CLCN4

Gene Symbol CLCN4
Entrez Gene 1183
Alt Symbol CLC4, ClC-4, ClC-4A
Species Human
Gene Type protein-coding
Description chloride channel, voltage-sensitive 4
Other Description H(+)/Cl(-) exchange transporter 4|chloride channel 4|chloride channel protein 4|chloride transporter ClC-4
Swissprots Q9UBU1 B7Z5Z4 A1L3U1 P51793
Accessions AAC83175 EAW98777 EAW98778 P51793 AB019432 BAA77327 AF052117 AF170492 AAD50981 AK225287 AK289564 BAF82253 AK299611 BAH13080 BC036068 AAH36068 BC130278 AAI30279 BP310547 HQ258498 ADR83252 X77197 CAA54417 NM_001256944 NP_001243873 NM_001830 NP_001821
Function Proton-coupled chloride transporter. Functions as antiport system and exchanges chloride ions against protons. {ECO:0000269|PubMed:18063579}.
Subcellular Location Early endosome membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}. Late endosome membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}.
Tissue Specificity Abundant in skeletal muscle and also detectable in brain and heart.

CLC-4 (C-20) - sc-16435 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

Anti-CLCN4 antibody - ab105144 from Abcam

Host Rabbit
Clonality Polyclonal

Anti-CLCN4 antibody - ab75008 from Abcam

Prices $370.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
All lanes : Anti-CLCN4 antibody (ab75008) at 1/500 dilutionLane 1 : extracts from MCF-7 cellsLane 2 : extracts from MCF-7 cells with immunising peptide at 10 µgLysates/proteins at 30 µg per lane.

Anti-CLCN4 / CLC-4 Antibody (C-Terminus) - LS-C6129 from LifeSpan Bioscience

Prices $365.00
Sizes 50 µl
Host Rabbit
Clonality Polyclonal

Anti-CLCN4 / CLC-4 Antibody (C-Terminus) - LS-C6130 from LifeSpan Bioscience

Prices $385.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal

Anti-CLCN4 / CLC-4 Antibody (C-Terminus, AP) - LS-C276294 from LifeSpan Bioscience

Prices $515.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-CLCN4 / CLC-4 Antibody (C-Terminus, APC) - LS-C276296 from LifeSpan Bioscience

Prices $515.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-CLCN4 / CLC-4 Antibody (C-Terminus, Azide-free, HRP) - LS-C276298 from LifeSpan Bioscience

Prices $515.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-CLCN4 / CLC-4 Antibody (C-Terminus, PE) - LS-C276299 from LifeSpan Bioscience

Prices $515.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-CLCN4 / CLC-4 Antibody (C-Terminus, Biotin) - LS-C276297 from LifeSpan Bioscience

Prices $515.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-CLCN4 / CLC-4 Antibody (C-Terminus) - LS-C330379 from LifeSpan Bioscience

Prices $425.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-CLCN4 / CLC-4 Antibody (C-Terminus, FITC) - LS-C276300 from LifeSpan Bioscience

Prices $515.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-CLCN4 / CLC-4 Antibody (N-Terminus) - LS-C345322 from LifeSpan Bioscience

Prices $365.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Western blot of CLCN4 Antibody with human 721_B Whole Cell lysate.

Anti-CLCN4 / CLC-4 Antibody (aa221-270) - LS-C119846 from LifeSpan Bioscience

Prices $315.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Immunofluorescence of HUVEC cells, using CLCN4 Antibody. The picture on the right is treated with the synthesized peptide.

Anti-CLCN4 / CLC-4 Antibody (C-Terminus) - LS-C100107 from LifeSpan Bioscience

Prices $295.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
Retinae were collected from adult White Leghorn chicken and fixed in the eyecup for two hours in 4% Paraformaldehyde (in PBS). Retinae were then removed from the eyecups and incubated in 30% sucrose (in PBS) overnight. Retinal tissue was embedded and frozen in OCT compound and cut into ~15um sections on a cryotome. Sections were blocked in 5% normal goat serum (in 1%BSA/.1%saponin PBS) for one hour and then incubated at RT with 1:250 (1%BSA/.1% saponin PBS) ClC4 antibody for 1 hour. Sections were then washed in PBS (3X10minutes) and then treated with secondary antibody (1:500 Cy3) for one hour. After another PBS wash series, sections were coverslipped and antibody labeling was visualized at 20X with a Leica upright microscope using a TRITC filter set and Xenon LAMP illumination. (Crousillac et al, 2003)

Anti-CLCN4 / CLC-4 Antibody (Glu254) - LS-C177360 from LifeSpan Bioscience

Prices $345.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Western blot of CLC-4 (E254) pAb in extracts from MCF-7 cells.

CLCN4 Antibody - NBP2-30066 from Novus Biologicals

Prices $299.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
Western Blot: CLCN4 Antibody [NBP2-30066] - Chicken brain tissue incubated with CLC4 Antibody (C-term) (NBP2-30066). Data courtesy of Emily McMains, Louisiana State University.

CLCN4 Antibody - NBP1-84452 from Novus Biologicals

Prices $419.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Immunohistochemistry-Paraffin: CLCN4 Antibody [NBP1-84452] - Staining of human cerebellum shows moderate cytoplasmic positivity in Purkinje cells.

CLCN4 Antibody - NBP1-00755 from Novus Biologicals

Prices $349.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Western Blot: CLCN4 Antibody [NBP1-00755] - Western blot (WB) analysis of CLCN4 (E254) antibody in extracts from MCF-7 cells

Anti-CLC4 (C-term) antibody produced in rabbit - SAB1300783 from Sigma-Aldrich

Prices $291.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

ANTI-CLC4(C-TERMINAL) antibody produced in rabbit - SAB1305461 from Sigma-Aldrich

Prices $326.00
Sizes 40 tst
Host Rabbit
Clonality Polyclonal

Anti-CLCN4 antibody produced in rabbit - HPA031313 from Sigma-Aldrich

Prices $429.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
<B>Immunohistochemistry</B><BR/>Anti-CLCN4: <B>Cat. No. HPA031313</B>: Immunohistochemical staining of human pancreas shows strong cytoplasmic positivity in exocrine cells.

Anti-CLCN4 antibody produced in rabbit - SAB4500281 from Sigma-Aldrich

Prices $335.50
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
<B>Immunofluorescence</B><BR/>Anti-CLCN4: <B>Cat. No. SAB4500281</B>: Immunofluorescence of HuvEc cells using Anti-CLCN4 antibody. Cells on the left were treated with the Anti-CLCN4 antibody. Cells on the right (negative control) were treated with both Anti-CLCN4 antibody and the synthesized immunogen peptide.

CLCN4 Antibody - N-terminal region (ARP73792_P050) - ARP73792_P050 from Aviva Systems Biology

Prices $289.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

CLC4-Antibody-C-term - AP6329f from Abgent, a WuXi AppTec company

Prices $99.00, $295.00
Sizes 80 µl, 400 µl
Host Rabbit
Clonality Polyclonal
Western blot of chicken brain tissue incubated with CLC4 Antibody (C-term) (Cat.# AP6329f). Data courtesy of Emily McMains, Louisiana State University.
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