DEDD2

Gene Symbol DEDD2
Entrez Gene 162989
Alt Symbol FLAME-3
Species Human
Gene Type protein-coding
Description death effector domain containing 2
Other Description DED-containing protein FLAME-3|DNA-binding death effector domain-containing protein 2|FADD-like anti-apoptotic molecule 3
Swissprots Q8TAA8 Q96D35 Q8NES1 Q8NBR2 Q8WXF8
Accessions EAW57110 EAW57111 EAW57112 Q8WXF8 AA635978 AF443591 AAL48220 AF457575 AAM10835 AK075328 BAC11551 AK130203 AK307895 AY125488 AAM95240 BC013372 AAH13372 BC027930 AAH27930 BM908148 BX374729 BX458265 CN373297 CR984238 CT000394 DA821401 DC337066 HY033141 HY033487 XM_011526569 XP_011524871 XM_011526570 XP_011524872 XM_011526571 XP_011524873 XM_011526572 XP_011524874 XR_935758 NM_001270614 NP_001257543 NM_001270615 NP_001257544 NM_133328 NP_579874 NR_073046 NR_073047 NR_073048 NR_073049 NR_073050 NR_073051 NR_073052
Function May play a critical role in death receptor-induced apoptosis and may target CASP8 and CASP10 to the nucleus. May regulate degradation of intermediate filaments during apoptosis. May play a role in the general transcription machinery in the nucleus and might be an important regulator of the activity of GTF3C3.
Subcellular Location Nucleus, nucleolus {ECO:0000269|PubMed:11965497}. Note=Nuclear, accumulated in subnuclear structures resembling nucleoli.
Tissue Specificity Expressed in most tissues. High levels were found in liver, kidney, heart, ovary, spleen, testes, skeletal muscle and peripheral blood leukocytes. Expression was absent or low in colon and small intestine. Expression is relatively high in the tumor cell lines chronic myologenous leukemia K-562 and the colorectal adenocarcinoma SW480. Expression is moderate in the cervical carcinoma HeLa, the Burkitt's lymphoma Raji, the lung carcinoma A-549, and the melanoma G-361. In contrast, two leukemia cell lines, HL-60 (promyelocytic leukemia) and MOLT-4 (lymphoblastic leukemia), show relatively low levels. {ECO:0000269|PubMed:11741985, ECO:0000269|PubMed:11965497}.

DEDD2 (A-18) - sc-79429 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

DEDD2 (G-13) - sc-79431 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
DEDD2 (G-13): sc-79431. Western blot analysis of DEDD2 expression in mouse skeletal muscle tissue extract.

Anti-DEDD2 antibody - ab36858 from Abcam

Prices $370.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Lane 1 : Anti-DEDD2 antibody (ab36858) at 0.5 µg/mlLane 2 : Anti-DEDD2 antibody (ab36858) at 1 µg/mlLane 3 : Anti-DEDD2 antibody (ab36858) at 2 µg/mlLane 1 : RAW264.7 cell lysate Lane 2 : RAW264.7 cell lysate Lane 3 : RAW264.7 cell lysate Lysates/proteins at 15 µg/ml per lane.SecondaryAnti-rabbit IgG HRP at 1/10000 dilution

Anti-DEDD2 antibody - ab197091 from Abcam

Prices $370.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal
All lanes : Anti-DEDD2 antibody (ab197091) at 1/500 dilutionLane 1 : Jurkat lysateLane 2 : RAW lysate

Anti-DEDD2 antibody - ab104350 from Abcam

Prices $370.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Anti-DEDD2 antibody (ab104350) at 1 µg/ml + Human fetal lung lysate at 10 µg

Anti-DEDD2 antibody - N-terminal - ab200445 from Abcam

Host Rabbit
Clonality Polyclonal
All lanes : Anti-DEDD2 antibody - N-terminal (ab200445) at 1/1000 dilutionLane 1 : Mouse brain total cell extractLane 2 : Mouse thymus total cell extractLane 3 : HeLa total cell extract

Anti-FLAME-3 / DEDD2 Antibody (aa144-129) - LS-C6391 from LifeSpan Bioscience

Prices $325.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal

Anti-FLAME-3 / DEDD2 Antibody (N-Terminus) - LS-C14831 from LifeSpan Bioscience

Prices $425.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-FLAME-3 / DEDD2 Antibody (aa144-129) - LS-C40698 from LifeSpan Bioscience

Prices $275.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-FLAME-3 / DEDD2 Antibody (aa144-129) - LS-C83754 from LifeSpan Bioscience

Prices $335.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Anti-FLAME-3 / DEDD2 Antibody (aa210-228) - LS-C148266 from LifeSpan Bioscience

Prices $335.00
Sizes 50 µl
Host Rabbit
Clonality Polyclonal

Anti-FLAME-3 / DEDD2 Antibody (aa175-193) - LS-C148267 from LifeSpan Bioscience

Prices $335.00
Sizes 50 µl
Host Rabbit
Clonality Polyclonal

Anti-FLAME-3 / DEDD2 Antibody (aa179-228) - LS-C116494 from LifeSpan Bioscience

Prices $365.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
DEDD2 antibody LS-C116494 Western blot of Fetal lung lysate.

Anti-FLAME-3 / DEDD2 Antibody (N-Terminus) - LS-C19473 from LifeSpan Bioscience

Prices $325.00, $890.00
Sizes 100 µg, 500 µg
Host Rabbit
Clonality Polyclonal
Western blot of DEDD2 in RAW264.7 cell lysate with DEDD2 antibody at (A) 0.5, (B) 1 and (C) 2 ug/ml.

DEDD2 Antibody - NB100-56137 from Novus Biologicals

Prices $129.00, $199.00
Sizes 25 µl, 50 µl
Host Rabbit
Clonality Polyclonal

DEDD2 Antibody - NB100-56138 from Novus Biologicals

Prices $129.00, $199.00
Sizes 25 µl, 50 µl
Host Rabbit
Clonality Polyclonal

DEDD2 Antibody - NBP1-91827 from Novus Biologicals

Prices $419.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Western Blot: DEDD2 Antibody [NBP1-91827] - Lane 1: Marker [kDa] 250, 130, 95, 72, 55, 36, 28, 17, 10<br/>Lane 2: Negative control (vector only transfected HEK293T lysate)<br/>Lane 3: Over-expression lysate (Co-expressed with a C-terminal myc-DDK tag (~3.1 kDa) in mammalian HEK293T cells, LY408867)

DEDD2 Antibody - NBP1-91828 from Novus Biologicals

Prices $419.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Immunohistochemistry-Paraffin: DEDD2 Antibody [NBP1-91828] - Staining of human cerebellum shows strong cytoplasmic positivity in Purkinje cells.

DEDD2 Antibody - NBP1-76451 from Novus Biologicals

Prices $329.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Western Blot: DEDD2 Antibody [NBP1-76451] - Western blot Analysis of DEDD2 in RAW264.7 cell lysate using NBP1-76451 at (A) 0.5, (B) 1 and (C) 2 ug/ml.

DEDD2 Antibody - NB100-93565 from Novus Biologicals

Prices $279.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

DEDD2 Polyclonal Antibody - bs-7063R from Bioss

Prices $269.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Anti-DEDD2 antibody produced in rabbit - HPA043554 from Sigma-Aldrich

Prices $429.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
<B>Immunohistochemistry</B><BR/>Anti-DEDD2: <B>Cat. No. HPA043554</B>: Immunohistochemical staining of human cerebellum shows strong cytoplasmic positivity in Purkinje cells.

Anti-DEDD2 antibody produced in rabbit - HPA043419 from Sigma-Aldrich

Prices $429.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
<B>Immunohistochemistry</B><BR/>Anti-DEDD2: <B>Cat. No. HPA043419</B>: Immunohistochemical staining of human kidney shows moderate membranous and cytoplasmic positivity in renal tubules.

Anti-DEDD2 (106-120) antibody produced in rabbit - SAB1103473 from Sigma-Aldrich

Prices $298.50
Sizes 200 µl
Host Rabbit
Clonality Polyclonal
<B>Immunoblotting</B><BR/>Lysate of HEK-293T cells overexpressing human DEDD2 was separated on SDS-PAGE, blotted with Anti-DEDD2 (106-120) (<B>Cat. No.SAB1103473</B>) and developed using Goat Anti-Rabbit IgG-Peroxidase (<B>Cat. No. A0545</B>) and a chemiluminescent substrate.<BR/><B>Lanes</B><BR/>1. Antibody dilution 1:500

Anti-DEDD2 (141-155) antibody produced in rabbit - SAB1103474 from Sigma-Aldrich

Prices $298.50
Sizes 200 µl
Host Rabbit
Clonality Polyclonal
<B>Immunoblotting</B><BR/>Lysate of HEK-293T cells overexpressing human DEDD2 was separated on SDS-PAGE, blotted with Anti-DEDD2 (141-155) (<B>Cat. No.SAB1103474</B>) and developed using Goat Anti-Rabbit IgG-Peroxidase (<B>Cat. No. A0545</B>) and a chemiluminescent substrate.<BR/><B>Lanes</B><BR/>1. Antibody dilution 1:1,000<BR/>2. Antibody dilution 1:1,000 + DEDD2 immunizing peptide (human, 141-155)
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