Gene Symbol | PKDCC |
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Entrez Gene | 91461 |
Alt Symbol | SGK493, Vlk |
Species | Human |
Gene Type | protein-coding |
Description | protein kinase domain containing, cytoplasmic |
Other Description | extracellular tyrosine-protein kinase PKDCC|protein kinase domain containing, cytoplasmic homolog|protein kinase domain-containing protein, cytoplasmic|protein kinase-like protein SgK493|sugen kinase 493|vertebrate lonesome kinase |
Swissprots | Q96I09 D6W5A0 Q504Y2 |
Accessions | EAX00325 EAX00326 Q504Y2 AK311155 BC007901 AAH07901 BC062988 AAH62988 BC094697 AAH94697 BC110513 AAI10514 BC110514 AAI10515 BM738316 BQ013425 CF131963 DB231841 DB457034 NM_138370 NP_612379 |
Function | Secreted tyrosine-protein kinase that mediates phosphorylation of extracellular proteins and endogenous proteins in the secretory pathway, which is essential for patterning at organogenesis stages. Mediates phosphorylation of MMP1, MMP13, MMP14, MMP19 and ERP29 (PubMed:25171405). Probably plays a role in platelets: rapidly and quantitatively secreted from platelets in response to stimulation of platelet degranulation (PubMed:25171405). May also have serine/threonine protein kinase activity. Required for longitudinal bone growth through regulation of chondrocyte differentiation. May be indirectly involved in protein transport from the Golgi apparatus to the plasma membrane (By similarity). {ECO:0000250|UniProtKB:Q5RJI4, ECO:0000269|PubMed:25171405}. |
Subcellular Location | Secreted {ECO:0000269|PubMed:25171405}. Golgi apparatus {ECO:0000250|UniProtKB:Q5RJI4}. |
Tissue Specificity | Highly expressed in platelets. {ECO:0000269|PubMed:25171405}. |
PKDCC (P-15) - sc-169299 from Santa Cruz Biotechnology
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PKDCC (N-14) - sc-169298 from Santa Cruz Biotechnology
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PKDCC (T-15) - sc-169300 from Santa Cruz Biotechnology
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Anti-Protein kinase-like protein SgK493 antibody - ab106413 from Abcam
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Anti-Protein kinase-like protein SgK493 antibody - ab67825 from Abcam
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Anti-PKDCC / SGK493 Antibody (Internal) IHC-plus⢠- LS-B5068 from LifeSpan Bioscience
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Protein kinase-like protein SgK493 Antibody - NBP2-19959 from Novus Biologicals
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Protein kinase-like protein SgK493 Antibody - NBP1-80756 from Novus Biologicals
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Protein kinase-like protein SgK493 Antibody - NBP2-19960 from Novus Biologicals
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Protein kinase-like protein SgK493 Antibody - H00091461-B01 from Novus Biologicals
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Protein kinase-like protein SgK493 Antibody - H00091461-B01P from Novus Biologicals
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Anti-LOC91461 antibody produced in mouse - SAB1408179 from Sigma-Aldrich
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Anti-PKDCC antibody produced in rabbit - HPA026442 from Sigma-Aldrich
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Anti-PKDCC antibody produced in rabbit - HPA026526 from Sigma-Aldrich
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Anti-PKDCC antibody produced in rabbit - HPA026427 from Sigma-Aldrich
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VLK antibody - orb75339 from Biorbyt
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PKDCC (Center) antibody - AP26333PU-N from Acris Antibodies
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PKDCC antibody - H00091461-B01 from Acris Antibodies
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PKDCC antibody - H00091461-B01P from Acris Antibodies
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Rabbit Anti-Human PKDCC (Internal) - 119-14924 from RayBiotech
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VLK Antibody - 5561 from ProSci
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Anti-PKDCC (aa 162-383) polyclonal antibody - DPABH-05248 from Creative Diagnostics
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Anti-PKDCC monoclonal antibody - DCABH-201468 from Creative Diagnostics
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VLK Polyclonal Antibody - PA5-30893 from Thermo Fisher Scientific
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VLK Polyclonal Antibody - PA5-31510 from Thermo Fisher Scientific
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