| Gene Symbol |
NT5C
|
| Entrez Gene |
30833
|
| Alt Symbol |
DNT, DNT1, HEL74, P5N2, PN-I, PN-II, UMPH2, cdN, dNT-1
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
5', 3'-nucleotidase, cytosolic
|
| Other Description |
5' nucleotidase, deoxy (pyrimidine), cytosolic type C|5'(3')-deoxyribonucleotidase, cytosolic type|cytosolic 5',3'-pyrimidine nucleotidase|deoxy-5'-nucleotidase 1|epididymis luminal protein 74|uridine 5'-monophosphate phosphohydrolase 2|uridine 5-prime monophosphate hydrolase 2
|
| Swissprots |
Q96HS6 Q8TCD5 Q9NP82
|
| Accessions |
DAA00070 EAW89241 EAW89242 EAW89243 Q8TCD5 AF154829 AAF36534 AK000419 BAA91151 BC002516 BC008183 AAH08183 BC017454 AAH17454 BC022334 AAH22334 BC047763 BG034032 BQ431723 BU627693 EU794640 ACJ13694 HQ448006 ADQ32487 XM_006721850 XP_006721913 XM_011524700 XP_011523002 XR_429885 NM_001252377 NP_001239306 NM_014595 NP_055410 NR_045513
|
| Function |
Dephosphorylates the 5' and 2'(3')-phosphates of deoxyribonucleotides, with a preference for dUMP and dTMP, intermediate activity towards dGMP, and low activity towards dCMP and dAMP.
|
| Subcellular Location |
Cytoplasm.
|
| Tissue Specificity |
Detected in skeletal muscle, heart and pancreas. {ECO:0000269|PubMed:10681516}.
|
| Top Pathways |
Purine metabolism, Nicotinate and nicotinamide metabolism, Pyrimidine metabolism
|