IFNAR1

Gene Symbol	IFNAR1
Entrez Gene	3454
Alt Symbol	AVP, IFN-alpha-REC, IFNAR, IFNBR, IFRC
Species	Human
Gene Type	protein-coding
Description	interferon (alpha, beta and omega) receptor 1
Other Description	CRF2-1|IFN-R-1|IFN-alpha/beta receptor 1|alpha-type antiviral protein|beta-type antiviral protein|cytokine receptor class-II member 1|cytokine receptor family 2 member 1|interferon alpha/beta receptor 1|interferon-alpha/beta receptor alpha chain|interferon-beta receptor 1|type I interferon receptor 1
Swissprots	Q6PKD7 Q53GW9 B4DNT3 Q8WTZ2 B2R6L9 D3DSF0 P17181 Q53H11 Q7M4L2
Accessions	AAT49100 CAA42992 EAX09837 EAX09838 EAX09839 P17181 AK123813 AK222770 BAD96490 AK222812 BAD96532 AK298051 BAG60345 AK312631 BAG35516 BC002590 AAH02590 BC014338 BC021825 AAH21825 BC035603 BC065751 BG116121 BG548299 BX537636 CA309858 DQ891323 ABM82249 DQ894507 ABM85433 J03171 AAA52730 R15745 XM_005260964 XP_005261021 XM_011529552 XP_011527854 NM_000629 NP_000620
Function	Associates with IFNAR2 to form the type I interferon receptor. Receptor for interferons alpha and beta. Binding to type I IFNs triggers tyrosine phosphorylation of a number of proteins including JAKs, TYK2, STAT proteins and IFNR alpha- and beta- subunits themselves. Can also transduce IFNB signals without the help of IFNAR2, and not activating the Jak-STAT pathway.
Subcellular Location	Isoform 1: Membrane; Single-pass type I membrane protein.
Tissue Specificity	IFN receptors are present in all tissues and even on the surface of most IFN-resistant cells. Isoform 1, isoform 2 and isoform 3 are expressed in the IFN-alpha sensitive myeloma cell line U266B1. Isoform 2 and isoform 3 are expressed in the IFN-alpha resistant myeloma cell line U266R. Isoform 1 is not expressed in IFN-alpha resistant myeloma cell line U266R. {ECO:0000269|PubMed:8307198}.
Top Pathways	Osteoclast differentiation, PI3K-Akt signaling pathway, Herpes simplex infection, Influenza A, Measles

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human IFNAR1 protein fragment - ab114292 from Abcam Category Protein Source Wheat germ Species Human

Human IFNAR1 protein fragment - ab151659 from Abcam Category Protein Source HEK 293 cells Species Human

IFNAR1 / IFNAR Antibody Blocking Peptide - LS-E28081 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

IFNAR1 / IFNAR Antibody Blocking Peptide - LS-E9635 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

IFN-alpha/beta R1 Recombinant Protein - H00003454-P01 from Novus Biologicals Category Protein Prices $349.00 Sizes 10 µg Species Human

IFNAR1-Antibody-Center-Blocking-Peptide - BP8550c from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

IFNAR2 blocking peptide - GTX88651-PEP from GeneTex Category Peptide Prices $239.00 Sizes 100 μg Species Human

Recombinant Human IFN-alpha/beta R1, CF - 245-AB-050 from R&D Systems Category Protein Source Mouse myeloma cell line, NS0-derived, Gly26-Lys436

Cynomolgus IFNAR1 protein - orb139062 from Biorbyt Category Protein Prices $400.00, $612.00 Sizes 50 μg, 100 μg Source Human Cells

Human IFNAR1 protein - orb244295 from Biorbyt Category Protein Prices $340.00, $629.00, $1,003.00, $1,556.00 Sizes 50 μg, 200 μg, 500 μg, 1 mg Species Human

Human IFNAR1 protein (His Tag) - orb139060 from Biorbyt Category Protein Prices $434.00, $646.00 Sizes 50 μg, 100 μg Source Human Cells Species Human

Cynomolgus IFNAR1 protein - orb139063 from Biorbyt Category Protein Prices $400.00, $612.00 Sizes 50 μg, 100 μg Source Human Cells

Cynomolgus IFNAR1 protein (His Tag) - orb139061 from Biorbyt Category Protein Prices $400.00, $612.00 Sizes 50 μg, 100 μg Source Human Cells

Human IFNalpha /beta R1 protein - orb49455 from Biorbyt Category Protein Prices $272.00, $366.00, $1,904.00, $2,695.00 Sizes 10 μg, 50 μg, 500 μg, 1 mg Species Human

Human IFNAR1 protein - orb139059 from Biorbyt Category Protein Prices $434.00, $646.00 Sizes 50 μg, 100 μg Source Human Cells Species Human

Human IFNa/bR1 Protein - abx067339 from Abbexa Category Protein Source E.coli Species Human

IFNAR1 (phospho-Tyr466) Blocking Peptide - abx062139 from Abbexa Category Peptide Species Human

IFNAR1 Peptide - AC21-2961-P from Abcore Category Peptide Prices $160.00 Sizes 100 µg

IFNAR1 Peptide - AC21-2962-P from Abcore Category Peptide Prices $160.00 Sizes 100 µg

IFNAR1 - H00003454-Q01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Source in vitro transl. Species Human

IFNAR1 - H00003454-Q01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Source in vitro transl. Species Human

Interferon Alpha/Beta Receptor 1 (IFNa/bR1), Human - 20-7704 from ARP American Research Products Category Protein Prices $609.00 Sizes 50 µg Source E.coli Species Human

Interferon-alpha, beta Receptor 1, Human, Recombinant - 19-C358 from ARP American Research Products Category Protein Prices $109.00 Sizes 10 µg Source HEK293 Species Human

IFNAR 1 Recombinant Protein - 96-405 from ProSci Category Protein Prices $425.00 Sizes 100 µg Source HEK293 cells Species Human

IFNAR1 fusion protein - ag3739 from Proteintech Group Category Protein Source E. coli-derived, PGEX-4T Species Human

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