DEDD2

Gene Symbol	DEDD2
Entrez Gene	162989
Alt Symbol	FLAME-3
Species	Human
Gene Type	protein-coding
Description	death effector domain containing 2
Other Description	DED-containing protein FLAME-3|DNA-binding death effector domain-containing protein 2|FADD-like anti-apoptotic molecule 3
Swissprots	Q8TAA8 Q96D35 Q8NES1 Q8NBR2 Q8WXF8
Accessions	EAW57110 EAW57111 EAW57112 Q8WXF8 AA635978 AF443591 AAL48220 AF457575 AAM10835 AK075328 BAC11551 AK130203 AK307895 AY125488 AAM95240 BC013372 AAH13372 BC027930 AAH27930 BM908148 BX374729 BX458265 CN373297 CR984238 CT000394 DA821401 DC337066 HY033141 HY033487 XM_011526569 XP_011524871 XM_011526570 XP_011524872 XM_011526571 XP_011524873 XM_011526572 XP_011524874 XR_935758 NM_001270614 NP_001257543 NM_001270615 NP_001257544 NM_133328 NP_579874 NR_073046 NR_073047 NR_073048 NR_073049 NR_073050 NR_073051 NR_073052
Function	May play a critical role in death receptor-induced apoptosis and may target CASP8 and CASP10 to the nucleus. May regulate degradation of intermediate filaments during apoptosis. May play a role in the general transcription machinery in the nucleus and might be an important regulator of the activity of GTF3C3.
Subcellular Location	Nucleus, nucleolus {ECO:0000269|PubMed:11965497}. Note=Nuclear, accumulated in subnuclear structures resembling nucleoli.
Tissue Specificity	Expressed in most tissues. High levels were found in liver, kidney, heart, ovary, spleen, testes, skeletal muscle and peripheral blood leukocytes. Expression was absent or low in colon and small intestine. Expression is relatively high in the tumor cell lines chronic myologenous leukemia K-562 and the colorectal adenocarcinoma SW480. Expression is moderate in the cervical carcinoma HeLa, the Burkitt's lymphoma Raji, the lung carcinoma A-549, and the melanoma G-361. In contrast, two leukemia cell lines, HL-60 (promyelocytic leukemia) and MOLT-4 (lymphoblastic leukemia), show relatively low levels. {ECO:0000269|PubMed:11741985, ECO:0000269|PubMed:11965497}.

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human Death effector domain containing 2 Gene - orb142822 from Biorbyt Prices $255.00 Sizes 10 μg Species Human

DEDD2 - MBS1267506 from MyBioSource Species Human Accession BC027930

DEDD2 - MBS1274179 from MyBioSource Species Human Accession BC013372

Human DEDD2 Gene cDNA clone plasmid - HG15497-G from Sino Biological Species Human

Human DEDD2 Gene ORF cDNA clone expression plasmid, N-HA tag - HG15497-NY from Sino Biological Species Human

Human DEDD2 Gene ORF cDNA clone expression plasmid, C-GFPSpark tag - HG15497-ACG from Sino Biological Species Human

Human DEDD2 Gene ORF cDNA clone expression plasmid, C-Flag tag - HG15497-CF from Sino Biological Species Human

Human DEDD2 Gene ORF cDNA clone expression plasmid, N-Myc tag - HG15497-NM from Sino Biological Species Human

Human DEDD2 Gene ORF cDNA clone expression plasmid, C-Myc tag - HG15497-CM from Sino Biological Species Human

Human DEDD2 Gene ORF cDNA clone expression plasmid, C-OFPSpark tag - HG15497-ACR from Sino Biological Species Human

Human DEDD2 Gene ORF cDNA clone expression plasmid, N-OFPSpark tag - HG15497-ANR from Sino Biological Species Human

Human DEDD2 Gene ORF cDNA clone expression plasmid - HG15497-UT from Sino Biological Species Human

Human DEDD2 Gene ORF cDNA clone expression plasmid, N-GFPSpark tag - HG15497-ANG from Sino Biological Species Human

Human DEDD2 Gene ORF cDNA clone expression plasmid, N-His tag - HG15497-NH from Sino Biological Species Human

Human DEDD2 Gene ORF cDNA clone expression plasmid, C-His tag - HG15497-CH from Sino Biological Species Human

Human DEDD2 Gene ORF cDNA clone expression plasmid, C-HA tag - HG15497-CY from Sino Biological Species Human

Human DEDD2 Gene ORF cDNA clone expression plasmid, N-Flag tag - HG15497-NF from Sino Biological Species Human

Human DEDD2 ORF Clone (BC013372) - CDCS416721 from Creative biogene Species Human Accession Q8WXF8

Human DEDD2 ORF Clone (BC027930) - CDCS416722 from Creative biogene Species Human Accession Q8WXF8

Human DEDD2 ORF clone (BC027930) - CDCB158101 from Creative biogene Species Human

Search more