TDP1

Gene Symbol TDP1
Entrez Gene 55775
Alt Symbol -
Species Human
Gene Type protein-coding
Description tyrosyl-DNA phosphodiesterase 1
Other Description tyr-DNA phosphodiesterase 1
Swissprots Q9NZM7 Q96BK7 Q9NZM8 Q2HXX4 Q9NUW8 Q86TV8
Accessions ABC79301 CAC38574 EAW81414 EAW81415 EAW81416 Q9NUW8 AF182002 AAF65623 AF182003 AAF65624 AK001952 BAA91997 AK023514 BAG51203 AK093235 AK315549 BAG37927 AL832288 BC006083 AAH06083 BC015474 AAH15474 BC107877 AAI07878 BM661793 BU849335 BX161451 CAD61915 XM_005267847 XP_005267904 XM_005267848 XP_005267905 XM_006720197 XP_006720260 XM_006720198 XP_006720261 XM_006720199 XP_006720262 XM_006720200 XP_006720263 XM_011536941 XP_011535243 XM_011536942 XP_011535244 XM_011536943 XP_011535245 XM_011536944 XP_011535246 XR_943492 NM_001008744 NP_001008744 NM_018319 NP_060789
Function DNA repair enzyme that can remove a variety of covalent adducts from DNA through hydrolysis of a 3'-phosphodiester bond, giving rise to DNA with a free 3' phosphate. Catalyzes the hydrolysis of dead-end complexes between DNA and the topoisomerase I active site tyrosine residue. Hydrolyzes 3'-phosphoglycolates on protruding 3' ends on DNA double-strand breaks due to DNA damage by radiation and free radicals. Acts on blunt-ended double-strand DNA breaks and on single-stranded DNA. Has low 3'exonuclease activity and can remove a single nucleoside from the 3'end of DNA and RNA molecules with 3'hydroxyl groups. Has no exonuclease activity towards DNA or RNA with a 3'phosphate. {ECO:0000269|PubMed:12023295, ECO:0000269|PubMed:15111055, ECO:0000269|PubMed:15811850, ECO:0000269|PubMed:16141202, ECO:0000269|PubMed:22822062}.
Subcellular Location Nucleus {ECO:0000269|PubMed:15647511}. Cytoplasm {ECO:0000269|PubMed:15647511}.
Tissue Specificity Ubiquitously expressed. Similar expression throughout the central nervous system (whole brain, amygdala, caudate nucleus, cerebellum, cerebral cortex, frontal lobe, hippocampus, medulla oblongata, occipital lobe, putamen, substantia nigra, temporal lobe, thalamus, nucleus accumbens and spinal cord) and increased expression in testis and thymus. {ECO:0000269|PubMed:12244316, ECO:0000269|PubMed:17948061}.

TDP1 CRISPR/Cas9 KO Plasmid (h) - sc-405057 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

TDP1 HDR Plasmid (h) - sc-405057-HDR from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

TDP1 Double Nickase Plasmid (h) - sc-405057-NIC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

TDP1 Double Nickase Plasmid (h2) - sc-405057-NIC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

TDP1 CRISPR Activation Plasmid (h) - sc-405057-ACT from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

TDP1 CRISPR Activation Plasmid (h2) - sc-405057-ACT-2 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

TDP1 Lentiviral Activation Particles (h) - sc-405057-LAC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

TDP1 Lentiviral Activation Particles (h2) - sc-405057-LAC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

TDP1 siRNA (h) - sc-41056 from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

TDP1 shRNA Plasmid (h) - sc-41056-SH from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

TDP1 shRNA (h) Lentiviral Particles - sc-41056-V from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

TDP1 RNAi - H00055775-R02 from Novus Biologicals

Category siRNA
Prices $399.00
Sizes 20 nmol
Species Reactivities Human

MISSION® esiRNA - EHU094671 from Sigma-Aldrich

Category siRNA
Prices $140.00, $250.00
Sizes 20 µg, 50 µg

CompoZr® Knockout ZFN Kit - CKOZFN21183 from Sigma-Aldrich

Category ZFN Kit
Prices $4,999.00
Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND21183 from Sigma-Aldrich

Category ZFN Kit
Prices $3,999.00
Sizes 1 kt

MISSION® 3′UTR Lenti GoClone™ - HUTR10144 from Sigma-Aldrich

Category miRNA
Prices $350.00
Sizes hutr10144

TDP1 siRNA (Human) - CRJ0910 from Cohesion Biosciences

Category siRNA
Prices $340.00, $510.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

TDP1 RNAi - H00055775-R01 from Novus Biologicals

Category siRNA
Prices $399.00
Sizes 20 nmol
Species Reactivities Human

TDP1 - MBS8226487 from MyBioSource

Prices $365.00, $515.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

TDP1 CRISPR/Cas9 KO Plasmid (h2) - sc-405057-KO-2 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

TDP1 HDR Plasmid (h2) - sc-405057-HDR-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

shRNA set against Human TDP1 (NM_018319.3) - SHH425288 from Creative biogene

Category siRNA
Species Reactivities Human

shRNA set against Human TDP1(NM_001008744.1) - SHL063666 from Creative biogene

Category siRNA
Species Reactivities Human

Human TDP1 siRNA - orb271411 from Biorbyt

Category siRNA
Prices $485.00, $629.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

TDP1 shRNA Plasmid (Human) - CHJ0910 from Cohesion Biosciences

Category siRNA
Prices $500.00, $750.00
Sizes 150 µg, 300 µg
Species Reactivities Human
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