UXT

Gene Symbol UXT
Entrez Gene 8409
Alt Symbol ART-27, STAP1
Species Human
Gene Type protein-coding
Description ubiquitously-expressed, prefoldin-like chaperone
Other Description SKP2-associated alpha PFD 1|androgen receptor trapped clone 27 protein|protein UXT|ubiquitously expressed transcript protein
Swissprots Q9Y6E5 Q5JZG3 Q9UBK9 B2R561
Accessions CAH05296 CAH05297 EAW59324 EAW59325 EAW59326 Q9UBK9 AF083241 AAD39839 AF083242 AAD39840 AF092737 AAD28698 AK223320 AK312072 BAG35008 BC000720 AAH00720 BC008890 AAH08890 BM471483 BQ681820 DA372561 EL949569 NM_004182 NP_004173 NM_153477 NP_705582 NR_045559 NR_045560
Function Involved in gene transcription regulation. Acts in concert with the corepressor URI1 to regulate androgen receptor transcription (AR). AR N-terminus-associated coactivator which may play a role in facilitating receptor-induced transcriptional activation (PubMed:11854421). Potential component of mitochondrial-associated LRPPRC, a multidomain organizer that potentially integrates mitochondria and the microtubular cytoskeleton with chromosome remodeling (PubMed:11827465). Increasing concentrations of UXT contributes to progressive aggregation of mitochondria and cell death potentially through its association with LRPPRC (PubMed:17554592). May be a nuclear chaperone that promotes formation of the NF-kappa-B enhanceosome and which is essential for its nuclear function (PubMed:17620405). Suppresses cell transformation and it might mediate this function by interaction and inhibition of the biological activity of cell proliferation and survival stimulatory factors like MECOM (PubMed:17635584).
Subcellular Location Cytoplasm. Cytoplasm, cytoskeleton. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Nucleus.
Tissue Specificity Ubiquitous. Expressed in prostate epithelial cells. Overexpressed in a number of tumor tissues (PubMed:16221885). Highest levels in the heart, skeletal muscle, pancreas, kidney, liver, adrenal gland, peripheral blood leukocytes, lymph node, prostate, and thyroid and the lowest levels in bladder and uterus. {ECO:0000269|PubMed:11854421, ECO:0000269|PubMed:16221885, ECO:0000269|PubMed:17635584, ECO:0000269|PubMed:21730289}.

UXT CRISPR/Cas9 KO Plasmid (h) - sc-403823 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

UXT HDR Plasmid (h) - sc-403823-HDR from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

UXT Double Nickase Plasmid (h) - sc-403823-NIC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

UXT Double Nickase Plasmid (h2) - sc-403823-NIC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

UXT CRISPR Activation Plasmid (h) - sc-403823-ACT from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

UXT CRISPR Activation Plasmid (h2) - sc-403823-ACT-2 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

UXT Lentiviral Activation Particles (h) - sc-403823-LAC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

UXT Lentiviral Activation Particles (h2) - sc-403823-LAC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

UXT siRNA (h) - sc-90973 from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

UXT shRNA Plasmid (h) - sc-90973-SH from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

UXT shRNA (h) Lentiviral Particles - sc-90973-V from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

BRDG1/STAP-1 RNAi - H00026228-R01 from Novus Biologicals

Category siRNA
Prices $399.00
Sizes 20 nmol
Species Reactivities Human

MISSION® esiRNA - EHU085831 from Sigma-Aldrich

Category siRNA
Prices $140.00, $250.00
Sizes 20 µg, 50 µg

CompoZr® Knockout ZFN Kit - CKOZFN22628 from Sigma-Aldrich

Category ZFN Kit
Prices $4,999.00
Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND22628 from Sigma-Aldrich

Category ZFN Kit
Prices $3,999.00
Sizes 1 kt

UXT siRNA (Human) - CRH5512 from Cohesion Biosciences

Category siRNA
Prices $340.00, $510.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

UXT - MBS8215736 from MyBioSource

Prices $365.00, $515.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

shRNA set against Human UXT (NM_004182.3) - SHH442072 from Creative biogene

Category siRNA
Species Reactivities Human

Human UXT siRNA - orb266014 from Biorbyt

Category siRNA
Prices $485.00, $629.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

UXT shRNA Plasmid (Human) - CHH5512 from Cohesion Biosciences

Category siRNA
Prices $500.00, $750.00
Sizes 150 µg, 300 µg
Species Reactivities Human

UXT miRNA 3'UTR clone - MiUTR3H-02658 from Creative biogene

Species Reactivities Human
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