DEDD2

Gene Symbol	DEDD2
Entrez Gene	162989
Alt Symbol	FLAME-3
Species	Human
Gene Type	protein-coding
Description	death effector domain containing 2
Other Description	DED-containing protein FLAME-3|DNA-binding death effector domain-containing protein 2|FADD-like anti-apoptotic molecule 3
Swissprots	Q8TAA8 Q96D35 Q8NES1 Q8NBR2 Q8WXF8
Accessions	EAW57110 EAW57111 EAW57112 Q8WXF8 AA635978 AF443591 AAL48220 AF457575 AAM10835 AK075328 BAC11551 AK130203 AK307895 AY125488 AAM95240 BC013372 AAH13372 BC027930 AAH27930 BM908148 BX374729 BX458265 CN373297 CR984238 CT000394 DA821401 DC337066 HY033141 HY033487 XM_011526569 XP_011524871 XM_011526570 XP_011524872 XM_011526571 XP_011524873 XM_011526572 XP_011524874 XR_935758 NM_001270614 NP_001257543 NM_001270615 NP_001257544 NM_133328 NP_579874 NR_073046 NR_073047 NR_073048 NR_073049 NR_073050 NR_073051 NR_073052
Function	May play a critical role in death receptor-induced apoptosis and may target CASP8 and CASP10 to the nucleus. May regulate degradation of intermediate filaments during apoptosis. May play a role in the general transcription machinery in the nucleus and might be an important regulator of the activity of GTF3C3.
Subcellular Location	Nucleus, nucleolus {ECO:0000269|PubMed:11965497}. Note=Nuclear, accumulated in subnuclear structures resembling nucleoli.
Tissue Specificity	Expressed in most tissues. High levels were found in liver, kidney, heart, ovary, spleen, testes, skeletal muscle and peripheral blood leukocytes. Expression was absent or low in colon and small intestine. Expression is relatively high in the tumor cell lines chronic myologenous leukemia K-562 and the colorectal adenocarcinoma SW480. Expression is moderate in the cervical carcinoma HeLa, the Burkitt's lymphoma Raji, the lung carcinoma A-549, and the melanoma G-361. In contrast, two leukemia cell lines, HL-60 (promyelocytic leukemia) and MOLT-4 (lymphoblastic leukemia), show relatively low levels. {ECO:0000269|PubMed:11741985, ECO:0000269|PubMed:11965497}.

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human DEDD2 full length protein - ab132433 from Abcam Category Protein Source Wheat germ Species Human

Human DEDD2 peptide - ab39755 from Abcam Category Peptide Species Human

FLAME-3 / DEDD2 Antibody Blocking Peptide - LS-E18916 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

FLAME-3 / DEDD2 Antibody Blocking Peptide - LS-E30005 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 50 µg

DEDD2 Recombinant Protein - H00162989-P01 from Novus Biologicals Category Protein

DEDD2 Blocking Peptide - NBP1-76451PEP from Novus Biologicals Category Peptide Prices $129.00 Sizes 50 µg Species Human

DEDD2 Blocking Peptide - 33R-7309 from Fitzgerald Category Peptide Prices $130.00 Sizes 100 µg

DEDD2 - H00162989-P01 from Acris Antibodies Category Protein Prices $340.00 Sizes 2 µg Species Human

DEDD2 Control Peptide - AP30285CP-N from Acris Antibodies Category Peptide Prices $135.00 Sizes 50 µg

DEDD2 Peptide - 3071P from ProSci Category Peptide Species Human

DEDD2 fusion protein - ag5724 from Proteintech Group Category Protein Source E. coli-derived, PET28a Species Human

Recombinant Human DNA-binding death effector domain-containing protein 2(DEDD2) - CSB-YP837874HU CSB-EP837874HU CSB-BP837874HU CSB-MP837874HU from Cusabio Category Protein Source Yeast or E.coli or Baculovirus or Mammalian cell Species Human

DEDD2 Protein - abx163304 from Abbexa Category Protein Species Human, Mouse

DEDD2 Protein - NBP1-91828PEP from Novus Biologicals Category Protein Prices $209.00 Sizes 100 µl Species Human

DEDD2 Protein - NBP1-91827PEP from Novus Biologicals Category Protein Prices $209.00 Sizes 100 µl Species Human

DEDD2-Blocking-Peptide-N-Term - BP21939a from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

DEDD2-Blocking-Peptide-Center - BP21912c from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

DEDD2 Peptide, Human - M34GP04178H from Creative Peptides Category Peptide Source Synthetic. Species Human

DNA-binding death effector domain-containing protein 2 (DEDD2), Recombinant Protein - MBS1401659 from MyBioSource Category Protein Prices $1,085.00, $1,085.00, $1,315.00, $1,315.00, $1,710.00, $1,710.00, $2,170.00, $2,170.00 Sizes 500 µg (E-Coli), 50 µg (Baculovirus), 500 µg (Yeast), 50 µg (Mammalian-Cell), 1 mg (E-Coli), 100 µg (Baculovirus), 1 mg (Yeast), 100 µg (Mammalian-Cell) Source E Coli or Yeast or Baculovirus or Mammalian Cell Species Human

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