| Gene Symbol |
URM1
|
| Entrez Gene |
81605
|
| Alt Symbol |
C9orf74
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
ubiquitin related modifier 1
|
| Other Description |
ubiquitin related modifier 1 homolog|ubiquitin-related modifier 1|ubiquitin-related modifier 1 homolog
|
| Swissprots |
B3KMH3 B4DV08 Q9BTM9 Q5T4B4
|
| Accessions |
EAW87782 EAW87783 EAW87784 EAW87785 EAW87786 Q9BTM9 AI872337 AK001880 BAG50985 AK097029 AK300877 BAG62520 BC003581 AAH03581 BC011620 BI823604 D83200 DA691216 HG502453 NM_001135947 NP_001129419 NM_001265582 NP_001252511 NM_030914 NP_112176 NR_049743
|
| Function |
Acts as a sulfur carrier required for 2-thiolation of mcm(5)S(2)U at tRNA wobble positions of cytosolic tRNA(Lys), tRNA(Glu) and tRNA(Gln). Serves as sulfur donor in tRNA 2- thiolation reaction by being thiocarboxylated (-COSH) at its C- terminus by MOCS3. The sulfur is then transferred to tRNA to form 2-thiolation of mcm(5)S(2)U. Also acts as a ubiquitin-like protein (UBL) that is covalently conjugated via an isopeptide bond to lysine residues of target proteins such as MOCS3, ATPBD3, CTU2, USP15 and CAS. The thiocarboxylated form serves as substrate for conjugation and oxidative stress specifically induces the formation of UBL-protein conjugates. {ECO:0000255|HAMAP- Rule:MF_03048, ECO:0000269|PubMed:19017811, ECO:0000269|PubMed:21209336}.
|
| Subcellular Location |
Cytoplasm.
|
| Top Pathways |
Sulfur relay system
|
![Western Blot: URM1 Overexpression Lysate (Adult Normal) [NBL1-17633] Left-Empty vector transfected control cell lysate (HEK293 cell lysate); Right -Over-expression Lysate for URM1.](http://www.bioprodhub.com/system/product_images/cel_products/5/sub_2/9437_URM1%2520Overexpression%2520Lysate%2520(Adult%2520Normal)-Western%2520Blot-NBL1-17633-img0002.jpg)