Gene Symbol | GLIS2 |
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Entrez Gene | 84662 |
Alt Symbol | NKL, NPHP7 |
Species | Human |
Gene Type | protein-coding |
Description | GLIS family zinc finger 2 |
Other Description | GLI-similar 2|GLI-similar protein 2|Kruppel-like zinc finger protein GLIS2|nephrocystin-7|neuronal Krueppel-like protein|zinc finger protein GLIS2 |
Swissprots | Q9BZE0 B3KX84 |
Accessions | EAW85317 EAW85318 Q9BZE0 AF325914 AAK00954 AK095566 BAG53086 AK096936 AK124985 AK126918 BAG54396 BC033763 BC141548 AAI41549 BC146548 AAI46549 XM_005255641 XP_005255698 XM_005255642 XP_005255699 XM_006725240 XP_006725303 XM_006725241 XP_006725304 NM_032575 NP_115964 |
Function | Can act either as a transcriptional repressor or as a transcriptional activator, depending on the cell context. Acts as a repressor of the Hedgehog signaling pathway (By similarity). Represses the Hedgehog-dependent expression of Wnt4 (By similarity). Necessary to maintain the differentiated epithelial phenotype in renal cells through the inhibition of SNAI1, which itself induces the epithelial-to-mesenchymal transition (By similarity). Represses transcriptional activation mediated by CTNNB1 in the Wnt signaling pathway. May act by recruiting the corepressors CTBP1 and HDAC3. May be involved in neuron differentiation (By similarity). {ECO:0000250}. |
Subcellular Location | Nucleus speckle {ECO:0000250}. Cytoplasm {ECO:0000250}. |
Tissue Specificity | Expressed at high levels in kidney and at low levels in heart, lung and placenta. Expressed in colon. {ECO:0000269|PubMed:11738817, ECO:0000269|PubMed:17289029}. |
Human GliS2 full length protein - ab153554 from Abcam
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GLIS2 Antibody Blocking Peptide - LS-E4239 from LifeSpan Bioscience
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GLIS2 Antibody Blocking Peptide - LS-E10456 from LifeSpan Bioscience
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GLIS2 Antibody Blocking Peptide - LS-E10457 from LifeSpan Bioscience
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Recombinant Human GliS2 Protein - H00084662-P01 from Novus Biologicals
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GLIS2-Antibody-Center-Blocking-Peptide - BP16510c from Abgent, a WuXi AppTec company
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GLIS2 - H00084662-P01 from Acris Antibodies
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GLIS2 Peptide - 8091P from ProSci
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Recombinant Human Zinc finger protein GLIS2(GLIS2) - CSB-YP861185HU CSB-EP861185HU CSB-BP861185HU CSB-MP861185HU from Cusabio
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Zinc finger protein GLIS2 (GLIS2) , Recombinant Protein - MBS1403348 from MyBioSource
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GLIS2 Peptide, Human - M34GP06323H from Creative Peptides
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GliS2 Recombinant Protein Antigen - NBP2-54964PEP from Novus Biologicals
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