| Gene Symbol | INSC |
|---|---|
| Entrez Gene | 387755 |
| Alt Symbol | - |
| Species | Human |
| Gene Type | protein-coding |
| Description | inscuteable homolog (Drosophila) |
| Other Description | inscuteable spindle orientation adaptor protein|protein inscuteable homolog |
| Swissprots | Q4AC97 A0PJX5 Q4AC96 Q3C1V6 Q4AC98 Q1MX18 Q4AC95 Q1MX19 |
| Accessions | Q1MX18 AB231744 BAE46891 AB231745 BAE17133 AB231746 BAE17134 AB231747 BAE17135 AB231748 BAE17136 AB231749 BAE46892 AB236158 BAE93463 AB236159 BAE93464 BC117561 BC127700 AAI27701 BC156332 AAI56333 BC157083 AAI57084 BU147420 DY654442 XM_006718227 XP_006718290 XM_011520082 XP_011518384 XM_011520083 XP_011518385 XM_011520084 XP_011518386 XM_011520085 XP_011518387 XM_011520086 XP_011518388 XM_011520087 XP_011518389 XM_011520088 XP_011518390 XR_930868 NM_001031853 NP_001027024 NM_001042536 NP_001036001 NM_001278313 NP_001265242 NM_001278314 NP_001265243 NM_001278315 NP_001265244 NM_001278316 NP_001265245 |
| Function | May function as an adapter linking the Par3 complex to the GPSM1/GPSM2 complex. Involved in spindle orientation during mitosis it may regulate cell proliferation and differentiation in the developing nervous system. May play a role in the asymmetric division of fibroblasts and participate in the process of stratification of the squamous epithelium. {ECO:0000269|PubMed:16458856}. |
| Subcellular Location | Cytoplasm. Note=Localizes to the apical cortex of mitotic epidermal cells and to the apical side of neuronal progenitor cells. {ECO:0000250}. |
| Tissue Specificity | Isoform 1 is expressed in various tissues with stronger expression in liver, kidney and small intestine. Isoform 2 is abundantly expressed in small intestine and to a lower extent in lung and pancreas. {ECO:0000269|PubMed:12469229, ECO:0000269|PubMed:16458856}. |
INSC CRISPR/Cas9 KO Plasmid (h) - sc-408365 from Santa Cruz Biotechnology
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INSC HDR Plasmid (h) - sc-408365-HDR from Santa Cruz Biotechnology
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INSC Double Nickase Plasmid (h) - sc-408365-NIC from Santa Cruz Biotechnology
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INSC Double Nickase Plasmid (h2) - sc-408365-NIC-2 from Santa Cruz Biotechnology
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INSC CRISPR Activation Plasmid (h) - sc-408365-ACT from Santa Cruz Biotechnology
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INSC CRISPR Activation Plasmid (h2) - sc-408365-ACT-2 from Santa Cruz Biotechnology
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INSC Lentiviral Activation Particles (h) - sc-408365-LAC from Santa Cruz Biotechnology
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INSC Lentiviral Activation Particles (h2) - sc-408365-LAC-2 from Santa Cruz Biotechnology
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INSC siRNA (h) - sc-96461 from Santa Cruz Biotechnology
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INSC shRNA Plasmid (h) - sc-96461-SH from Santa Cruz Biotechnology
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INSC shRNA (h) Lentiviral Particles - sc-96461-V from Santa Cruz Biotechnology
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MISSION® esiRNA - EHU122521 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN10698 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND10698 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR08418 from Sigma-Aldrich
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INSC siRNA (Human) - CRJ7754 from Cohesion Biosciences
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INSC - MBS8203785 from MyBioSource
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shRNA set against Human INSC (NM_001031853.3) - SHH319809 from Creative biogene
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shRNA set against Human INSC(NM_001042536.1) - SHL178752 from Creative biogene
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shRNA set against Human INSC(NM_001031853.3) - SHL178788 from Creative biogene
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Human INSC siRNA - orb278255 from Biorbyt
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INSC shRNA Plasmid (Human) - CHJ7754 from Cohesion Biosciences
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INSC miRNA 3'UTR clone - MiUTR1H-04959 from Creative biogene
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INSC miRNA 3'UTR clone - MiUTR1H-04960 from Creative biogene
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