| Gene Symbol |
PKDCC
|
| Entrez Gene |
91461
|
| Alt Symbol |
SGK493, Vlk
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
protein kinase domain containing, cytoplasmic
|
| Other Description |
extracellular tyrosine-protein kinase PKDCC|protein kinase domain containing, cytoplasmic homolog|protein kinase domain-containing protein, cytoplasmic|protein kinase-like protein SgK493|sugen kinase 493|vertebrate lonesome kinase
|
| Swissprots |
Q96I09 D6W5A0 Q504Y2
|
| Accessions |
EAX00325 EAX00326 Q504Y2 AK311155 BC007901 AAH07901 BC062988 AAH62988 BC094697 AAH94697 BC110513 AAI10514 BC110514 AAI10515 BM738316 BQ013425 CF131963 DB231841 DB457034 NM_138370 NP_612379
|
| Function |
Secreted tyrosine-protein kinase that mediates phosphorylation of extracellular proteins and endogenous proteins in the secretory pathway, which is essential for patterning at organogenesis stages. Mediates phosphorylation of MMP1, MMP13, MMP14, MMP19 and ERP29 (PubMed:25171405). Probably plays a role in platelets: rapidly and quantitatively secreted from platelets in response to stimulation of platelet degranulation (PubMed:25171405). May also have serine/threonine protein kinase activity. Required for longitudinal bone growth through regulation of chondrocyte differentiation. May be indirectly involved in protein transport from the Golgi apparatus to the plasma membrane (By similarity). {ECO:0000250|UniProtKB:Q5RJI4, ECO:0000269|PubMed:25171405}.
|
| Subcellular Location |
Secreted {ECO:0000269|PubMed:25171405}. Golgi apparatus {ECO:0000250|UniProtKB:Q5RJI4}.
|
| Tissue Specificity |
Highly expressed in platelets. {ECO:0000269|PubMed:25171405}.
|