RNF212
| Gene Symbol | RNF212 |
|---|---|
| Entrez Gene | 285498 |
| Alt Symbol | ZHP3 |
| Species | Human |
| Gene Type | protein-coding |
| Description | ring finger protein 212 |
| Other Description | probable E3 SUMO-protein ligase RNF212 |
| Swissprots | C9J8N0 Q8N8U7 Q495C1 Q8IY99 Q86W82 Q495C0 |
| Accessions | EAW82610 EAW82611 EAW82612 EAW82613 EAW82614 Q495C1 AK096160 BAC04714 AK124578 AK310043 BC036250 AAH36250 BC050356 AAH50356 BC101258 AAI01259 BC101259 AAI01260 BC101260 AAI01261 BC101261 AAI01262 BG701603 BI460105 DB159979 XM_005272274 XP_005272331 XM_011513438 XP_011511740 XM_011513439 XP_011511741 XM_011513440 XP_011511742 XM_011513441 XP_011511743 XM_011513442 XP_011511744 XM_011513443 XP_011511745 XM_011513444 XP_011511746 XM_011513445 XP_011511747 XM_011513446 XP_011511748 XR_246609 XR_924933 XR_924936 XR_924937 NM_001131034 NP_001124506 NM_001193318 NP_001180247 NM_194439 NP_919420 |
| Function | SUMO E3 ligase that acts as a regulator of crossing-over during meiosis: required to couple chromosome synapsis to the formation of crossover-specific recombination complexes. Localizes to recombination sites and stabilizes meiosis-specific recombination factors, such as MutS-gamma complex proteins (MSH4 and MSH5) and TEX11. May mediate sumoylation of target proteins MSH4 and/or MSH5, leading to enhance their binding to recombination sites. Acts as a limiting factor for crossover designation and/or reinforcement and plays an antagonist role with CCNB1IP1/HEI10 in the regulation of meiotic recombination (By similarity). {ECO:0000250}. |
| Subcellular Location | Nucleus {ECO:0000250}. Chromosome {ECO:0000250}. Note=Associates to the synaptonemal complex. Localizes to a minority of double-strand breaks (DSBs) sites. Marks crossover sites during midpachynema (By similarity). {ECO:0000250}. |
RNF212 CRISPR/Cas9 KO Plasmid (h) - sc-410417 from Santa Cruz Biotechnology
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RNF212 HDR Plasmid (h) - sc-410417-HDR from Santa Cruz Biotechnology
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RNF212 Double Nickase Plasmid (h) - sc-410417-NIC from Santa Cruz Biotechnology
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RNF212 Double Nickase Plasmid (h2) - sc-410417-NIC-2 from Santa Cruz Biotechnology
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RNF212 CRISPR Activation Plasmid (h) - sc-410417-ACT from Santa Cruz Biotechnology
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RNF212 CRISPR Activation Plasmid (h2) - sc-410417-ACT-2 from Santa Cruz Biotechnology
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RNF212 Lentiviral Activation Particles (h) - sc-410417-LAC from Santa Cruz Biotechnology
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RNF212 Lentiviral Activation Particles (h2) - sc-410417-LAC-2 from Santa Cruz Biotechnology
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RNF212 siRNA (h) - sc-88993 from Santa Cruz Biotechnology
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RNF212 shRNA Plasmid (h) - sc-88993-SH from Santa Cruz Biotechnology
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RNF212 shRNA (h) Lentiviral Particles - sc-88993-V from Santa Cruz Biotechnology
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RNF212 RNAi - H00285498-R01 from Novus Biologicals
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MISSION® esiRNA - EHU103741 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN18418 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND18418 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR12669 from Sigma-Aldrich
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RNF212 siRNA (Human) - CRJ7101 from Cohesion Biosciences
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RNF212 - MBS8202289 from MyBioSource
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shRNA set against Human RNF212 (NM_194439.4) - SHH397136 from Creative biogene
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Human RNF212 siRNA - orb277602 from Biorbyt
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RNF212 shRNA Plasmid (Human) - CHJ7101 from Cohesion Biosciences
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RNF212 miRNA 3'UTR clone - MiUTR3H-12269 from Creative biogene
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RNF212 miRNA 3'UTR clone - MiUTR3H-12270 from Creative biogene
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