Gene Symbol | NT5C |
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Entrez Gene | 30833 |
Alt Symbol | DNT, DNT1, HEL74, P5N2, PN-I, PN-II, UMPH2, cdN, dNT-1 |
Species | Human |
Gene Type | protein-coding |
Description | 5', 3'-nucleotidase, cytosolic |
Other Description | 5' nucleotidase, deoxy (pyrimidine), cytosolic type C|5'(3')-deoxyribonucleotidase, cytosolic type|cytosolic 5',3'-pyrimidine nucleotidase|deoxy-5'-nucleotidase 1|epididymis luminal protein 74|uridine 5'-monophosphate phosphohydrolase 2|uridine 5-prime monophosphate hydrolase 2 |
Swissprots | Q96HS6 Q8TCD5 Q9NP82 |
Accessions | DAA00070 EAW89241 EAW89242 EAW89243 Q8TCD5 AF154829 AAF36534 AK000419 BAA91151 BC002516 BC008183 AAH08183 BC017454 AAH17454 BC022334 AAH22334 BC047763 BG034032 BQ431723 BU627693 EU794640 ACJ13694 HQ448006 ADQ32487 XM_006721850 XP_006721913 XM_011524700 XP_011523002 XR_429885 NM_001252377 NP_001239306 NM_014595 NP_055410 NR_045513 |
Function | Dephosphorylates the 5' and 2'(3')-phosphates of deoxyribonucleotides, with a preference for dUMP and dTMP, intermediate activity towards dGMP, and low activity towards dCMP and dAMP. |
Subcellular Location | Cytoplasm. |
Tissue Specificity | Detected in skeletal muscle, heart and pancreas. {ECO:0000269|PubMed:10681516}. |
Top Pathways | Purine metabolism, Nicotinate and nicotinamide metabolism, Pyrimidine metabolism |
dNT-1 (F-9) - sc-271972 from Santa Cruz Biotechnology
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dNT-1 (H-48) - sc-292986 from Santa Cruz Biotechnology
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dNT-1 (C-20) - sc-18019 from Santa Cruz Biotechnology
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dNT-1 (L-17) - sc-18018 from Santa Cruz Biotechnology
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dNT-1 (C-10) - sc-390041 from Santa Cruz Biotechnology
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Anti-NT5C antibody - ab66977 from Abcam
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Anti-NT5C antibody - ab127921 from Abcam
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Anti-NT5C antibody - ab172498 from Abcam
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Anti-DNT / NT5C Antibody (C-Terminus) - LS-C146401 from LifeSpan Bioscience
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Anti-DNT / NT5C Antibody - LS-C155736 from LifeSpan Bioscience
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NT5C Antibody - NBP1-84564 from Novus Biologicals
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NT5C Antibody - NBP1-84563 from Novus Biologicals
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NT5C Antibody - H00030833-B01P from Novus Biologicals
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NT5C Antibody - NBP2-19596 from Novus Biologicals
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NT5C Antibody - H00030833-D01P from Novus Biologicals
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Anti-NT5C antibody produced in rabbit - SAB1410625 from Sigma-Aldrich
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Anti-NT5C antibody produced in mouse - SAB1400528 from Sigma-Aldrich
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Anti-NT5C antibody produced in rabbit - HPA023632 from Sigma-Aldrich
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Anti-NT5C antibody produced in rabbit - HPA021581 from Sigma-Aldrich
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NT5C antibody - C-terminal region (ARP39112_P050) - ARP39112_P050 from Aviva Systems Biology
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NT5C antibody - 16577-1-AP from Acris Antibodies
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NT5C antibody - H00030833-D01P from Acris Antibodies
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NT5C antibody - 16577-1-AP from Proteintech Group
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NT5C Antibody - GWB-MM967D from Genway Biotech
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Rabbit Anti-Human NT5C Polyclonal Antibody - DPABH-09905 from Creative Diagnostics
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