IGF2BP2

Gene Symbol	IGF2BP2
Entrez Gene	10644
Alt Symbol	IMP-2, IMP2, VICKZ2
Species	Human
Gene Type	protein-coding
Description	insulin-like growth factor 2 mRNA binding protein 2
Other Description	IGF-II mRNA-binding protein 2\|IGF2 mRNA-binding protein 2\|VICKZ family member 2\|insulin-like growth factor 2 mRNA-binding protein 2
Swissprots	B3FTN3 A0A4Z0 B3FTN4 B3FTN2 Q9Y6M1
Accessions	CAY39325 EAW78209 EAW78210 EAW78211 Q9Y6M1 AA451676 AF117107 AAD09827 AI336648 AI348863 AK290664 BAF83353 AK296703 BAG59297 AK309611 AW193691 BC021290 AAH21290 BX537583 CD110066 DQ892161 ABM83087 EU176689 ABW03490 EU408701 ACB86625 EU408702 ACB86626 EU408703 ACB86627 EU408704 ACB86628 XM_006713477 XP_006713540 XM_006713478 XP_006713541 XM_011512337 XP_011510639 XM_011512338 XP_011510640 XM_011512339 XP_011510641 XM_011512340 XP_011510642 XM_011512341 XP_011510643 XM_011512342 XP_011510644 XR_427358 NM_001007225 NP_001007226 NM_001291869 NP_001278798 NM_001291872 NP_001278801 NM_001291873 NP_001278802 NM_001291874 NP_001278803 NM_001291875 NP_001278804 NM_006548 NP_006539
Function	RNA-binding factor that recruits target transcripts to cytoplasmic protein-RNA complexes (mRNPs). This transcript 'caging' into mRNPs allows mRNA transport and transient storage. It also modulates the rate and location at which target transcripts encounter the translational apparatus and shields them from endonuclease attacks or microRNA-mediated degradation (By similarity). Binds to the 5'-UTR of the insulin-like growth factor 2 (IGF2) mRNAs. Binding is isoform-specific. Binds to beta- actin/ACTB and MYC transcripts. {ECO:0000250, ECO:0000269\|PubMed:23640942, ECO:0000269\|PubMed:9891060}.
Subcellular Location	Nucleus. Cytoplasm. Note=Localized in cytoplasmic mRNP granules containing untranslated mRNAs. Localizes at the connecting piece and the tail of the spermatozoa. In response to cellular stress, such as oxidative stress, recruited to stress granules.
Tissue Specificity	Expressed in oocytes, granulosa cells of small and growing follicles, Leydig cells, spermatogonia and semen (at protein level). Expressed in testicular cancer (at protein level). Expressed weakly in heart, placenta, skeletal muscle, bone marrow, colon, kidney, salivary glands, testis and pancreas. Detected in fetal liver, fetal ovary, gonocytes and interstitial cells of the testis. {ECO:0000269\|PubMed:10190901, ECO:0000269\|PubMed:16049158}.

IMP2 (D4R2F) Rabbit mAb - 14672 from Cell Signaling Technology

Prices	$246.00
Sizes	100 µl (10 western blots)
Host	Rabbit
Clonality	Monoclonal
Clone	D4R2F

Western blot analysis of extracts from Hep G2, SK-MEL-5, and A-204 cells using IMP2 (D4R2F) Rabbit mAb.

IGF2BP2 (F-12) - sc-377014 from Santa Cruz Biotechnology

Prices	$279.00
Sizes	200 µg/ml
Host	Mouse
Clonality	Monoclonal

IGF2BP2 (F-12): sc-377014. Western blot analysis of IGF2BP2 expression in non-transfected: sc-117752 (A) and human IGF2BP2 transfected: sc-174608 (B) 293T whole cell lysates.

IGF2BP2 (H-70) - sc-292208 from Santa Cruz Biotechnology

Prices	$279.00
Sizes	200 µg/ml
Host	Rabbit
Clonality	Polyclonal

IGF2BP2 (N-13) - sc-99463 from Santa Cruz Biotechnology

Prices	$279.00
Sizes	100 µg/ml
Host	Rabbit
Clonality	Polyclonal

IGF2BP2 (N-13): sc-99463. Western blot analysis of IGF2BP2 expression in non-transfected: sc-117752 (A) and human IGF2BP2 transfected: sc-174608 (B) 293T whole cell lysates.

IGF2BP2 (P-16) - sc-99464 from Santa Cruz Biotechnology

Prices	$279.00
Sizes	100 µg/ml
Host	Rabbit
Clonality	Polyclonal

IGF2BP2 (P-16): sc-99464. Western blot analysis of IGF2BP2 expression in non-transfected 293T: sc-117752 (A), human IGF2BP2 transfected 293T: sc-174608 (B) and Hep G2 (C) whole cell lysates.

Anti-IGF2BP2 antibody - ab151463 from Abcam

Prices	$384.00
Sizes	100 µl
Host	Rabbit
Clonality	Polyclonal

All lanes : Anti-IGF2BP2 antibody (ab151463) at 1/3000 dilutionLane 1 : 293T whole cell lysateLane 2 : A431 whole cell lysateLane 3 : HepG2 whole cell lysateLysates/proteins at 30 µg per lane.

Anti-IGF2BP2 antibody - ab182768 from Abcam

Prices	$376.00
Sizes	100 µl
Host	Rabbit
Clonality	Polyclonal

All lanes : Anti-IGF2BP2 antibody (ab182768) at 1/300 dilutionLane 1 : Human liver cancer tissue lysateLane 2 : Human ovarian cancer tissue lysateLysates/proteins at 40 µg per lane.SecondaryGoat anti Rabbit IgG - H&L (HRP) at 1/10000 dilutiondeveloped using the ECL technique

Anti-IGF2BP2 antibody - ab88414 from Abcam

Prices	$378.00
Sizes	100 µg
Host	Mouse
Clonality	Monoclonal

Anti-IGF2BP2 antibody (ab88414) at 1 µg/ml + K562 lysate at 50 µgSecondaryGoat Anti-Mouse IgG at 1/5000 dilution

Anti-IGF2BP2 antibody - ab77634 from Abcam

Prices	$376.00
Sizes	200 µl
Host	Goat
Clonality	Polyclonal

Anti-IGF2BP2 antibody (ab77634) at 1 µg/ml + HepG2 cell lysate (in RIPA buffer) at 35 µg

Anti-IGF2BP2 antibody - ab117809 from Abcam

Prices	$376.00
Sizes	100 µg
Host	Rabbit
Clonality	Polyclonal

All lanes : Anti-IGF2BP2 antibody (ab117809) at 0.1 µg/mlLane 1 : Whole cell lysate from 293T cells at 50 µgLane 2 : Whole cell lysate from 293T cells at 15 µgLane 3 : Whole cell lysate from Jurkat cells at 50 µgLane 4 : Whole cell lysate from HeLa cells at 50 µgdeveloped using the ECL technique

Anti-IGF2BP2 antibody - ab67434 from Abcam

Prices	$376.00
Sizes	50 µg
Host	Mouse
Clonality	Polyclonal

Anti-IGF2BP2 antibody (ab67434) at 1/500 dilution + human placenta tissue lysate at 25 µgSecondaryGoat Anti-Mouse IgG (H&L)-HRP Conjugate at 1/2500 dilution

Anti-IGF2BP2 antibody - ab107192 from Abcam

Prices	$359.00
Sizes	100 µg
Host	Rabbit
Clonality	Polyclonal

Anti-IGF2BP2 antibody (ab107192) at 1/100 dilution + HepG2 cell line lysate at 35 µg

Anti-IGF2BP2 antibody - ab94594 from Abcam

Prices	$376.00
Sizes	100 µl
Host	Rabbit
Clonality	Polyclonal

Anti-IGF2BP2 antibody (ab94594) at 1 µg/ml (in 5% skim milk / PBS buffer) + HT1080 cell lysate at 10 µgSecondaryHRP conjugated anti-Rabbit IgG at 1/50000 dilution

Anti-IGF2BP2 antibody - ab117827 from Abcam

Prices	$376.00
Sizes	100 µg
Host	Rabbit
Clonality	Polyclonal

Detection of Human IGF2BP2 by Immunoprecipitation in 293T whole cell lysate (1 mg for IP, 20% of IP loaded) using ab117827 at 6 µg/mg of lysate. For subsequent WB detection, another anti Human IGF2BP2 antibody was used. Detection: Chemiluminescence with exposure time of 30 seconds.

Anti-IGF2BP2 antibody [1E3.01E5] - ab128175 from Abcam

Prices	$376.00
Sizes	100 µg
Host	Mouse
Clonality	Monoclonal
Clone	1E3.01E5

All lanes : Anti-IGF2BP2 antibody [1E3.01E5] (ab128175) at 0.04 µg/mlLane 1 : HeLa whole cell lysate at 50 µgLane 2 : HeLa whole cell lysate at 15 µgLane 3 : Jurkat whole cell lysate at 50 µgdeveloped using the ECL technique

Anti-IGF2BP2 antibody [3A3.5F1] - ab128207 from Abcam

Prices	$376.00
Sizes	100 µg
Host	Mouse
Clonality	Monoclonal
Clone	3A3.5F1

All lanes : Anti-IGF2BP2 antibody [3A3.5F1] (ab128207) at 0.04 µg/mlLane 1 : HeLa whole cell lysate at 50 µgLane 2 : HeLa whole cell lysate at 15 µgLane 3 : Jurkat whole cell lysate at 50 µgdeveloped using the ECL technique

Anti-IGF2BP2 antibody [4D10] - ab119041 from Abcam

Prices	$384.00
Sizes	100 µl
Host	Mouse
Clonality	Monoclonal
Clone	4D10

All lanes : Anti-IGF2BP2 antibody [4D10] (ab119041)Lane 1 : HEK293T cell lysate transfected with pCMV6-ENTRY controlLane 2 : HEK293T cell lysate transfected with pCMV6-ENTRY IGF2BP2 cDNALysates/proteins at 5 µg per lane.

Anti-IGF2BP2 antibody [EPR6740(2)] - ab129071 from Abcam

Prices	$385.00
Sizes	100 µl
Host	Rabbit
Clonality	Monoclonal
Clone	EPR6740(2)

All lanes : Anti-IGF2BP2 antibody [EPR6740(2)] (ab129071) at 1/1000 dilutionLane 1 : 293T cell lysateLane 2 : Caco 2 cell lysateLysates/proteins at 10 µg per lane.SecondaryGoat anti-Rabbit HRP at 1/2000 dilution

Anti-IGF2BP2 antibody [EPR6741(B)] - ab124930 from Abcam

Prices	$385.00
Sizes	100 µl
Host	Rabbit
Clonality	Monoclonal
Clone	EPR6741(B)

All lanes : Anti-IGF2BP2 antibody [EPR6741(B)] (ab124930) at 1/1000 dilutionLane 1 : 293T cell lysateLane 2 : Caco2 cell lysateLane 3 : HepG2 cell lysateLane 4 : SH-SY5Y cell lysateLysates/proteins at 10 µg per lane.SecondaryHRP-conjugated goat anti-rabbit at 1/2000 dilution

Anti-IGF2BP2 Antibody (aa141-384, Biotin) - LS-C302735 from LifeSpan Bioscience

Prices	$455.00
Sizes	100 µg
Host	Rabbit
Clonality	Polyclonal

Anti-IGF2BP2 Antibody (aa530-556) - LS-C165146 from LifeSpan Bioscience

Prices	$295.00
Sizes	400 µl
Host	Rabbit
Clonality	Polyclonal

IGF2BP2 antibody immunohistochemistry of formalin-fixed and paraffin-embedded human spleen tissue followed by peroxidase-conjugated secondary antibody and DAB staining.

Anti-IGF2BP2 Antibody (aa293-557, FITC) - LS-C303534 from LifeSpan Bioscience

Prices	$495.00
Sizes	100 µg
Host	Rabbit
Clonality	Polyclonal

Anti-IGF2BP2 Antibody - LS-C308418 from LifeSpan Bioscience

Prices	$455.00
Sizes	50 µg
Host	Mouse
Clonality	Polyclonal

Anti-IGF2BP2 Antibody - LS-C308419 from LifeSpan Bioscience

Prices	$455.00
Sizes	100 µg
Host	Mouse
Clonality	Monoclonal

Anti-IGF2BP2 Antibody - LS-C310722 from LifeSpan Bioscience

Prices	$475.00
Sizes	100 µg
Host	Rabbit
Clonality	Polyclonal

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