TDP1

Gene Symbol	TDP1
Entrez Gene	55775
Alt Symbol	-
Species	Human
Gene Type	protein-coding
Description	tyrosyl-DNA phosphodiesterase 1
Other Description	tyr-DNA phosphodiesterase 1
Swissprots	Q9NZM7 Q96BK7 Q9NZM8 Q2HXX4 Q9NUW8 Q86TV8
Accessions	ABC79301 CAC38574 EAW81414 EAW81415 EAW81416 Q9NUW8 AF182002 AAF65623 AF182003 AAF65624 AK001952 BAA91997 AK023514 BAG51203 AK093235 AK315549 BAG37927 AL832288 BC006083 AAH06083 BC015474 AAH15474 BC107877 AAI07878 BM661793 BU849335 BX161451 CAD61915 XM_005267847 XP_005267904 XM_005267848 XP_005267905 XM_006720197 XP_006720260 XM_006720198 XP_006720261 XM_006720199 XP_006720262 XM_006720200 XP_006720263 XM_011536941 XP_011535243 XM_011536942 XP_011535244 XM_011536943 XP_011535245 XM_011536944 XP_011535246 XR_943492 NM_001008744 NP_001008744 NM_018319 NP_060789
Function	DNA repair enzyme that can remove a variety of covalent adducts from DNA through hydrolysis of a 3'-phosphodiester bond, giving rise to DNA with a free 3' phosphate. Catalyzes the hydrolysis of dead-end complexes between DNA and the topoisomerase I active site tyrosine residue. Hydrolyzes 3'-phosphoglycolates on protruding 3' ends on DNA double-strand breaks due to DNA damage by radiation and free radicals. Acts on blunt-ended double-strand DNA breaks and on single-stranded DNA. Has low 3'exonuclease activity and can remove a single nucleoside from the 3'end of DNA and RNA molecules with 3'hydroxyl groups. Has no exonuclease activity towards DNA or RNA with a 3'phosphate. {ECO:0000269|PubMed:12023295, ECO:0000269|PubMed:15111055, ECO:0000269|PubMed:15811850, ECO:0000269|PubMed:16141202, ECO:0000269|PubMed:22822062}.
Subcellular Location	Nucleus {ECO:0000269|PubMed:15647511}. Cytoplasm {ECO:0000269|PubMed:15647511}.
Tissue Specificity	Ubiquitously expressed. Similar expression throughout the central nervous system (whole brain, amygdala, caudate nucleus, cerebellum, cerebral cortex, frontal lobe, hippocampus, medulla oblongata, occipital lobe, putamen, substantia nigra, temporal lobe, thalamus, nucleus accumbens and spinal cord) and increased expression in testis and thymus. {ECO:0000269|PubMed:12244316, ECO:0000269|PubMed:17948061}.

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human TDP1 full length protein - ab131921 from Abcam Category Protein Source Wheat germ Species Human

Human TDP1 full length protein - ab140052 from Abcam Category Protein Source E. coli Species Human

Human TDP1 peptide - ab13764 from Abcam Category Peptide

TDP1 Antibody Blocking Peptide - LS-E5211 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

TDP1 Antibody Blocking Peptide - LS-E20871 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

TDP1 Partial Recombinant Protein - H00055775-Q01 from Novus Biologicals Category Protein Prices $369.00 Sizes 10 µg Species Human

TDP1 Recombinant Protein - H00055775-P01 from Novus Biologicals Category Protein Prices $369.00 Sizes 10 µg Species Human

Recombinant Human TDP1 Protein - NBP2-22912 from Novus Biologicals Category Protein Prices $269.00 Sizes 100 µg Species Human

TDP1-Antibody-Center-Blocking-Peptide - BP17653c from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

Human TDP1 protein - orb169409 from Biorbyt Category Protein Prices $170.00, $289.00 Sizes 5 μg, 20 μg Source E. coli

Tdp1 Blocking Peptide - 33R-2766 from Fitzgerald Category Peptide Prices $130.00 Sizes 100 µg

TDP1 protein (His tag) - 80R-2654 from Fitzgerald Category Protein Prices $270.00 Sizes 100 µg Source E.coli

TDP1 (1-298, His-tag) - AR50774PU-N from Acris Antibodies Category Protein Prices $790.00 Sizes 500 µg Source E. coli Species Human

TDP1 (1-298, His-tag) - AR50774PU-S from Acris Antibodies Category Protein Prices $340.00 Sizes 100 µg Source E. coli Species Human

TDP1 - H00055775-P01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Source in vitro transl. Species Human

TDP1 - H00055775-P01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Source in vitro transl. Species Human

TDP1 - H00055775-Q01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Species Human

TDP1 - H00055775-Q01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Species Human

TDP1, 1-298aa Human, His tag, E.coli - 01-P1950 from ARP American Research Products Category Protein Prices $179.00, $369.00, $849.00 Sizes 20 µg, 100 µg, 500 µg Species Human

TDP1 fusion protein - ag0885 from Proteintech Group Category Protein Source E. coli-derived, PGEX-4T Species Human

TDP1 fusion protein - ag0964 from Proteintech Group Category Protein Source E. coli-derived, PGEX-4T Species Human

TDP1 Human - ENPS-692 from NeoScientific Category Protein Prices $65.00, $169.00, $3,510.00 Sizes 5 µg, 20 µg, 1 mg Source Escherichia Coli. Species Human

Recombinant Human TDP1, His-tagged - TDP1-7250H from Creative Biomart Category Protein Source E. coli Species Human

Recombinant Human Tyrosyl-DNA phosphodiesterase 1(TDP1) - CSB-YP023352HU CSB-EP023352HU CSB-BP023352HU CSB-MP023352HU from Cusabio Category Protein Source Yeast or E.coli or Baculovirus or Mammalian cell Species Human

TDP1, 1-298aa, Human, His tag, E.coli (Denatured) - ATGP1950 from ATGen Category Protein Prices $80.00, $240.00, $720.00 Sizes 20 µg, 100 µg, 500 µg Species Human

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