INSC

Gene Symbol INSC
Entrez Gene 387755
Alt Symbol -
Species Human
Gene Type protein-coding
Description inscuteable homolog (Drosophila)
Other Description inscuteable spindle orientation adaptor protein|protein inscuteable homolog
Swissprots Q4AC97 A0PJX5 Q4AC96 Q3C1V6 Q4AC98 Q1MX18 Q4AC95 Q1MX19
Accessions Q1MX18 AB231744 BAE46891 AB231745 BAE17133 AB231746 BAE17134 AB231747 BAE17135 AB231748 BAE17136 AB231749 BAE46892 AB236158 BAE93463 AB236159 BAE93464 BC117561 BC127700 AAI27701 BC156332 AAI56333 BC157083 AAI57084 BU147420 DY654442 XM_006718227 XP_006718290 XM_011520082 XP_011518384 XM_011520083 XP_011518385 XM_011520084 XP_011518386 XM_011520085 XP_011518387 XM_011520086 XP_011518388 XM_011520087 XP_011518389 XM_011520088 XP_011518390 XR_930868 NM_001031853 NP_001027024 NM_001042536 NP_001036001 NM_001278313 NP_001265242 NM_001278314 NP_001265243 NM_001278315 NP_001265244 NM_001278316 NP_001265245
Function May function as an adapter linking the Par3 complex to the GPSM1/GPSM2 complex. Involved in spindle orientation during mitosis it may regulate cell proliferation and differentiation in the developing nervous system. May play a role in the asymmetric division of fibroblasts and participate in the process of stratification of the squamous epithelium. {ECO:0000269|PubMed:16458856}.
Subcellular Location Cytoplasm. Note=Localizes to the apical cortex of mitotic epidermal cells and to the apical side of neuronal progenitor cells. {ECO:0000250}.
Tissue Specificity Isoform 1 is expressed in various tissues with stronger expression in liver, kidney and small intestine. Isoform 2 is abundantly expressed in small intestine and to a lower extent in lung and pancreas. {ECO:0000269|PubMed:12469229, ECO:0000269|PubMed:16458856}.

INSC (G-6) - sc-514398 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
INSC (G-6): sc-514398. Western blot analysis of INSC expression in c4 (A) and Caki-1 (B) whole cell lysates.

INSC (C-15) - sc-243091 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
INSC (C-15): sc-243091. Western blot analysis of INSC expression in WI-38 (A) and MIA PaCa-2 (B) whole cell lysates.

INSC (Y-17) - sc-243089 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
INSC (Y-17): sc-243089. Western blot analysis of INSC expression in mouse liver tissue extract.

Anti-INSC antibody - ab102953 from Abcam

Prices $370.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
ICC/IF image of ab102953 stained HeLa cells. The cells were 4% formaldehyde fixed (10 min) and then incubated in 1%BSA / 10% normal goat serum / 0.3M glycine in 0.1% PBS-Tween for 1h to permeabilise the cells and block non-specific protein-protein interactions. The cells were then incubated with the antibody ab102953 at 5µg/ml overnight at +4°C. The secondary antibody (green) was DyLight® 488 goat anti- rabbit (ab96899) IgG (H+L) used at a 1/250 dilution for 1h. Alexa Fluor® 594 WGA was used to label plasma membranes (red) at a 1/200 dilution for 1h. DAPI was used to stain the cell nuclei (blue) at a concentration of 1.43µM.

Anti-INSC antibody - ab107096 from Abcam

Prices $359.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Anti-INSC antibody (ab107096) at 1/100 dilution + Mouse liver tissue lysate at 35 µg

Anti-INSC antibody [EPR13470] - ab181210 from Abcam

Prices $357.00
Sizes 100 µl
Host Rabbit
Clonality Monoclonal
Clone EPR13470
All lanes : Anti-INSC antibody [EPR13470] (ab181210) at 1/1000 dilutionLane 1 : Human fetal liver lysateLane 2 : 293 lysateLysates/proteins at 10 µg per lane.SecondaryGoat Anti-Rabbit IgG H&L (HRP) (ab136636) at 1/500 dilution

Anti-INSC Antibody (aa409-437, AP) - LS-C260265 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-INSC Antibody (aa409-437, APC) - LS-C260266 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-INSC Antibody - LS-C190095 from LifeSpan Bioscience

Prices $485.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-INSC Antibody (aa409-437, Biotin) - LS-C260267 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-INSC Antibody (aa409-437, FITC) - LS-C260268 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-INSC Antibody (aa410-437, AP) - LS-C260270 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-INSC Antibody (aa409-437, Azide-free, HRP) - LS-C260269 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-INSC Antibody (aa409-437, PE) - LS-C260271 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-INSC Antibody (aa410-437, FITC) - LS-C260274 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-INSC Antibody (aa410-437, Biotin) - LS-C260273 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-INSC Antibody (aa410-437, APC) - LS-C260272 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-INSC Antibody (aa410-437, PE) - LS-C260276 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-INSC Antibody (aa416-445) - LS-C322250 from LifeSpan Bioscience

Prices $345.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-INSC Antibody (aa416-446) - LS-C322251 from LifeSpan Bioscience

Prices $345.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-INSC Antibody (aa410-437, Azide-free, HRP) - LS-C260275 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-INSC Antibody (aa409-437) - LS-C165252 from LifeSpan Bioscience

Prices $295.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
INSC antibody immunohistochemistry of formalin-fixed and paraffin-embedded human kidney tissue followed by peroxidase-conjugated secondary antibody and DAB staining.

Anti-INSC Antibody (aa410-437) - LS-C165253 from LifeSpan Bioscience

Prices $295.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
INSC Antibody IHC of formalin-fixed and paraffin-embedded hepatocarcinoma followed by peroxidase-conjugated secondary antibody and DAB staining.

INSC Antibody - NBP1-90980 from Novus Biologicals

Prices $419.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Immunohistochemistry: INSC Antibody [NBP1-90980] - Staining of human colon shows strong cytoplasmic and membranous positivity in glandular cells.

INSC Polyclonal Antibody - bs-7838R from Bioss

Prices $269.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
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