| Gene Symbol |
UXT
|
| Entrez Gene |
8409
|
| Alt Symbol |
ART-27, STAP1
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
ubiquitously-expressed, prefoldin-like chaperone
|
| Other Description |
SKP2-associated alpha PFD 1|androgen receptor trapped clone 27 protein|protein UXT|ubiquitously expressed transcript protein
|
| Swissprots |
Q9Y6E5 Q5JZG3 Q9UBK9 B2R561
|
| Accessions |
CAH05296 CAH05297 EAW59324 EAW59325 EAW59326 Q9UBK9 AF083241 AAD39839 AF083242 AAD39840 AF092737 AAD28698 AK223320 AK312072 BAG35008 BC000720 AAH00720 BC008890 AAH08890 BM471483 BQ681820 DA372561 EL949569 NM_004182 NP_004173 NM_153477 NP_705582 NR_045559 NR_045560
|
| Function |
Involved in gene transcription regulation. Acts in concert with the corepressor URI1 to regulate androgen receptor transcription (AR). AR N-terminus-associated coactivator which may play a role in facilitating receptor-induced transcriptional activation (PubMed:11854421). Potential component of mitochondrial-associated LRPPRC, a multidomain organizer that potentially integrates mitochondria and the microtubular cytoskeleton with chromosome remodeling (PubMed:11827465). Increasing concentrations of UXT contributes to progressive aggregation of mitochondria and cell death potentially through its association with LRPPRC (PubMed:17554592). May be a nuclear chaperone that promotes formation of the NF-kappa-B enhanceosome and which is essential for its nuclear function (PubMed:17620405). Suppresses cell transformation and it might mediate this function by interaction and inhibition of the biological activity of cell proliferation and survival stimulatory factors like MECOM (PubMed:17635584).
|
| Subcellular Location |
Cytoplasm. Cytoplasm, cytoskeleton. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Nucleus.
|
| Tissue Specificity |
Ubiquitous. Expressed in prostate epithelial cells. Overexpressed in a number of tumor tissues (PubMed:16221885). Highest levels in the heart, skeletal muscle, pancreas, kidney, liver, adrenal gland, peripheral blood leukocytes, lymph node, prostate, and thyroid and the lowest levels in bladder and uterus. {ECO:0000269|PubMed:11854421, ECO:0000269|PubMed:16221885, ECO:0000269|PubMed:17635584, ECO:0000269|PubMed:21730289}.
|