Gene Symbol | RNF212 |
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Entrez Gene | 285498 |
Alt Symbol | ZHP3 |
Species | Human |
Gene Type | protein-coding |
Description | ring finger protein 212 |
Other Description | probable E3 SUMO-protein ligase RNF212 |
Swissprots | C9J8N0 Q8N8U7 Q495C1 Q8IY99 Q86W82 Q495C0 |
Accessions | EAW82610 EAW82611 EAW82612 EAW82613 EAW82614 Q495C1 AK096160 BAC04714 AK124578 AK310043 BC036250 AAH36250 BC050356 AAH50356 BC101258 AAI01259 BC101259 AAI01260 BC101260 AAI01261 BC101261 AAI01262 BG701603 BI460105 DB159979 XM_005272274 XP_005272331 XM_011513438 XP_011511740 XM_011513439 XP_011511741 XM_011513440 XP_011511742 XM_011513441 XP_011511743 XM_011513442 XP_011511744 XM_011513443 XP_011511745 XM_011513444 XP_011511746 XM_011513445 XP_011511747 XM_011513446 XP_011511748 XR_246609 XR_924933 XR_924936 XR_924937 NM_001131034 NP_001124506 NM_001193318 NP_001180247 NM_194439 NP_919420 |
Function | SUMO E3 ligase that acts as a regulator of crossing-over during meiosis: required to couple chromosome synapsis to the formation of crossover-specific recombination complexes. Localizes to recombination sites and stabilizes meiosis-specific recombination factors, such as MutS-gamma complex proteins (MSH4 and MSH5) and TEX11. May mediate sumoylation of target proteins MSH4 and/or MSH5, leading to enhance their binding to recombination sites. Acts as a limiting factor for crossover designation and/or reinforcement and plays an antagonist role with CCNB1IP1/HEI10 in the regulation of meiotic recombination (By similarity). {ECO:0000250}. |
Subcellular Location | Nucleus {ECO:0000250}. Chromosome {ECO:0000250}. Note=Associates to the synaptonemal complex. Localizes to a minority of double-strand breaks (DSBs) sites. Marks crossover sites during midpachynema (By similarity). {ECO:0000250}. |
Human LOC285498 full length protein - ab166204 from Abcam
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Human LOC285498 protein fragment - ab166205 from Abcam
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RNF212 Antibody Blocking Peptide - LS-E16004 from LifeSpan Bioscience
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RNF212 Antibody Blocking Peptide - LS-E26740 from LifeSpan Bioscience
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Recombinant Human RNF212 Protein - H00285498-P01 from Novus Biologicals
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Recombinant Human RNF212 Protein - H00285498-Q01 from Novus Biologicals
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RNF212 blocking peptide - GTX88757-PEP from GeneTex
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RNF212 Blocking Peptide - 33R-4823 from Fitzgerald
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LOC285498 Peptide - AC21-1577-P from Abcore
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RNF212 - H00285498-P01-10 from Acris Antibodies
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RNF212 - H00285498-P01-25 from Acris Antibodies
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RNF212 - H00285498-Q01-10 from Acris Antibodies
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RNF212 - H00285498-Q01-25 from Acris Antibodies
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RNF212 Peptide - 46-893P from ProSci
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RNF212 fusion protein - Ag15553 from Proteintech Group
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RNF212 fusion protein - ag15457 from Proteintech Group
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Recombinant Human RNF212, His-tagged - RNF212-2343H from Creative Biomart
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Recombinant Human RING finger protein 212(RNF212) - CSB-YP019872HU CSB-EP019872HU CSB-BP019872HU CSB-MP019872HU from Cusabio
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RNF212, Peptide - MBS426995 from MyBioSource
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RNF212 Recombinant Protein Antigen - NBP2-49259PEP from Novus Biologicals
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RNF212 Peptide, Human - M34GP13418H from Creative Peptides
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RING finger protein 212 (RNF212), Recombinant Protein - MBS1480473 from MyBioSource
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RNF212 Recombinant Protein (Human) (OPCA04833) - OPCA04833 from Aviva Systems Biology
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Human RNF212 protein - orb54346 from Biorbyt
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RNF212 Immunizing peptide - orb50455 from Biorbyt
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