URM1

Gene Symbol	URM1
Entrez Gene	81605
Alt Symbol	C9orf74
Species	Human
Gene Type	protein-coding
Description	ubiquitin related modifier 1
Other Description	ubiquitin related modifier 1 homolog|ubiquitin-related modifier 1|ubiquitin-related modifier 1 homolog
Swissprots	B3KMH3 B4DV08 Q9BTM9 Q5T4B4
Accessions	EAW87782 EAW87783 EAW87784 EAW87785 EAW87786 Q9BTM9 AI872337 AK001880 BAG50985 AK097029 AK300877 BAG62520 BC003581 AAH03581 BC011620 BI823604 D83200 DA691216 HG502453 NM_001135947 NP_001129419 NM_001265582 NP_001252511 NM_030914 NP_112176 NR_049743
Function	Acts as a sulfur carrier required for 2-thiolation of mcm(5)S(2)U at tRNA wobble positions of cytosolic tRNA(Lys), tRNA(Glu) and tRNA(Gln). Serves as sulfur donor in tRNA 2- thiolation reaction by being thiocarboxylated (-COSH) at its C- terminus by MOCS3. The sulfur is then transferred to tRNA to form 2-thiolation of mcm(5)S(2)U. Also acts as a ubiquitin-like protein (UBL) that is covalently conjugated via an isopeptide bond to lysine residues of target proteins such as MOCS3, ATPBD3, CTU2, USP15 and CAS. The thiocarboxylated form serves as substrate for conjugation and oxidative stress specifically induces the formation of UBL-protein conjugates. {ECO:0000255|HAMAP- Rule:MF_03048, ECO:0000269|PubMed:19017811, ECO:0000269|PubMed:21209336}.
Subcellular Location	Cytoplasm.
Top Pathways	Sulfur relay system

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Active human Urm1 full length protein - ab190041 from Abcam Category Protein Prices $408.00 Sizes 250 µg Source E. coli Species Human

Human Urm1 full length protein - ab105598 from Abcam Category Protein Source E. coli Species Human

Recombinant Human URM1 Protein - NBP1-51064 from Novus Biologicals Category Protein Prices $269.00, $729.00 Sizes 100 µg, 500 µg Source E. coli Species Human

URM1 Recombinant Protein - P3428 from Novus Biologicals Category Protein Prices $549.00 Sizes 100 µg Species Human

Recombinant Human URM1 Isoform 1, CF - UL-950-250 from R&D Systems Category Protein Source E. coli-derived,

Human URM1 protein - orb169530 from Biorbyt Category Protein Prices $170.00, $289.00 Sizes 5 μg, 20 μg Species Human

URM1 protein (His tag) - 80R-1752 from Fitzgerald Category Protein Prices $255.00 Sizes 100 µg Source E.coli

URM1 (1-101, His-tag) - AR09934PU-L from Acris Antibodies Category Protein Prices $790.00 Sizes 500 µg Source E. coli Species Human

URM1 (1-101, His-tag) - AR09934PU-N from Acris Antibodies Category Protein Prices $340.00 Sizes 100 µg Source E. coli Species Human

URM1 - P3428 from Acris Antibodies Category Protein Prices $500.00 Sizes 100 µg Species Human

Ubiquitin Related Modifier 1, Human Recombinant - 228-12942-1 from RayBiotech Category Protein Prices $118.00 Sizes 1 µg Species Human

Recombinant Human Ubiquitin Related Modifier 1 - 228-12942-2 from RayBiotech Category Protein Prices $189.00 Sizes 2 µg Source Escherichia Coli. Species Human

Recombinant Human Ubiquitin Related Modifier 1 - 228-12942-3 from RayBiotech Category Protein Prices $2,880.00 Sizes 3 µg Source Escherichia Coli. Species Human

URM1, 1-101aa, Human, His tag, E.coli - 01-P0994 from ARP American Research Products Category Protein Prices $179.00, $369.00, $849.00 Sizes 20 µg, 100 µg, 500 µg Species Human

URM1 fusion protein - ag7664 from Proteintech Group Category Protein Source E. coli-derived, PET28a Species Human

URM1 fusion protein - Ag7448 from Proteintech Group Category Protein Prices $199.00 Sizes 50 μg Source E. coli -derived, PGEX-4T Species Human

URM1 Human - PRPS-195 from NeoScientific Category Protein Prices $65.00, $169.00, $3,510.00 Sizes 5 µg, 20 µg, 1 mg Source Escherichia Coli. Species Human

Recombinant Human URM1 Protein - BP002009-PRO-188 from Syd Labs Category Protein Prices $160.00, $2,700.00 Sizes 20 µg, 1 mg Source E. coli-derived. Species Human

URM1, 1-101aa, Recombinant Protein - GWB-P1044D from Genway Biotech Category Protein Prices $300.00, $900.00 Sizes 100 μg, 500 μg Source E.coli Species Human

URM1 Human Protein - GWB-BSP707 from Genway Biotech Category Protein Prices $75.00, $165.00, $3,230.00 Sizes 5 μg, 20 μg, 1000 μg Source Escherichia Coli. Species Human

Recombiant Hmuan Ubiquitin Related Modifier 1, His-tagged - URM1-63H from Creative Biomart Category Protein

Recombinant Human URM1, His-tagged - URM1-31676TH from Creative Biomart Category Protein Source E. coli

URM1 - NKX-544 from Reagent Proteins Category Protein Prices $364.00, $2,898.00 Sizes 20.00 µg, 1 mg Source E.coli

URM1 1-101aa - CMB-827 from Reagent Proteins Category Protein Prices $469.00, $889.00 Sizes 100.00 µg, 500 µg Source E.coli Species Human

Recombinant Human Ubiquitin-related modifier 1 homolog(URM1) - CSB-YP861135HU CSB-EP861135HU CSB-BP861135HU CSB-MP861135HU from Cusabio Category Protein Source Yeast or E.coli or Baculovirus or Mammalian cell Species Human

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