IFNAR1

Gene Symbol IFNAR1
Entrez Gene 3454
Alt Symbol AVP, IFN-alpha-REC, IFNAR, IFNBR, IFRC
Species Human
Gene Type protein-coding
Description interferon (alpha, beta and omega) receptor 1
Other Description CRF2-1|IFN-R-1|IFN-alpha/beta receptor 1|alpha-type antiviral protein|beta-type antiviral protein|cytokine receptor class-II member 1|cytokine receptor family 2 member 1|interferon alpha/beta receptor 1|interferon-alpha/beta receptor alpha chain|interferon-beta receptor 1|type I interferon receptor 1
Swissprots Q6PKD7 Q53GW9 B4DNT3 Q8WTZ2 B2R6L9 D3DSF0 P17181 Q53H11 Q7M4L2
Accessions AAT49100 CAA42992 EAX09837 EAX09838 EAX09839 P17181 AK123813 AK222770 BAD96490 AK222812 BAD96532 AK298051 BAG60345 AK312631 BAG35516 BC002590 AAH02590 BC014338 BC021825 AAH21825 BC035603 BC065751 BG116121 BG548299 BX537636 CA309858 DQ891323 ABM82249 DQ894507 ABM85433 J03171 AAA52730 R15745 XM_005260964 XP_005261021 XM_011529552 XP_011527854 NM_000629 NP_000620
Function Associates with IFNAR2 to form the type I interferon receptor. Receptor for interferons alpha and beta. Binding to type I IFNs triggers tyrosine phosphorylation of a number of proteins including JAKs, TYK2, STAT proteins and IFNR alpha- and beta- subunits themselves. Can also transduce IFNB signals without the help of IFNAR2, and not activating the Jak-STAT pathway.
Subcellular Location Isoform 1: Membrane; Single-pass type I membrane protein.
Tissue Specificity IFN receptors are present in all tissues and even on the surface of most IFN-resistant cells. Isoform 1, isoform 2 and isoform 3 are expressed in the IFN-alpha sensitive myeloma cell line U266B1. Isoform 2 and isoform 3 are expressed in the IFN-alpha resistant myeloma cell line U266R. Isoform 1 is not expressed in IFN-alpha resistant myeloma cell line U266R. {ECO:0000269|PubMed:8307198}.
Top Pathways Osteoclast differentiation, PI3K-Akt signaling pathway, Herpes simplex infection, Influenza A, Measles

IFN-α/βRα (H-11) - sc-7391 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
IFN-α/βRα (H-11): sc-7391. Western blot analysis of IFN-α/βRα expression in non-transfected: sc-117752 (A) and human IFN-α/βRα transfected: sc-113922 (B) 293T whole cell lysates.

IFN-α/βRα (R-100) - sc-845 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
IFN-α/βRα (R-100): sc-845. Western blot analysis of 20 ng IFN-α/βRα (D-457) fusion protein.

p-IFN-α/βRα (Ser 535/Ser 539) - sc-135700 from Santa Cruz Biotechnology

Prices $295.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
p-IFN-α/βRα (Ser 535/Ser 539): sc-135700. Western blot analysis of IFN-α/βRα phosphorylation in immuno-precipitates from HEK 293 cells transfected with mock vector (A,C,E) and IFN-α/βRα (B,D,F). Blots were probed with p-IFN-α/βRα (Ser 535/Ser 539): sc-135700 (A,B), p-IFN-a/bRa (Ser 535/Ser 539): sc-135700 preincubated with its cognate phosphorylated peptide (C,D) and p-IFN-α/βRα (Ser 535/Ser 539): sc-135700 preincubated with the corresponding unphosphorylated peptide (E,F).

Anti-IFNAR1 (phospho S535 + S539) antibody - ab30571 from Abcam

Prices $370.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Anti-IFNAR1 (phospho Y466) antibody - ab111921 from Abcam

Prices $370.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
ab111921 at 1/50 dilution staining IFNAR1 in paraffin-embedded Human Brain tissue by Immunohistochemistry. The image on the right is treated with the synthesized phosphopeptide.

Anti-IFNAR1 antibody - ab10739 from Abcam

Prices $372.00
Sizes 25 µg
Host Goat
Clonality Polyclonal

Anti-IFNAR1 antibody - ab62693 from Abcam

Prices $378.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
ab62693 at 1/50 dilution staining IFNAR1 in human brain by Immunohistochemistry, Paraffin-embedded tissue, in the absence or presence of the immunising peptide.

Anti-IFNAR1 antibody - ab91466 from Abcam

Prices $376.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
Anti-IFNAR1 antibody (ab91466) at 1/100 dilution + K562 cell line lysates at 35 µg

Anti-IFNAR1 antibody - ab112548 from Abcam

Prices $376.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
All lanes : Anti-IFNAR1 antibody (ab112548) at 1 µg/mlLane 1 : HeLa (Human epithelial carcinoma cell line) Whole Cell LysateLane 2 : INF-alpha Treated HeLa Cell LysateLane 3 : T24/83 (Human bladder carcinoma) Whole Cell LysateLysates/proteins at 10 µg per lane.SecondaryGoat Anti-Rabbit IgG H&L (HRP) (ab97051) at 1/10000 dilutiondeveloped using the ECL techniquePerformed under reducing conditions.

Anti-IFNAR1 antibody - ab97701 from Abcam

Prices $376.00
Sizes 50 µl
Host Rabbit
Clonality Polyclonal
Anti-IFNAR1 antibody (ab97701) at 1/1000 dilution + A431 whole cell lysate at 30 µg

Anti-IFNAR1 antibody - ab171996 from Abcam

Prices $376.00
Sizes 50 µg
Host Mouse
Clonality Polyclonal
All lanes : Anti-IFNAR1 antibody (ab171996) at 1 µg/mlLane 1 : IFNAR1 transfected 293T lysateLane 2 : Non-transfected 293T lysateLysates/proteins at 15 µl per lane.SecondaryGoat Anti-Mouse IgG (H&L)-HRP conjugated at 1/2500 dilutiondeveloped using the ECL technique

Anti-IFNAR1 antibody - ab175452 from Abcam

Prices $376.00
Sizes 200 µl
Host Goat
Clonality Polyclonal
Anti-IFNAR1 antibody (ab175452) at 0.3 µg/ml + K562 lysates at 35 µg

Anti-IFNAR1 antibody - ab55344 from Abcam

Prices $376.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Western blot against tagged recombinant protein immunogen using ab55344 IFNAR1 antibody at 1ug/ml.

Anti-IFNAR1 antibody - ab177250 from Abcam

Prices $370.00
Sizes 200 µl
Host Goat
Clonality Polyclonal

Anti-IFNAR1 antibody [EP899Y] - ab45172 from Abcam

Prices $392.00
Sizes 100 µl
Host Rabbit
Clonality Monoclonal
Clone EP899Y
Anti-IFNAR1 antibody [EP899Y] (ab45172) at 1/20000 dilution + K562 cell lysate at 10 µgSecondaryGoat anti rabbit HRP labelled. at 1/2000 dilution

Anti-Interferon Receptor alpha antibody - ab180812 from Abcam

Prices $376.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
All lanes : Anti-Interferon Receptor alpha antibody (ab180812) at 1/500 dilutionLane 1 : HeLa cell line extractsLane 2 : HepG2 cell line extractsLane 3 : SW480 cell line extracts

Anti-Interferon Receptor alpha antibody [EPR6244] - ab124764 from Abcam

Prices $390.00
Sizes 100 µl
Host Rabbit
Clonality Monoclonal
Clone EPR6244
All lanes : Anti-Interferon Receptor alpha antibody [EPR6244] (ab124764) at 1/1000 dilutionLane 1 : HeLa cell lysateLane 2 : HeLa cell lysate treated with IFN-alphaLane 3 : K562 cell lysateLane 4 : U937 cell lysateLysates/proteins at 10 µg per lane.SecondaryGoat anti-Rabbit HRP at 1/200 dilution

Anti-Interferon Receptor alpha antibody [MM0336-8H46] - ab90498 from Abcam

Prices $370.00
Sizes 50 µg
Host Mouse
Clonality Monoclonal
Clone MM0336-8H46

Anti-IFNAR1 / IFNAR Antibody (aa104-341) - LS-C294741 from LifeSpan Bioscience

Prices $395.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Western blot of recombinant IFNAR1 / IFNAR.

Anti-IFNAR1 / IFNAR Antibody (aa90-358) - LS-C294740 from LifeSpan Bioscience

Prices $415.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Western blot of recombinant IFNAR1 / IFNAR.

Anti-IFNAR1 / IFNAR Antibody (C-Terminus) - LS-C345300 from LifeSpan Bioscience

Prices $365.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Western blot of IFNAR1 Antibody with human OVCAR-3 Whole Cell lysate.

Anti-IFNAR1 / IFNAR Antibody (aa162-188) - LS-C165129 from LifeSpan Bioscience

Prices $295.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
Formalin-fixed and paraffin-embedded human hepatocarcinoma with IFNAR1 Antibody , which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated.

Anti-IFNAR1 / IFNAR Antibody (phospho-Ser535) - LS-C336003 from LifeSpan Bioscience

Prices $285.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Western blot analysis of extracts from 293 cells, using phospho-IFNAR1-S535/S539 antibody.

Anti-IFNAR1 / IFNAR Antibody - LS-C331651 from LifeSpan Bioscience

Prices $255.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Immunohistochemistry of paraffin-embedded human liver cancer using IFNAR1 antibody at dilution of 1:200 (x400 lens)

Anti-IFNAR1 / IFNAR Antibody (phospho-Ser535/Ser539) - LS-C70806 from LifeSpan Bioscience

Prices $485.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
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