UXT

Gene Symbol	UXT
Entrez Gene	8409
Alt Symbol	ART-27, STAP1
Species	Human
Gene Type	protein-coding
Description	ubiquitously-expressed, prefoldin-like chaperone
Other Description	SKP2-associated alpha PFD 1|androgen receptor trapped clone 27 protein|protein UXT|ubiquitously expressed transcript protein
Swissprots	Q9Y6E5 Q5JZG3 Q9UBK9 B2R561
Accessions	CAH05296 CAH05297 EAW59324 EAW59325 EAW59326 Q9UBK9 AF083241 AAD39839 AF083242 AAD39840 AF092737 AAD28698 AK223320 AK312072 BAG35008 BC000720 AAH00720 BC008890 AAH08890 BM471483 BQ681820 DA372561 EL949569 NM_004182 NP_004173 NM_153477 NP_705582 NR_045559 NR_045560
Function	Involved in gene transcription regulation. Acts in concert with the corepressor URI1 to regulate androgen receptor transcription (AR). AR N-terminus-associated coactivator which may play a role in facilitating receptor-induced transcriptional activation (PubMed:11854421). Potential component of mitochondrial-associated LRPPRC, a multidomain organizer that potentially integrates mitochondria and the microtubular cytoskeleton with chromosome remodeling (PubMed:11827465). Increasing concentrations of UXT contributes to progressive aggregation of mitochondria and cell death potentially through its association with LRPPRC (PubMed:17554592). May be a nuclear chaperone that promotes formation of the NF-kappa-B enhanceosome and which is essential for its nuclear function (PubMed:17620405). Suppresses cell transformation and it might mediate this function by interaction and inhibition of the biological activity of cell proliferation and survival stimulatory factors like MECOM (PubMed:17635584).
Subcellular Location	Cytoplasm. Cytoplasm, cytoskeleton. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Nucleus.
Tissue Specificity	Ubiquitous. Expressed in prostate epithelial cells. Overexpressed in a number of tumor tissues (PubMed:16221885). Highest levels in the heart, skeletal muscle, pancreas, kidney, liver, adrenal gland, peripheral blood leukocytes, lymph node, prostate, and thyroid and the lowest levels in bladder and uterus. {ECO:0000269|PubMed:11854421, ECO:0000269|PubMed:16221885, ECO:0000269|PubMed:17635584, ECO:0000269|PubMed:21730289}.

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human UXT full length protein - ab139207 from Abcam Category Protein Source E. coli Species Human

STAP1 / BRDG1 Antibody Blocking Peptide - LS-E3562 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

STAP1 / BRDG1 Antibody Blocking Peptide - LS-E24196 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

UXT Antibody Blocking Peptide - LS-E18434 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

UXT Antibody Blocking Peptide - LS-E26554 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

UXT Antibody Blocking Peptide - LS-E17351 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

UXT Recombinant Protein - H00008409-P01 from Novus Biologicals Category Protein Prices $369.00 Sizes 10 µg Species Human

UXT Partial Recombinant Protein - H00008409-Q01 from Novus Biologicals Category Protein Prices $369.00 Sizes 10 µg Species Human

BRDG1/STAP-1 Recombinant Protein - H00026228-P01 from Novus Biologicals Category Protein Prices $369.00 Sizes 10 µg Species Human

BRDG1/STAP-1 Partial Recombinant Protein - H00026228-Q01 from Novus Biologicals Category Protein Prices $369.00 Sizes 10 µg Species Human

UXT Protein - NBP2-22926 from Novus Biologicals Category Protein Species Human

BRDG1/STAP-1 Protein - NBP1-98975 from Novus Biologicals Category Protein Prices $309.00 Sizes 100 µg Species Human

BRDG-1-Antibody-N-term-F56-Blocking-peptide - BP1475a from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

UXT blocking peptide - GTX88619-PEP from GeneTex Category Peptide Prices $239.00 Sizes 100 μg Species Human

Human UXT protein - orb169534 from Biorbyt Category Protein Prices $170.00, $289.00 Sizes 5 μg, 20 μg Species Human

UXT Blocking Peptide - 33R-5784 from Fitzgerald Category Peptide Prices $130.00 Sizes 100 µg

UXT Blocking Peptide - 33R-5785 from Fitzgerald Category Peptide Prices $130.00 Sizes 100 µg

UXT protein (His tag) - 30R-2911 from Fitzgerald Category Protein Prices $270.00 Sizes 100 µg Source E.coli

UXT Peptide - AC21-1392-P from Abcore Category Peptide Prices $160.00 Sizes 100 µg

UXT / HSPC024 (1-157, His-tag) - AR50671PU-N from Acris Antibodies Category Protein Prices $790.00 Sizes 500 µg Source E. coli Species Human

UXT / HSPC024 (1-157, His-tag) - AR50671PU-S from Acris Antibodies Category Protein Prices $340.00 Sizes 100 µg Source E. coli Species Human

UXT / HSPC024 - H00008409-P01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Species Human

UXT / HSPC024 - H00008409-P01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Species Human

UXT / HSPC024 - H00008409-Q01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Source in vitro transl. Species Human

UXT / HSPC024 - H00008409-Q01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Source in vitro transl. Species Human

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