GLIS2

Gene Symbol	GLIS2
Entrez Gene	84662
Alt Symbol	NKL, NPHP7
Species	Human
Gene Type	protein-coding
Description	GLIS family zinc finger 2
Other Description	GLI-similar 2\|GLI-similar protein 2\|Kruppel-like zinc finger protein GLIS2\|nephrocystin-7\|neuronal Krueppel-like protein\|zinc finger protein GLIS2
Swissprots	Q9BZE0 B3KX84
Accessions	EAW85317 EAW85318 Q9BZE0 AF325914 AAK00954 AK095566 BAG53086 AK096936 AK124985 AK126918 BAG54396 BC033763 BC141548 AAI41549 BC146548 AAI46549 XM_005255641 XP_005255698 XM_005255642 XP_005255699 XM_006725240 XP_006725303 XM_006725241 XP_006725304 NM_032575 NP_115964
Function	Can act either as a transcriptional repressor or as a transcriptional activator, depending on the cell context. Acts as a repressor of the Hedgehog signaling pathway (By similarity). Represses the Hedgehog-dependent expression of Wnt4 (By similarity). Necessary to maintain the differentiated epithelial phenotype in renal cells through the inhibition of SNAI1, which itself induces the epithelial-to-mesenchymal transition (By similarity). Represses transcriptional activation mediated by CTNNB1 in the Wnt signaling pathway. May act by recruiting the corepressors CTBP1 and HDAC3. May be involved in neuron differentiation (By similarity). {ECO:0000250}.
Subcellular Location	Nucleus speckle {ECO:0000250}. Cytoplasm {ECO:0000250}.
Tissue Specificity	Expressed at high levels in kidney and at low levels in heart, lung and placenta. Expressed in colon. {ECO:0000269\|PubMed:11738817, ECO:0000269\|PubMed:17289029}.

GLIS2 (E-17) - sc-68546 from Santa Cruz Biotechnology

Prices	$279.00
Sizes	200 µg/ml
Host	Goat
Clonality	Polyclonal

GLIS2 (E-17): sc-68546. Western blot analysis of GLIS2 expression in non-transfected: sc-117752 (A) and mouse GLIS2 transfected: sc-120501 (B) 293T whole cell lysates.

GLIS2 (H-219) - sc-367883 from Santa Cruz Biotechnology

Prices	$279.00
Sizes	200 µg/ml
Host	Rabbit
Clonality	Polyclonal

GLIS2 (N-18) - sc-68548 from Santa Cruz Biotechnology

Prices	$279.00
Sizes	200 µg/ml
Host	Goat
Clonality	Polyclonal

GLIS2 (P-25) - sc-133625 from Santa Cruz Biotechnology

Prices	$279.00
Sizes	50 µg/0.5 ml
Host	Rabbit
Clonality	Polyclonal

GLIS2 (P-25): sc-133625. Western blot analysis of GLIS2 expression in Hep G2 whole cell lysate.

Anti-GliS2 antibody - ab48861 from Abcam

Prices	$370.00
Sizes	100 µg
Host	Rabbit
Clonality	Polyclonal

Anti-GliS2 antibody (ab48861) at 2.5 µg/ml (in 5% skimmed milk/PBS) + HepG2 cell lysate at 10 µgSecondaryHRP conjugated anti-Rabbit IgG at 1/50000 dilution

Anti-GliS2 antibody - C-terminal - ab199914 from Abcam

Host	Rabbit
Clonality	Polyclonal

All lanes : Anti-GliS2 antibody - C-terminal (ab199914) at 1/1000 dilutionLane 1 : Total cell extract of HeLa cellsLane 2 : Total cell extract of Jurkat cells

Anti-GLIS2 Antibody (aa173-202, AP) - LS-C235724 from LifeSpan Bioscience

Prices	$545.00
Sizes	200 µl
Host	Rabbit
Clonality	Polyclonal

Anti-GLIS2 Antibody (aa173-202, APC) - LS-C235722 from LifeSpan Bioscience

Prices	$545.00
Sizes	200 µl
Host	Rabbit
Clonality	Polyclonal

Anti-GLIS2 Antibody (aa173-202, Biotin) - LS-C235723 from LifeSpan Bioscience

Prices	$545.00
Sizes	200 µl
Host	Rabbit
Clonality	Polyclonal

Anti-GLIS2 Antibody (aa183-232) - LS-C29879 from LifeSpan Bioscience

Prices	$365.00
Sizes	50 µg
Host	Rabbit
Clonality	Polyclonal

Anti-GLIS2 Antibody (aa83-132) - LS-C31233 from LifeSpan Bioscience

Prices	$325.00
Sizes	100 µg
Host	Rabbit
Clonality	Polyclonal

Anti-GLIS2 Antibody (aa173-202, PE) - LS-C235726 from LifeSpan Bioscience

Prices	$545.00
Sizes	200 µl
Host	Rabbit
Clonality	Polyclonal

Anti-GLIS2 Antibody (aa173-202, FITC) - LS-C235725 from LifeSpan Bioscience

Prices	$545.00
Sizes	200 µl
Host	Rabbit
Clonality	Polyclonal

Anti-GLIS2 Antibody (aa173-202, Azide-free, HRP) - LS-C249077 from LifeSpan Bioscience

Prices	$545.00
Sizes	200 µl
Host	Rabbit
Clonality	Polyclonal

Anti-GLIS2 Antibody (aa172-202) - LS-C321653 from LifeSpan Bioscience

Prices	$345.00
Sizes	200 µl
Host	Rabbit
Clonality	Polyclonal

Anti-GLIS2 Antibody (aa173-202) - LS-C166504 from LifeSpan Bioscience

Prices	$295.00
Sizes	400 µl
Host	Rabbit
Clonality	Polyclonal

GLIS2 Antibody western blot of NCI-H292 cell line lysates (35 ug/lane). The GLIS2 antibody detected the GLIS2 protein (arrow).

Anti-GLIS2 Antibody (Internal) - LS-C336253 from LifeSpan Bioscience

Prices	$345.00
Sizes	100 µg
Host	Rabbit
Clonality	Polyclonal

Immunohistochemistry of GLIS2 in mouse kidney tissue with GLIS2 antibody at 5 ug/ml.

GliS2 Antibody - NBP2-41311 from Novus Biologicals

Prices	$329.00
Sizes	100 µg
Host	Rabbit
Clonality	Polyclonal

Western Blot: GliS2 Antibody [NBP2-41311] - Western blot analysis of GLIS2 in K562 cell lysate with GLIS2 antibody at 1 ug/ml.

Rabbit Anti-GLIS2 Polyclonal Antibody - bs-11566R from Bioss

Prices	$245.00
Sizes	100 µl
Host	Rabbit
Clonality	Polyclonal

Rabbit Anti-GLIS2 Polyclonal Antibody, ALEXA FLUOR® 350 Conjugated - bs-11566R-A350 from Bioss

Prices	$325.00
Sizes	100 µl
Host	Rabbit
Clonality	Polyclonal

Rabbit Anti-GLIS2 Polyclonal Antibody, ALEXA FLUOR® 488 Conjugated - bs-11566R-A488 from Bioss

Prices	$325.00
Sizes	100 µl
Host	Rabbit
Clonality	Polyclonal

Rabbit Anti-GLIS2 Polyclonal Antibody, ALEXA FLUOR® 555 Conjugated - bs-11566R-A555 from Bioss

Prices	$325.00
Sizes	100 µl
Host	Rabbit
Clonality	Polyclonal

Rabbit Anti-GLIS2 Polyclonal Antibody, ALEXA FLUOR® 647 Conjugated - bs-11566R-A647 from Bioss

Prices	$325.00
Sizes	100 µl
Host	Rabbit
Clonality	Polyclonal

Rabbit Anti-GLIS2 Polyclonal Antibody, Cy3 Conjugated - bs-11566R-Cy3 from Bioss

Prices	$345.00
Sizes	100 µl
Host	Rabbit
Clonality	Polyclonal

Rabbit Anti-GLIS2 Polyclonal Antibody, Cy5 Conjugated - bs-11566R-Cy5 from Bioss

Prices	$345.00
Sizes	100 µl
Host	Rabbit
Clonality	Polyclonal

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