| Gene Symbol |
MLLT3
|
| Entrez Gene |
4300
|
| Alt Symbol |
AF9, YEATS3
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 3
|
| Other Description |
ALL1-fused gene from chromosome 9 protein|YEATS domain-containing protein 3|myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog); translocated to, 3|myeloid/lymphoid or mixed-lineage leukemia translocated to chromosome 3 protein|protein AF-9
|
| Swissprots |
B7Z755 B2R7B3 D3DRJ8 P42568 Q8IVB0 B1AMQ2
|
| Accessions |
EAW58630 EAW58631 EAW58632 P42568 AK128222 AK225957 AK297587 BAH12621 AK301474 BAH13491 AK312914 BAG35760 AW451255 BC030550 BC036089 AAH36089 BI550359 BX649194 CAE46213 D16688 BAA04090 DC306929 DC345433 JF432808 ADZ16025 L13744 AAA58361 NM_001286691 NP_001273620 NM_004529 NP_004520
|
| Function |
Component of the super elongation complex (SEC), a complex required to increase the catalytic rate of RNA polymerase II transcription by suppressing transient pausing by the polymerase at multiple sites along the DNA. {ECO:0000269|PubMed:20159561, ECO:0000269|PubMed:20471948}.
|
| Subcellular Location |
Nucleus {ECO:0000255|PROSITE- ProRule:PRU00376}.
|
| Top Pathways |
Transcriptional misregulation in cancer
|
![Western Blot: AF9 Overexpression Lysate (Adult Normal) [NBL1-13137] Left-Empty vector transfected control cell lysate (HEK293 cell lysate); Right -Over-expression Lysate for AF9.](http://www.bioprodhub.com/system/product_images/cel_products/5/sub_1/8610_AF9%2520Overexpression%2520Lysate%2520%2528Adult%2520Normal%2529-Western%2520Blot-NBL1-13137-img0002.jpg)