| Gene Symbol |
DEDD2
|
| Entrez Gene |
162989
|
| Alt Symbol |
FLAME-3
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
death effector domain containing 2
|
| Other Description |
DED-containing protein FLAME-3|DNA-binding death effector domain-containing protein 2|FADD-like anti-apoptotic molecule 3
|
| Swissprots |
Q8TAA8 Q96D35 Q8NES1 Q8NBR2 Q8WXF8
|
| Accessions |
EAW57110 EAW57111 EAW57112 Q8WXF8 AA635978 AF443591 AAL48220 AF457575 AAM10835 AK075328 BAC11551 AK130203 AK307895 AY125488 AAM95240 BC013372 AAH13372 BC027930 AAH27930 BM908148 BX374729 BX458265 CN373297 CR984238 CT000394 DA821401 DC337066 HY033141 HY033487 XM_011526569 XP_011524871 XM_011526570 XP_011524872 XM_011526571 XP_011524873 XM_011526572 XP_011524874 XR_935758 NM_001270614 NP_001257543 NM_001270615 NP_001257544 NM_133328 NP_579874 NR_073046 NR_073047 NR_073048 NR_073049 NR_073050 NR_073051 NR_073052
|
| Function |
May play a critical role in death receptor-induced apoptosis and may target CASP8 and CASP10 to the nucleus. May regulate degradation of intermediate filaments during apoptosis. May play a role in the general transcription machinery in the nucleus and might be an important regulator of the activity of GTF3C3.
|
| Subcellular Location |
Nucleus, nucleolus {ECO:0000269|PubMed:11965497}. Note=Nuclear, accumulated in subnuclear structures resembling nucleoli.
|
| Tissue Specificity |
Expressed in most tissues. High levels were found in liver, kidney, heart, ovary, spleen, testes, skeletal muscle and peripheral blood leukocytes. Expression was absent or low in colon and small intestine. Expression is relatively high in the tumor cell lines chronic myologenous leukemia K-562 and the colorectal adenocarcinoma SW480. Expression is moderate in the cervical carcinoma HeLa, the Burkitt's lymphoma Raji, the lung carcinoma A-549, and the melanoma G-361. In contrast, two leukemia cell lines, HL-60 (promyelocytic leukemia) and MOLT-4 (lymphoblastic leukemia), show relatively low levels. {ECO:0000269|PubMed:11741985, ECO:0000269|PubMed:11965497}.
|
![Western Blot: DEDD2 Overexpression Lysate (Adult Normal) [NBL1-09816] Left-Empty vector transfected control cell lysate (HEK293 cell lysate); Right -Over-expression Lysate for DEDD2.](http://www.bioprodhub.com/system/product_images/cel_products/5/sub_2/3879_DEDD2%2520Overexpression%2520Lysate%2520(Adult%2520Normal)-Western%2520Blot-NBL1-09816-img0002.jpg)