TDP1

Gene Symbol	TDP1
Entrez Gene	55775
Alt Symbol	-
Species	Human
Gene Type	protein-coding
Description	tyrosyl-DNA phosphodiesterase 1
Other Description	tyr-DNA phosphodiesterase 1
Swissprots	Q9NZM7 Q96BK7 Q9NZM8 Q2HXX4 Q9NUW8 Q86TV8
Accessions	ABC79301 CAC38574 EAW81414 EAW81415 EAW81416 Q9NUW8 AF182002 AAF65623 AF182003 AAF65624 AK001952 BAA91997 AK023514 BAG51203 AK093235 AK315549 BAG37927 AL832288 BC006083 AAH06083 BC015474 AAH15474 BC107877 AAI07878 BM661793 BU849335 BX161451 CAD61915 XM_005267847 XP_005267904 XM_005267848 XP_005267905 XM_006720197 XP_006720260 XM_006720198 XP_006720261 XM_006720199 XP_006720262 XM_006720200 XP_006720263 XM_011536941 XP_011535243 XM_011536942 XP_011535244 XM_011536943 XP_011535245 XM_011536944 XP_011535246 XR_943492 NM_001008744 NP_001008744 NM_018319 NP_060789
Function	DNA repair enzyme that can remove a variety of covalent adducts from DNA through hydrolysis of a 3'-phosphodiester bond, giving rise to DNA with a free 3' phosphate. Catalyzes the hydrolysis of dead-end complexes between DNA and the topoisomerase I active site tyrosine residue. Hydrolyzes 3'-phosphoglycolates on protruding 3' ends on DNA double-strand breaks due to DNA damage by radiation and free radicals. Acts on blunt-ended double-strand DNA breaks and on single-stranded DNA. Has low 3'exonuclease activity and can remove a single nucleoside from the 3'end of DNA and RNA molecules with 3'hydroxyl groups. Has no exonuclease activity towards DNA or RNA with a 3'phosphate. {ECO:0000269|PubMed:12023295, ECO:0000269|PubMed:15111055, ECO:0000269|PubMed:15811850, ECO:0000269|PubMed:16141202, ECO:0000269|PubMed:22822062}.
Subcellular Location	Nucleus {ECO:0000269|PubMed:15647511}. Cytoplasm {ECO:0000269|PubMed:15647511}.
Tissue Specificity	Ubiquitously expressed. Similar expression throughout the central nervous system (whole brain, amygdala, caudate nucleus, cerebellum, cerebral cortex, frontal lobe, hippocampus, medulla oblongata, occipital lobe, putamen, substantia nigra, temporal lobe, thalamus, nucleus accumbens and spinal cord) and increased expression in testis and thymus. {ECO:0000269|PubMed:12244316, ECO:0000269|PubMed:17948061}.

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Rabbit anti-TDP1 Antibody, Affinity Purified - PLA0198 from Sigma-Aldrich Prices $323.50 Sizes 100 µl

Tyrosyl-DNA Phosphodiesterase 1 (TDP1�__ELISA Kit, Human, ELISA Kit - CSB-E17810h from ARP American Research Products Category ELISA Kit Prices $495.00, $695.00, $696.00, $699.00 Sizes 48 t, 96 t, 5 x 96t, 10 x 96t

TDP1 (Human) IP-WB Antibody Pair - H00055775-PW1 from Acris Antibodies Category Antibody Pair Prices $610.00 Sizes 1 set

TDP1 (Human) Matched Antibody Pair - H00055775-AP11 from Acris Antibodies Category Antibody Pair Prices $610.00 Sizes 1 set

TDP1 (Human) Matched Antibody Pair - H00055775-AP51 from Acris Antibodies Category Antibody Pair Prices $610.00 Sizes 1 set

tyrosyl-DNA phosphodiesterase 1, ELISA Kit - MBS903465 from MyBioSource Category ELISA Kit Prices $250.00, $495.00, $710.00, $2,705.00, $5,145.00 Sizes 24 -strip-wells (Limit 1), 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells Sensitivity The minimum detectable dose of human TDP1 is typically less than 15.6 pg/ml. The sensitivity of this assay, or Lower Limit of Detection (LLD) was defined as the lowest protein concentration that could be differentiated from zero. It was determined the mean O.D value of 20 replicates of the zero standard added by their three standard deviations. Range 62.5 pg/ml-4000 pg/ml.

Human Tyrosyl-DNA Phosphodiesterase 1(TDP1）ELISA Kit - CSB-E17810h from Cusabio Category ELISA Kit Sensitivity 15.6pg/ml Range 62.5 pg/ml-4000 pg/ml

Human Tyrosyl-DNA Phosphodiesterase 1 (TDP1) ELISA Kit - EKC35968 from Biomatik Category ELISA Kit Prices $705.00, $2,820.00, $5,288.00 Sizes 96 t, 5x96t, 10x96t Sensitivity 15.6 pg/ml Range 62.5 pg/ml-4000 pg/ml

Human TDP1 ELISA Kit - E040189 from Biobool Category ELISA Kit Sensitivity The minimum detectable dose of human TDP1 is typically less than 15.6 pg/ml. The sensitivity of this assay, or Lower Limit of Detection (LLD) was defined as the lowest protein concentration that could be differentiated from zero. It was determined the mea

TDP1 ELISA Kit (Human) (OKCA02320) - OKCA02320 from Aviva Systems Biology Category ELISA Kit Sensitivity 15.6 pg/mL Range 62.5 - 4,000 pg/mL

Search more