| Gene Symbol | IGF2BP2 |
|---|---|
| Entrez Gene | 10644 |
| Alt Symbol | IMP-2, IMP2, VICKZ2 |
| Species | Human |
| Gene Type | protein-coding |
| Description | insulin-like growth factor 2 mRNA binding protein 2 |
| Other Description | IGF-II mRNA-binding protein 2|IGF2 mRNA-binding protein 2|VICKZ family member 2|insulin-like growth factor 2 mRNA-binding protein 2 |
| Swissprots | B3FTN3 A0A4Z0 B3FTN4 B3FTN2 Q9Y6M1 |
| Accessions | CAY39325 EAW78209 EAW78210 EAW78211 Q9Y6M1 AA451676 AF117107 AAD09827 AI336648 AI348863 AK290664 BAF83353 AK296703 BAG59297 AK309611 AW193691 BC021290 AAH21290 BX537583 CD110066 DQ892161 ABM83087 EU176689 ABW03490 EU408701 ACB86625 EU408702 ACB86626 EU408703 ACB86627 EU408704 ACB86628 XM_006713477 XP_006713540 XM_006713478 XP_006713541 XM_011512337 XP_011510639 XM_011512338 XP_011510640 XM_011512339 XP_011510641 XM_011512340 XP_011510642 XM_011512341 XP_011510643 XM_011512342 XP_011510644 XR_427358 NM_001007225 NP_001007226 NM_001291869 NP_001278798 NM_001291872 NP_001278801 NM_001291873 NP_001278802 NM_001291874 NP_001278803 NM_001291875 NP_001278804 NM_006548 NP_006539 |
| Function | RNA-binding factor that recruits target transcripts to cytoplasmic protein-RNA complexes (mRNPs). This transcript 'caging' into mRNPs allows mRNA transport and transient storage. It also modulates the rate and location at which target transcripts encounter the translational apparatus and shields them from endonuclease attacks or microRNA-mediated degradation (By similarity). Binds to the 5'-UTR of the insulin-like growth factor 2 (IGF2) mRNAs. Binding is isoform-specific. Binds to beta- actin/ACTB and MYC transcripts. {ECO:0000250, ECO:0000269|PubMed:23640942, ECO:0000269|PubMed:9891060}. |
| Subcellular Location | Nucleus. Cytoplasm. Note=Localized in cytoplasmic mRNP granules containing untranslated mRNAs. Localizes at the connecting piece and the tail of the spermatozoa. In response to cellular stress, such as oxidative stress, recruited to stress granules. |
| Tissue Specificity | Expressed in oocytes, granulosa cells of small and growing follicles, Leydig cells, spermatogonia and semen (at protein level). Expressed in testicular cancer (at protein level). Expressed weakly in heart, placenta, skeletal muscle, bone marrow, colon, kidney, salivary glands, testis and pancreas. Detected in fetal liver, fetal ovary, gonocytes and interstitial cells of the testis. {ECO:0000269|PubMed:10190901, ECO:0000269|PubMed:16049158}. |