Gene Symbol | MLLT3 |
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Entrez Gene | 4300 |
Alt Symbol | AF9, YEATS3 |
Species | Human |
Gene Type | protein-coding |
Description | myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 3 |
Other Description | ALL1-fused gene from chromosome 9 protein|YEATS domain-containing protein 3|myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog); translocated to, 3|myeloid/lymphoid or mixed-lineage leukemia translocated to chromosome 3 protein|protein AF-9 |
Swissprots | B7Z755 B2R7B3 D3DRJ8 P42568 Q8IVB0 B1AMQ2 |
Accessions | EAW58630 EAW58631 EAW58632 P42568 AK128222 AK225957 AK297587 BAH12621 AK301474 BAH13491 AK312914 BAG35760 AW451255 BC030550 BC036089 AAH36089 BI550359 BX649194 CAE46213 D16688 BAA04090 DC306929 DC345433 JF432808 ADZ16025 L13744 AAA58361 NM_001286691 NP_001273620 NM_004529 NP_004520 |
Function | Component of the super elongation complex (SEC), a complex required to increase the catalytic rate of RNA polymerase II transcription by suppressing transient pausing by the polymerase at multiple sites along the DNA. {ECO:0000269|PubMed:20159561, ECO:0000269|PubMed:20471948}. |
Subcellular Location | Nucleus {ECO:0000255|PROSITE- ProRule:PRU00376}. |
Top Pathways | Transcriptional misregulation in cancer |
AF9 CRISPR/Cas9 KO Plasmid (h) - sc-403805 from Santa Cruz Biotechnology
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AF9 HDR Plasmid (h) - sc-403805-HDR from Santa Cruz Biotechnology
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AF9 Double Nickase Plasmid (h) - sc-403805-NIC from Santa Cruz Biotechnology
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AF9 Double Nickase Plasmid (h2) - sc-403805-NIC-2 from Santa Cruz Biotechnology
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AF9 CRISPR Activation Plasmid (h) - sc-403805-ACT from Santa Cruz Biotechnology
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AF9 CRISPR Activation Plasmid (h2) - sc-403805-ACT-2 from Santa Cruz Biotechnology
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AF9 Lentiviral Activation Particles (h) - sc-403805-LAC from Santa Cruz Biotechnology
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AF9 Lentiviral Activation Particles (h2) - sc-403805-LAC-2 from Santa Cruz Biotechnology
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AF9 siRNA (h) - sc-44793 from Santa Cruz Biotechnology
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AF9 shRNA Plasmid (h) - sc-44793-SH from Santa Cruz Biotechnology
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AF9 shRNA (h) Lentiviral Particles - sc-44793-V from Santa Cruz Biotechnology
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MISSION® esiRNA - EHU074221 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN14404 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND14404 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR09684 from Sigma-Aldrich
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MLLT3 siRNA (Human) - CRH2918 from Cohesion Biosciences
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shRNA set against Human MLLT3 (NM_004529.2) - SHH342600 from Creative biogene
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shRNA set against Human MLLT3(NM_004529.2) - SHH192251 from Creative biogene
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Human MLLT3 siRNA - orb263420 from Biorbyt
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MLLT3 shRNA Plasmid (Human) - CHH2918 from Cohesion Biosciences
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MLLT3 miRNA 3'UTR clone - MiUTR1H-06329 from Creative biogene
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