| Gene Symbol |
INSC
|
| Entrez Gene |
387755
|
| Alt Symbol |
-
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
inscuteable homolog (Drosophila)
|
| Other Description |
inscuteable spindle orientation adaptor protein|protein inscuteable homolog
|
| Swissprots |
Q4AC97 A0PJX5 Q4AC96 Q3C1V6 Q4AC98 Q1MX18 Q4AC95 Q1MX19
|
| Accessions |
Q1MX18 AB231744 BAE46891 AB231745 BAE17133 AB231746 BAE17134 AB231747 BAE17135 AB231748 BAE17136 AB231749 BAE46892 AB236158 BAE93463 AB236159 BAE93464 BC117561 BC127700 AAI27701 BC156332 AAI56333 BC157083 AAI57084 BU147420 DY654442 XM_006718227 XP_006718290 XM_011520082 XP_011518384 XM_011520083 XP_011518385 XM_011520084 XP_011518386 XM_011520085 XP_011518387 XM_011520086 XP_011518388 XM_011520087 XP_011518389 XM_011520088 XP_011518390 XR_930868 NM_001031853 NP_001027024 NM_001042536 NP_001036001 NM_001278313 NP_001265242 NM_001278314 NP_001265243 NM_001278315 NP_001265244 NM_001278316 NP_001265245
|
| Function |
May function as an adapter linking the Par3 complex to the GPSM1/GPSM2 complex. Involved in spindle orientation during mitosis it may regulate cell proliferation and differentiation in the developing nervous system. May play a role in the asymmetric division of fibroblasts and participate in the process of stratification of the squamous epithelium. {ECO:0000269|PubMed:16458856}.
|
| Subcellular Location |
Cytoplasm. Note=Localizes to the apical cortex of mitotic epidermal cells and to the apical side of neuronal progenitor cells. {ECO:0000250}.
|
| Tissue Specificity |
Isoform 1 is expressed in various tissues with stronger expression in liver, kidney and small intestine. Isoform 2 is abundantly expressed in small intestine and to a lower extent in lung and pancreas. {ECO:0000269|PubMed:12469229, ECO:0000269|PubMed:16458856}.
|