TDP1

Gene Symbol TDP1
Entrez Gene 55775
Alt Symbol -
Species Human
Gene Type protein-coding
Description tyrosyl-DNA phosphodiesterase 1
Other Description tyr-DNA phosphodiesterase 1
Swissprots Q9NZM7 Q96BK7 Q9NZM8 Q2HXX4 Q9NUW8 Q86TV8
Accessions ABC79301 CAC38574 EAW81414 EAW81415 EAW81416 Q9NUW8 AF182002 AAF65623 AF182003 AAF65624 AK001952 BAA91997 AK023514 BAG51203 AK093235 AK315549 BAG37927 AL832288 BC006083 AAH06083 BC015474 AAH15474 BC107877 AAI07878 BM661793 BU849335 BX161451 CAD61915 XM_005267847 XP_005267904 XM_005267848 XP_005267905 XM_006720197 XP_006720260 XM_006720198 XP_006720261 XM_006720199 XP_006720262 XM_006720200 XP_006720263 XM_011536941 XP_011535243 XM_011536942 XP_011535244 XM_011536943 XP_011535245 XM_011536944 XP_011535246 XR_943492 NM_001008744 NP_001008744 NM_018319 NP_060789
Function DNA repair enzyme that can remove a variety of covalent adducts from DNA through hydrolysis of a 3'-phosphodiester bond, giving rise to DNA with a free 3' phosphate. Catalyzes the hydrolysis of dead-end complexes between DNA and the topoisomerase I active site tyrosine residue. Hydrolyzes 3'-phosphoglycolates on protruding 3' ends on DNA double-strand breaks due to DNA damage by radiation and free radicals. Acts on blunt-ended double-strand DNA breaks and on single-stranded DNA. Has low 3'exonuclease activity and can remove a single nucleoside from the 3'end of DNA and RNA molecules with 3'hydroxyl groups. Has no exonuclease activity towards DNA or RNA with a 3'phosphate. {ECO:0000269|PubMed:12023295, ECO:0000269|PubMed:15111055, ECO:0000269|PubMed:15811850, ECO:0000269|PubMed:16141202, ECO:0000269|PubMed:22822062}.
Subcellular Location Nucleus {ECO:0000269|PubMed:15647511}. Cytoplasm {ECO:0000269|PubMed:15647511}.
Tissue Specificity Ubiquitously expressed. Similar expression throughout the central nervous system (whole brain, amygdala, caudate nucleus, cerebellum, cerebral cortex, frontal lobe, hippocampus, medulla oblongata, occipital lobe, putamen, substantia nigra, temporal lobe, thalamus, nucleus accumbens and spinal cord) and increased expression in testis and thymus. {ECO:0000269|PubMed:12244316, ECO:0000269|PubMed:17948061}.

TDP1 (C-3) - sc-365674 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
TDP1 (C-3): sc-365674. Western blot analysis of TDP1 expression in Ramos whole cell lysate.

TDP1 (H-300) - sc-32924 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal

TDP1 (N-17) - sc-26038 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

TDP1 (C-15) - sc-26040 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
TDP1 (C-15): sc-26040. Immunoperoxidase staining of formalin fixed, paraffin-embedded human testis tissue showing nuclear and cytoplasmic staining of cells in seminiferous ducts and Leydig cells.

Anti-TDP1 antibody - ab4166 from Abcam

Prices $401.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Anti-TDP1 antibody (ab4166) at 1 µg/ml (blocked with 3% milk) + Jurkat (Human T cell lymphoblast-like cell line) Nuclear Lysate (ab14844) at 20 µgSecondaryGoat Anti-Rabbit IgG H&L (HRP) (ab97051) at 1/10000 dilutiondeveloped using the ECL techniquePerformed under reducing conditions.

Anti-TDP1 antibody - ab84747 from Abcam

Prices $376.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
ab84747 at 1/250 dilution staining TDP1 in human ovarian tumor by Immunohistochemistry, Formalin-fixed, Paraffin-embedded tissue. Detection: DAB staining.

Anti-TDP1 antibody - ab172712 from Abcam

Prices $376.00
Sizes 50 µg
Host Mouse
Clonality Polyclonal
All lanes : Anti-TDP1 antibody (ab172712) at 1 µg/mlLane 1 : TDP1 transfected 293T cell line lysateLane 2 : Non-transfected 293T cell line lysateLysates/proteins at 15 µl per lane.

Anti-TDP1 antibody - ab190302 from Abcam

Prices $376.00
Sizes 200 µl
Host Goat
Clonality Polyclonal
Anti-TDP1 antibody (ab190302) at 2 µg/ml + Jurkat nuclear lysate at 35 µgdeveloped using the ECL technique

Anti-TDP1 antibody [AT1F2] - ab91035 from Abcam

Prices $376.00
Sizes 50 µg
Host Mouse
Clonality Monoclonal
Clone AT1F2
Anti-TDP1 antibody [AT1F2] (ab91035) at 1/1000 dilution + MCF7 cell lysate at 30 µgSecondaryGoat anti-mouse secondary antibody conjugated to HRPdeveloped using the ECL technique

Anti-TDP1 Antibody (clone AT1F2) IHC-plus™ - LS-B3586 from LifeSpan Bioscience

Prices $395.00
Sizes 50 µl
Host Mouse
Clonality Monoclonal
Clone AT1F2
Anti-TDP1 antibody IHC of human placenta. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody LS-B3586 concentration 5 ug/ml.

Anti-TDP1 Antibody (aa1-298) - LS-C132776 from LifeSpan Bioscience

Prices $415.00
Sizes 100 µl
Host Mouse
Clonality Monoclonal

Anti-TDP1 Antibody (aa212-239, AP) - LS-C241675 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-TDP1 Antibody (aa212-239, FITC) - LS-C241678 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-TDP1 Antibody (aa212-239, Biotin) - LS-C241677 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-TDP1 Antibody (aa212-239, APC) - LS-C241676 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-TDP1 Antibody (aa212-239, PE) - LS-C241681 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-TDP1 Antibody (aa212-239, Azide-free, HRP) - LS-C247041 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-TDP1 Antibody (aa211-239) - LS-C325650 from LifeSpan Bioscience

Prices $345.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-TDP1 Antibody (aa75-125) - LS-C288408 from LifeSpan Bioscience

Prices $375.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Anti-TDP1 Antibody (aa1-298, clone AT1F2) - LS-C347591 from LifeSpan Bioscience

Prices $475.00
Sizes 50 µg
Host Mouse
Clonality Monoclonal
Clone AT1F2

Anti-TDP1 Antibody (aa350-399) - LS-C135430 from LifeSpan Bioscience

Prices $365.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
TDP1 antibody LS-C135430 Western blot of Mouse Brain lysate. Antibody concentration 1 ug/ml.

Anti-TDP1 Antibody (aa428-477) - LS-C201691 from LifeSpan Bioscience

Prices $365.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Western blot of Mouse Lung. Tdp1 antibody dilution 1.0 ug/ml.

Anti-TDP1 Antibody (clone 4H1) - LS-C337530 from LifeSpan Bioscience

Prices $350.00
Sizes 100 µl
Host Mouse
Clonality Monoclonal
Clone 4H1
HEK293T cells were transfected with the pCMV6-ENTRY control (Left lane) or pCMV6-ENTRY TDP1 (Right lane) cDNA for 48 hrs and lysed. Equivalent amounts of cell lysates (5 ug per lane) were separated by SDS-PAGE and immunoblotted with anti-TDP1.

Anti-TDP1 Antibody (aa212-239) - LS-C157164 from LifeSpan Bioscience

Prices $295.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
TDP1 Antibody western blot of mouse stomach tissue lysates (35 ug/lane). The TDP1 antibody detected the TDP1 protein (arrow).

Anti-TDP1 Antibody (aa1-50) - LS-C288407 from LifeSpan Bioscience

Prices $375.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Detection of Human TDP1 by Immunohistochemistry. Sample: FFPE section of human ovarian carcinoma. Antibody: Affinity purified rabbit anti-TDP1 used at a dilution of 1:1000 (0.2 ug/ml). Detection: DAB.
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