MLLT3

Gene Symbol MLLT3
Entrez Gene 4300
Alt Symbol AF9, YEATS3
Species Human
Gene Type protein-coding
Description myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 3
Other Description ALL1-fused gene from chromosome 9 protein|YEATS domain-containing protein 3|myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog); translocated to, 3|myeloid/lymphoid or mixed-lineage leukemia translocated to chromosome 3 protein|protein AF-9
Swissprots B7Z755 B2R7B3 D3DRJ8 P42568 Q8IVB0 B1AMQ2
Accessions EAW58630 EAW58631 EAW58632 P42568 AK128222 AK225957 AK297587 BAH12621 AK301474 BAH13491 AK312914 BAG35760 AW451255 BC030550 BC036089 AAH36089 BI550359 BX649194 CAE46213 D16688 BAA04090 DC306929 DC345433 JF432808 ADZ16025 L13744 AAA58361 NM_001286691 NP_001273620 NM_004529 NP_004520
Function Component of the super elongation complex (SEC), a complex required to increase the catalytic rate of RNA polymerase II transcription by suppressing transient pausing by the polymerase at multiple sites along the DNA. {ECO:0000269|PubMed:20159561, ECO:0000269|PubMed:20471948}.
Subcellular Location Nucleus {ECO:0000255|PROSITE- ProRule:PRU00376}.
Top Pathways Transcriptional misregulation in cancer

AF9 (B-21) - sc-130681 from Santa Cruz Biotechnology

Prices $279.00
Sizes 100 µg/ml
Host Rabbit
Clonality Polyclonal
AF9 (B-21): sc-130681. Western blot analysis of AF9 expression in HL-60 whole cell lysate.

AF9 (D-17) - sc-32369 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

AF9 (L-15) - sc-32371 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
AF9 (L-15): sc-32371. Western blot analysis of AF9 expression in HL-60 (A), HeLa (B), K-562 (C) and NIH/3T3 (D) whole cell lysates and mouse testis tissue extract (E).

Anti-AF9 antibody - ab154492 from Abcam

Prices $384.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Anti-AF9 antibody (ab154492) at 1/1000 dilution + THP1 whole cell lysate at 30 µg

Anti-AF9 antibody - ab80558 from Abcam

Prices $384.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal

Anti-AF9 antibody - ab32719 from Abcam

Prices $359.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Anti-AF9 antibody (ab32719) at 1 µg/ml + Jurkat (Human T cell lymphoblast-like cell line) Whole Cell Lysate (ab7899) at 20 µgSecondaryIR Dye 680 Conjugated Goat Anti-Rabbit IgG (H+L) at 1/15000 dilutionPerformed under reducing conditions.

Anti-AF9 antibody - ab124626 from Abcam

Prices $376.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
ICC/IF image of ab124626 stained HepG2 cells. The cells were 100% methanol fixed (5 min) and then incubated in 1%BSA / 10% normal goat serum / 0.3M glycine in 0.1% PBS-Tween for 1h to permeabilise the cells and block non-specific protein-protein interactions. The cells were then incubated with the antibody ab124626 at 5µg/ml overnight at +4°C. The secondary antibody (green) was DyLight® 488 goat anti- rabbit (ab96899) IgG (H+L) used at a 1/250 dilution for 1h. Alexa Fluor® 594 WGA was used to label plasma membranes (red) at a 1/200 dilution for 1h. DAPI was used to stain the cell nuclei (blue) at a concentration of 1.43µM.

Anti-AF9 antibody - ab60083 from Abcam

Prices $359.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Ab60083 (1/50-1/100) staining human AF9 in human cancer tissue by immunohistochemistry using formalin fixed, paraffin embedded tissue. Formalin-fixed and paraffin-embedded human cancer tissue reacted with the primary antibody, which was peroxidase-conjugated to the secondary antibody, followed by AEC staining. HC = hepatocarcinoma.

Anti-AF9 antibody - ab71196 from Abcam

Prices $376.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
Anti-AF9 antibody (ab71196) at 1/100 dilution + mouse cerebellum tissue lysate at 12.5 µg

Anti-MLLT3 / AF9 Antibody (C-Terminus) - LS-C63788 from LifeSpan Bioscience

Prices $545.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-MLLT3 / AF9 Antibody (aa250-300) - LS-C63787 from LifeSpan Bioscience

Prices $545.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-MLLT3 / AF9 Antibody (aa479-509, AP) - LS-C250988 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-MLLT3 / AF9 Antibody (aa479-509, APC) - LS-C250989 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-MLLT3 / AF9 Antibody (aa479-509, Biotin) - LS-C250991 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-MLLT3 / AF9 Antibody (aa479-509, FITC) - LS-C250990 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-MLLT3 / AF9 Antibody (aa200-250) - LS-C287475 from LifeSpan Bioscience

Prices $375.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Anti-MLLT3 / AF9 Antibody (aa479-509, PE) - LS-C250993 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-MLLT3 / AF9 Antibody (aa479-509, Azide-free, HRP) - LS-C250992 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-MLLT3 / AF9 Antibody (N-Terminus) - LS-C80211 from LifeSpan Bioscience

Prices $365.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
HepG2 cell lysate. Antibody concentration: 1.0 ug/ml. Gel concentration: 12%.

Anti-MLLT3 / AF9 Antibody (aa479-509) - LS-C329204 from LifeSpan Bioscience

Prices $345.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-MLLT3 / AF9 Antibody (C-Terminus) - LS-C80212 from LifeSpan Bioscience

Prices $365.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
HepG2 cell lysate. Antibody concentration: 1.0 ug/ml. Gel concentration: 12%.

Anti-MLLT3 / AF9 Antibody (C-Terminus) - LS-C287479 from LifeSpan Bioscience

Prices $375.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Anti-MLLT3 / AF9 Antibody (aa250-300) - LS-C286395 from LifeSpan Bioscience

Prices $415.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Detection of Human AF9 by Immunohistochemistry. Sample: FFPE section of human ovarian carcinoma. Antibody: Affinity purified rabbit anti-AF9 used at a dilution of 1:250.

Anti-MLLT3 / AF9 Antibody (clone 3C11) - LS-C197688 from LifeSpan Bioscience

Prices $355.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone 3C11
Detection limit for recombinant GST tagged MLLT3 is approximately 3 ng/ml as a capture antibody.

Anti-MLLT3 / AF9 Antibody (aa471-502) - LS-C100430 from LifeSpan Bioscience

Prices $295.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
Formalin-fixed and paraffin-embedded human cancer tissue reacted with the primary antibody, which was peroxidase-conjugated to the secondary antibody, followed by AEC staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated. BC = breast carcinoma; HC = hepatocarcinoma.
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