}. |
| Tissue Specificity | Highly expressed in skeletal muscle and heart and to a much lesser extent in brain, placenta, liver and pancreas. Scarcely detectable in lung and kidney. {ECO:0000269|PubMed:8920913, ECO:0000269|PubMed:9266697}. |
| Top Pathways | Mucin type O-Glycan biosynthesis, Glycosaminoglycan biosynthesis - keratan sulfate, Glycosphingolipid biosynthesis - globo series, Glycosphingolipid biosynthesis - ganglio series |
St3Gal-II CRISPR/Cas9 KO Plasmid (h) - sc-408013 from Santa Cruz Biotechnology
|
||||||||
St3Gal-II HDR Plasmid (h) - sc-408013-HDR from Santa Cruz Biotechnology
|
||||||||
St3Gal-II Double Nickase Plasmid (h) - sc-408013-NIC from Santa Cruz Biotechnology
|
||||||||
St3Gal-II Double Nickase Plasmid (h2) - sc-408013-NIC-2 from Santa Cruz Biotechnology
|
||||||||
St3Gal-II CRISPR Activation Plasmid (h) - sc-408013-ACT from Santa Cruz Biotechnology
|
||||||||
St3Gal-II CRISPR Activation Plasmid (h2) - sc-408013-ACT-2 from Santa Cruz Biotechnology
|
||||||||
St3Gal-II Lentiviral Activation Particles (h) - sc-408013-LAC from Santa Cruz Biotechnology
|
||||||||
St3Gal-II Lentiviral Activation Particles (h2) - sc-408013-LAC-2 from Santa Cruz Biotechnology
|
||||||||
St3Gal-II siRNA (h) - sc-93118 from Santa Cruz Biotechnology
|
||||||||
St3Gal-II shRNA Plasmid (h) - sc-93118-SH from Santa Cruz Biotechnology
|
||||||||
St3Gal-II shRNA (h) Lentiviral Particles - sc-93118-V from Santa Cruz Biotechnology
|
||||||||
ST3 beta-Gal alpha-2,3-Sialyltransferase 2/ST3GAL2 RNAi - H00006483-R02 from Novus Biologicals
|
||||||||
ST3 beta-Gal alpha-2,3-Sialyltransferase 2/ST3GAL2 RNAi - H00006483-R01 from Novus Biologicals
|
||||||||
MISSION® esiRNA - EHU077301 from Sigma-Aldrich
|
||||||||
CompoZr® Knockout ZFN Kit - CKOZFN20654 from Sigma-Aldrich
|
||||||||
CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND20654 from Sigma-Aldrich
|
||||||||
MISSION® 3′UTR Lenti GoClone™ - HUTR13228 from Sigma-Aldrich
|
||||||||
ST3GAL2 siRNA (Human) - CRH4382 from Cohesion Biosciences
|
||||||||
ST3GAL2 - MBS8237916 from MyBioSource
|
||||||||
shRNA set against Human ST3GAL2(NM_006927.3) - SHL037884 from Creative biogene
|
||||||||
ST3GAL2 shRNA Plasmid (Human) - CHH4382 from Cohesion Biosciences
|
||||||||
ST3GAL2 miRNA 3'UTR clone - MiUTR1H-09945 from Creative biogene
|