IGF2BP2

Gene Symbol IGF2BP2
Entrez Gene 10644
Alt Symbol IMP-2, IMP2, VICKZ2
Species Human
Gene Type protein-coding
Description insulin-like growth factor 2 mRNA binding protein 2
Other Description IGF-II mRNA-binding protein 2|IGF2 mRNA-binding protein 2|VICKZ family member 2|insulin-like growth factor 2 mRNA-binding protein 2
Swissprots B3FTN3 A0A4Z0 B3FTN4 B3FTN2 Q9Y6M1
Accessions CAY39325 EAW78209 EAW78210 EAW78211 Q9Y6M1 AA451676 AF117107 AAD09827 AI336648 AI348863 AK290664 BAF83353 AK296703 BAG59297 AK309611 AW193691 BC021290 AAH21290 BX537583 CD110066 DQ892161 ABM83087 EU176689 ABW03490 EU408701 ACB86625 EU408702 ACB86626 EU408703 ACB86627 EU408704 ACB86628 XM_006713477 XP_006713540 XM_006713478 XP_006713541 XM_011512337 XP_011510639 XM_011512338 XP_011510640 XM_011512339 XP_011510641 XM_011512340 XP_011510642 XM_011512341 XP_011510643 XM_011512342 XP_011510644 XR_427358 NM_001007225 NP_001007226 NM_001291869 NP_001278798 NM_001291872 NP_001278801 NM_001291873 NP_001278802 NM_001291874 NP_001278803 NM_001291875 NP_001278804 NM_006548 NP_006539
Function RNA-binding factor that recruits target transcripts to cytoplasmic protein-RNA complexes (mRNPs). This transcript 'caging' into mRNPs allows mRNA transport and transient storage. It also modulates the rate and location at which target transcripts encounter the translational apparatus and shields them from endonuclease attacks or microRNA-mediated degradation (By similarity). Binds to the 5'-UTR of the insulin-like growth factor 2 (IGF2) mRNAs. Binding is isoform-specific. Binds to beta- actin/ACTB and MYC transcripts. {ECO:0000250, ECO:0000269|PubMed:23640942, ECO:0000269|PubMed:9891060}.
Subcellular Location Nucleus. Cytoplasm. Note=Localized in cytoplasmic mRNP granules containing untranslated mRNAs. Localizes at the connecting piece and the tail of the spermatozoa. In response to cellular stress, such as oxidative stress, recruited to stress granules.
Tissue Specificity Expressed in oocytes, granulosa cells of small and growing follicles, Leydig cells, spermatogonia and semen (at protein level). Expressed in testicular cancer (at protein level). Expressed weakly in heart, placenta, skeletal muscle, bone marrow, colon, kidney, salivary glands, testis and pancreas. Detected in fetal liver, fetal ovary, gonocytes and interstitial cells of the testis. {ECO:0000269|PubMed:10190901, ECO:0000269|PubMed:16049158}.

IGF2BP2 CRISPR/Cas9 KO Plasmid (h) - sc-404985 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

IGF2BP2 HDR Plasmid (h) - sc-404985-HDR from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

IGF2BP2 Double Nickase Plasmid (h) - sc-404985-NIC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

IGF2BP2 Double Nickase Plasmid (h2) - sc-404985-NIC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

IGF2BP2 CRISPR Activation Plasmid (h) - sc-404985-ACT from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

IGF2BP2 CRISPR Activation Plasmid (h2) - sc-404985-ACT-2 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

IGF2BP2 Lentiviral Activation Particles (h) - sc-404985-LAC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

IGF2BP2 Lentiviral Activation Particles (h2) - sc-404985-LAC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

IGF2BP2 siRNA (h) - sc-78065 from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

IGF2BP2 shRNA Plasmid (h) - sc-78065-SH from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

IGF2BP2 shRNA (h) Lentiviral Particles - sc-78065-V from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

IMP2/IGF2BP2 RNAi - H00010644-R01 from Novus Biologicals

Category siRNA
Prices $399.00
Sizes 20 nmol
Species Reactivities Human

CompoZr® Knockout ZFN Kit - CKOZFN10516 from Sigma-Aldrich

Category ZFN Kit
Prices $4,999.00
Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND10516 from Sigma-Aldrich

Category ZFN Kit
Prices $3,999.00
Sizes 1 kt

IGF2BP2 siRNA (Human) - CRH7254 from Cohesion Biosciences

Category siRNA
Prices $340.00, $510.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

IMP2/IGF2BP2 RNAi - H00010644-R02 from Novus Biologicals

Category siRNA
Prices $399.00
Sizes 20 nmol
Species Reactivities Human

IGF2BP2 - MBS8218541 from MyBioSource

Prices $365.00, $515.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

shRNA set against Human IGF2BP2(NM_001007225.1) - SHL168042 from Creative biogene

Category siRNA
Species Reactivities Human

shRNA set against Human IGF2BP2(NM_006548.4) - SHL168132 from Creative biogene

Category siRNA
Species Reactivities Human

IGF2BP2 shRNA Plasmid (Human) - CHH7254 from Cohesion Biosciences

Category siRNA
Prices $500.00, $750.00
Sizes 150 µg, 300 µg
Species Reactivities Human

IGF2BP2 miRNA 3'UTR clone - MiUTR1H-04834 from Creative biogene

Species Reactivities Human

IGF2BP2 miRNA 3'UTR clone - MiUTR1H-04835 from Creative biogene

Species Reactivities Human
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