| Gene Symbol |
IFNAR1
|
| Entrez Gene |
3454
|
| Alt Symbol |
AVP, IFN-alpha-REC, IFNAR, IFNBR, IFRC
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
interferon (alpha, beta and omega) receptor 1
|
| Other Description |
CRF2-1|IFN-R-1|IFN-alpha/beta receptor 1|alpha-type antiviral protein|beta-type antiviral protein|cytokine receptor class-II member 1|cytokine receptor family 2 member 1|interferon alpha/beta receptor 1|interferon-alpha/beta receptor alpha chain|interferon-beta receptor 1|type I interferon receptor 1
|
| Swissprots |
Q6PKD7 Q53GW9 B4DNT3 Q8WTZ2 B2R6L9 D3DSF0 P17181 Q53H11 Q7M4L2
|
| Accessions |
AAT49100 CAA42992 EAX09837 EAX09838 EAX09839 P17181 AK123813 AK222770 BAD96490 AK222812 BAD96532 AK298051 BAG60345 AK312631 BAG35516 BC002590 AAH02590 BC014338 BC021825 AAH21825 BC035603 BC065751 BG116121 BG548299 BX537636 CA309858 DQ891323 ABM82249 DQ894507 ABM85433 J03171 AAA52730 R15745 XM_005260964 XP_005261021 XM_011529552 XP_011527854 NM_000629 NP_000620
|
| Function |
Associates with IFNAR2 to form the type I interferon receptor. Receptor for interferons alpha and beta. Binding to type I IFNs triggers tyrosine phosphorylation of a number of proteins including JAKs, TYK2, STAT proteins and IFNR alpha- and beta- subunits themselves. Can also transduce IFNB signals without the help of IFNAR2, and not activating the Jak-STAT pathway.
|
| Subcellular Location |
Isoform 1: Membrane; Single-pass type I membrane protein.
|
| Tissue Specificity |
IFN receptors are present in all tissues and even on the surface of most IFN-resistant cells. Isoform 1, isoform 2 and isoform 3 are expressed in the IFN-alpha sensitive myeloma cell line U266B1. Isoform 2 and isoform 3 are expressed in the IFN-alpha resistant myeloma cell line U266R. Isoform 1 is not expressed in IFN-alpha resistant myeloma cell line U266R. {ECO:0000269|PubMed:8307198}.
|
| Top Pathways |
Osteoclast differentiation, PI3K-Akt signaling pathway, Herpes simplex infection, Influenza A, Measles
|