GLIS2

Gene Symbol GLIS2
Entrez Gene 84662
Alt Symbol NKL, NPHP7
Species Human
Gene Type protein-coding
Description GLIS family zinc finger 2
Other Description GLI-similar 2|GLI-similar protein 2|Kruppel-like zinc finger protein GLIS2|nephrocystin-7|neuronal Krueppel-like protein|zinc finger protein GLIS2
Swissprots Q9BZE0 B3KX84
Accessions EAW85317 EAW85318 Q9BZE0 AF325914 AAK00954 AK095566 BAG53086 AK096936 AK124985 AK126918 BAG54396 BC033763 BC141548 AAI41549 BC146548 AAI46549 XM_005255641 XP_005255698 XM_005255642 XP_005255699 XM_006725240 XP_006725303 XM_006725241 XP_006725304 NM_032575 NP_115964
Function Can act either as a transcriptional repressor or as a transcriptional activator, depending on the cell context. Acts as a repressor of the Hedgehog signaling pathway (By similarity). Represses the Hedgehog-dependent expression of Wnt4 (By similarity). Necessary to maintain the differentiated epithelial phenotype in renal cells through the inhibition of SNAI1, which itself induces the epithelial-to-mesenchymal transition (By similarity). Represses transcriptional activation mediated by CTNNB1 in the Wnt signaling pathway. May act by recruiting the corepressors CTBP1 and HDAC3. May be involved in neuron differentiation (By similarity). {ECO:0000250}.
Subcellular Location Nucleus speckle {ECO:0000250}. Cytoplasm {ECO:0000250}.
Tissue Specificity Expressed at high levels in kidney and at low levels in heart, lung and placenta. Expressed in colon. {ECO:0000269|PubMed:11738817, ECO:0000269|PubMed:17289029}.

GLIS2 overexpression lysate - LY410031 from Acris Antibodies

Category Cell Lysate
Prices $480.00
Sizes 100 µg

Panoply™ Human GLIS2 Knockdown Stable Cell Line - CSC-DC006323 from Creative biogene

Category Cell Line
Species Human
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