Gene Symbol | GLIS2 |
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Entrez Gene | 84662 |
Alt Symbol | NKL, NPHP7 |
Species | Human |
Gene Type | protein-coding |
Description | GLIS family zinc finger 2 |
Other Description | GLI-similar 2|GLI-similar protein 2|Kruppel-like zinc finger protein GLIS2|nephrocystin-7|neuronal Krueppel-like protein|zinc finger protein GLIS2 |
Swissprots | Q9BZE0 B3KX84 |
Accessions | EAW85317 EAW85318 Q9BZE0 AF325914 AAK00954 AK095566 BAG53086 AK096936 AK124985 AK126918 BAG54396 BC033763 BC141548 AAI41549 BC146548 AAI46549 XM_005255641 XP_005255698 XM_005255642 XP_005255699 XM_006725240 XP_006725303 XM_006725241 XP_006725304 NM_032575 NP_115964 |
Function | Can act either as a transcriptional repressor or as a transcriptional activator, depending on the cell context. Acts as a repressor of the Hedgehog signaling pathway (By similarity). Represses the Hedgehog-dependent expression of Wnt4 (By similarity). Necessary to maintain the differentiated epithelial phenotype in renal cells through the inhibition of SNAI1, which itself induces the epithelial-to-mesenchymal transition (By similarity). Represses transcriptional activation mediated by CTNNB1 in the Wnt signaling pathway. May act by recruiting the corepressors CTBP1 and HDAC3. May be involved in neuron differentiation (By similarity). {ECO:0000250}. |
Subcellular Location | Nucleus speckle {ECO:0000250}. Cytoplasm {ECO:0000250}. |
Tissue Specificity | Expressed at high levels in kidney and at low levels in heart, lung and placenta. Expressed in colon. {ECO:0000269|PubMed:11738817, ECO:0000269|PubMed:17289029}. |
GLIS2 CRISPR/Cas9 KO Plasmid (h) - sc-408299 from Santa Cruz Biotechnology
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GLIS2 HDR Plasmid (h) - sc-408299-HDR from Santa Cruz Biotechnology
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GLIS2 Double Nickase Plasmid (h) - sc-408299-NIC from Santa Cruz Biotechnology
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GLIS2 Double Nickase Plasmid (h2) - sc-408299-NIC-2 from Santa Cruz Biotechnology
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GLIS2 CRISPR Activation Plasmid (h) - sc-408299-ACT from Santa Cruz Biotechnology
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GLIS2 CRISPR Activation Plasmid (h2) - sc-408299-ACT-2 from Santa Cruz Biotechnology
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GLIS2 Lentiviral Activation Particles (h) - sc-408299-LAC from Santa Cruz Biotechnology
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GLIS2 Lentiviral Activation Particles (h2) - sc-408299-LAC-2 from Santa Cruz Biotechnology
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GLIS2 siRNA (h) - sc-75142 from Santa Cruz Biotechnology
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GLIS2 shRNA Plasmid (h) - sc-75142-SH from Santa Cruz Biotechnology
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GLIS2 shRNA (h) Lentiviral Particles - sc-75142-V from Santa Cruz Biotechnology
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GliS2 RNAi - H00084662-R01 from Novus Biologicals
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MISSION® esiRNA - EHU030211 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN9348 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND9348 from Sigma-Aldrich
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GLIS2 siRNA (Human) - CRJ3565 from Cohesion Biosciences
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GLIS2 - MBS8222873 from MyBioSource
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shRNA set against Human GLIS2 (NM_032575.2) - SHH301834 from Creative biogene
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shRNA set against Human GLIS2(NM_032575.2) - SHH087113 from Creative biogene
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Human GLIS2 siRNA - orb274066 from Biorbyt
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GLIS2 shRNA Plasmid (Human) - CHJ3565 from Cohesion Biosciences
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GLIS2 miRNA 3'UTR clone - MiUTR1H-04065 from Creative biogene
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