| Gene Symbol |
RNF212
|
| Entrez Gene |
285498
|
| Alt Symbol |
ZHP3
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
ring finger protein 212
|
| Other Description |
probable E3 SUMO-protein ligase RNF212
|
| Swissprots |
C9J8N0 Q8N8U7 Q495C1 Q8IY99 Q86W82 Q495C0
|
| Accessions |
EAW82610 EAW82611 EAW82612 EAW82613 EAW82614 Q495C1 AK096160 BAC04714 AK124578 AK310043 BC036250 AAH36250 BC050356 AAH50356 BC101258 AAI01259 BC101259 AAI01260 BC101260 AAI01261 BC101261 AAI01262 BG701603 BI460105 DB159979 XM_005272274 XP_005272331 XM_011513438 XP_011511740 XM_011513439 XP_011511741 XM_011513440 XP_011511742 XM_011513441 XP_011511743 XM_011513442 XP_011511744 XM_011513443 XP_011511745 XM_011513444 XP_011511746 XM_011513445 XP_011511747 XM_011513446 XP_011511748 XR_246609 XR_924933 XR_924936 XR_924937 NM_001131034 NP_001124506 NM_001193318 NP_001180247 NM_194439 NP_919420
|
| Function |
SUMO E3 ligase that acts as a regulator of crossing-over during meiosis: required to couple chromosome synapsis to the formation of crossover-specific recombination complexes. Localizes to recombination sites and stabilizes meiosis-specific recombination factors, such as MutS-gamma complex proteins (MSH4 and MSH5) and TEX11. May mediate sumoylation of target proteins MSH4 and/or MSH5, leading to enhance their binding to recombination sites. Acts as a limiting factor for crossover designation and/or reinforcement and plays an antagonist role with CCNB1IP1/HEI10 in the regulation of meiotic recombination (By similarity). {ECO:0000250}.
|
| Subcellular Location |
Nucleus {ECO:0000250}. Chromosome {ECO:0000250}. Note=Associates to the synaptonemal complex. Localizes to a minority of double-strand breaks (DSBs) sites. Marks crossover sites during midpachynema (By similarity). {ECO:0000250}.
|