GLIS2

Gene Symbol GLIS2
Entrez Gene 84662
Alt Symbol NKL, NPHP7
Species Human
Gene Type protein-coding
Description GLIS family zinc finger 2
Other Description GLI-similar 2|GLI-similar protein 2|Kruppel-like zinc finger protein GLIS2|nephrocystin-7|neuronal Krueppel-like protein|zinc finger protein GLIS2
Swissprots Q9BZE0 B3KX84
Accessions EAW85317 EAW85318 Q9BZE0 AF325914 AAK00954 AK095566 BAG53086 AK096936 AK124985 AK126918 BAG54396 BC033763 BC141548 AAI41549 BC146548 AAI46549 XM_005255641 XP_005255698 XM_005255642 XP_005255699 XM_006725240 XP_006725303 XM_006725241 XP_006725304 NM_032575 NP_115964
Function Can act either as a transcriptional repressor or as a transcriptional activator, depending on the cell context. Acts as a repressor of the Hedgehog signaling pathway (By similarity). Represses the Hedgehog-dependent expression of Wnt4 (By similarity). Necessary to maintain the differentiated epithelial phenotype in renal cells through the inhibition of SNAI1, which itself induces the epithelial-to-mesenchymal transition (By similarity). Represses transcriptional activation mediated by CTNNB1 in the Wnt signaling pathway. May act by recruiting the corepressors CTBP1 and HDAC3. May be involved in neuron differentiation (By similarity). {ECO:0000250}.
Subcellular Location Nucleus speckle {ECO:0000250}. Cytoplasm {ECO:0000250}.
Tissue Specificity Expressed at high levels in kidney and at low levels in heart, lung and placenta. Expressed in colon. {ECO:0000269|PubMed:11738817, ECO:0000269|PubMed:17289029}.

GLIS2 CRISPR/Cas9 KO Plasmid (h) - sc-408299 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

GLIS2 HDR Plasmid (h) - sc-408299-HDR from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

GLIS2 Double Nickase Plasmid (h) - sc-408299-NIC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

GLIS2 Double Nickase Plasmid (h2) - sc-408299-NIC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

GLIS2 CRISPR Activation Plasmid (h) - sc-408299-ACT from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

GLIS2 CRISPR Activation Plasmid (h2) - sc-408299-ACT-2 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

GLIS2 Lentiviral Activation Particles (h) - sc-408299-LAC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

GLIS2 Lentiviral Activation Particles (h2) - sc-408299-LAC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

GLIS2 siRNA (h) - sc-75142 from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

GLIS2 shRNA Plasmid (h) - sc-75142-SH from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

GLIS2 shRNA (h) Lentiviral Particles - sc-75142-V from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

GliS2 RNAi - H00084662-R01 from Novus Biologicals

Category siRNA
Prices $399.00
Sizes 20 nmol
Species Reactivities Human

MISSION® esiRNA - EHU030211 from Sigma-Aldrich

Category siRNA
Prices $140.00, $250.00
Sizes 20 µg, 50 µg

CompoZr® Knockout ZFN Kit - CKOZFN9348 from Sigma-Aldrich

Category ZFN Kit
Prices $4,999.00
Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND9348 from Sigma-Aldrich

Category ZFN Kit
Prices $3,999.00
Sizes 1 kt

GLIS2 siRNA (Human) - CRJ3565 from Cohesion Biosciences

Category siRNA
Prices $340.00, $510.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

GLIS2 - MBS8222873 from MyBioSource

Prices $365.00, $515.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

shRNA set against Human GLIS2 (NM_032575.2) - SHH301834 from Creative biogene

Category siRNA
Species Reactivities Human

shRNA set against Human GLIS2(NM_032575.2) - SHH087113 from Creative biogene

Category siRNA
Species Reactivities Human

Human GLIS2 siRNA - orb274066 from Biorbyt

Category siRNA
Prices $485.00, $629.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

GLIS2 shRNA Plasmid (Human) - CHJ3565 from Cohesion Biosciences

Category siRNA
Prices $500.00, $750.00
Sizes 150 µg, 300 µg
Species Reactivities Human

GLIS2 miRNA 3'UTR clone - MiUTR1H-04065 from Creative biogene

Species Reactivities Human
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