GLIS2

Gene Symbol GLIS2
Entrez Gene 84662
Alt Symbol NKL, NPHP7
Species Human
Gene Type protein-coding
Description GLIS family zinc finger 2
Other Description GLI-similar 2|GLI-similar protein 2|Kruppel-like zinc finger protein GLIS2|nephrocystin-7|neuronal Krueppel-like protein|zinc finger protein GLIS2
Swissprots Q9BZE0 B3KX84
Accessions EAW85317 EAW85318 Q9BZE0 AF325914 AAK00954 AK095566 BAG53086 AK096936 AK124985 AK126918 BAG54396 BC033763 BC141548 AAI41549 BC146548 AAI46549 XM_005255641 XP_005255698 XM_005255642 XP_005255699 XM_006725240 XP_006725303 XM_006725241 XP_006725304 NM_032575 NP_115964
Function Can act either as a transcriptional repressor or as a transcriptional activator, depending on the cell context. Acts as a repressor of the Hedgehog signaling pathway (By similarity). Represses the Hedgehog-dependent expression of Wnt4 (By similarity). Necessary to maintain the differentiated epithelial phenotype in renal cells through the inhibition of SNAI1, which itself induces the epithelial-to-mesenchymal transition (By similarity). Represses transcriptional activation mediated by CTNNB1 in the Wnt signaling pathway. May act by recruiting the corepressors CTBP1 and HDAC3. May be involved in neuron differentiation (By similarity). {ECO:0000250}.
Subcellular Location Nucleus speckle {ECO:0000250}. Cytoplasm {ECO:0000250}.
Tissue Specificity Expressed at high levels in kidney and at low levels in heart, lung and placenta. Expressed in colon. {ECO:0000269|PubMed:11738817, ECO:0000269|PubMed:17289029}.

Human GliS2 full length protein - ab153554 from Abcam

Category Protein
Source Wheat germ
Species Human
ab153554 on a 12.5% SDS-PAGE stained with Coomassie Blue.

GLIS2 Antibody Blocking Peptide - LS-E4239 from LifeSpan Bioscience

Category Peptide
Prices $145.00
Sizes 100 µg

GLIS2 Antibody Blocking Peptide - LS-E10456 from LifeSpan Bioscience

Category Peptide
Prices $145.00
Sizes 100 µg

GLIS2 Antibody Blocking Peptide - LS-E10457 from LifeSpan Bioscience

Category Peptide
Prices $145.00
Sizes 100 µg

Recombinant Human GliS2 Protein - H00084662-P01 from Novus Biologicals

Category Protein
Prices $319.00
Sizes 2 µg
Source Wheat Germ
Species Human

GLIS2-Antibody-Center-Blocking-Peptide - BP16510c from Abgent, a WuXi AppTec company

Category Peptide
Prices $80.00
Sizes 100 µg

GLIS2 - H00084662-P01 from Acris Antibodies

Category Protein
Prices $310.00
Sizes 2 µg
Species Human

GLIS2 Peptide - 8091P from ProSci

Category Peptide
Species Human
Western blot analysis of GLIS2 in C2C12 cell lysate with GLIS2 antibody at 1 μg/ml in (A) the absence and (B) the presence of blocking peptide.

Recombinant Human Zinc finger protein GLIS2(GLIS2) - CSB-YP861185HU CSB-EP861185HU CSB-BP861185HU CSB-MP861185HU from Cusabio

Category Protein
Source Yeast or E.coli or Baculovirus or Mammalian cell
Species Human

Zinc finger protein GLIS2 (GLIS2) , Recombinant Protein - MBS1403348 from MyBioSource

Category Protein
Prices $2,170.00, $2,170.00, $2,630.00, $2,630.00
Sizes 1 mg (E-Coli), 100 µg (Baculovirus), 1 mg (Yeast), 100 µg (Mammalian-Cell)
Source E Coli or Yeast or Baculovirus or Mammalian Cell
Species Human

GLIS2 Peptide, Human - M34GP06323H from Creative Peptides

Category Peptide
Source Synthetic.
Species Human

GliS2 Recombinant Protein Antigen - NBP2-54964PEP from Novus Biologicals

Category Protein
Prices $199.00
Sizes 100 µl
Source E.coli
Species Human
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