| Gene Symbol |
PHB2
|
| Entrez Gene |
11331
|
| Alt Symbol |
BAP, BCAP37, Bap37, PNAS-141, REA, p22
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
prohibitin 2
|
| Other Description |
B-cell associated protein|B-cell receptor-associated protein BAP37|D-prohibitin|prohibitin-2|repressor of estrogen receptor activity
|
| Swissprots |
Q7KYU3 B4DP75 Q99623 Q92978 Q2YDA4
|
| Accessions |
AAB51324 EAW88699 Q99623 AF126021 AAF17231 AF150962 AAD38042 AF178980 AAF44345 AF279895 AAK07552 AK298217 BAG60487 AK301316 BAG62867 BC013228 BC014766 AAH14766 BC110322 AAI10323 DQ891808 ABM82734 EU176626 ABW03427 U72511 AAC51639 U72512 XR_242980 NM_001144831 NP_001138303 NM_001267700 NP_001254629
|
| Function |
Acts as a mediator of transcriptional repression by nuclear hormone receptors via recruitment of histone deacetylases (By similarity). Functions as an estrogen receptor (ER)-selective coregulator that potentiates the inhibitory activities of antiestrogens and represses the activity of estrogens. Competes with NCOA1 for modulation of ER transcriptional activity. Probably involved in regulating mitochondrial respiration activity and in aging. {ECO:0000250|UniProtKB:O35129, ECO:0000269|PubMed:10359819, ECO:0000303|PubMed:11302691}.
|
| Subcellular Location |
Mitochondrion inner membrane {ECO:0000250}. Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}. Note=Also cytoplasmic and nuclear. {ECO:0000250}.
|
![Western Blot: Prohibitin 2 Overexpression Lysate (Adult Normal) [NBL1-14349] Left-Empty vector transfected control cell lysate (HEK293 cell lysate); Right -Over-expression Lysate for Prohibitin 2.](http://www.bioprodhub.com/system/product_images/cel_products/5/sub_2/6689_Prohibitin%25202%2520Overexpression%2520Lysate%2520(Adult%2520Normal)-Western%2520Blot-NBL1-14349-img0002.jpg)