| Gene Symbol |
JOSD1
|
| Entrez Gene |
9929
|
| Alt Symbol |
dJ508I15.2
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
Josephin domain containing 1
|
| Other Description |
Josephin-1|josephin domain-containing 1|josephin domain-containing protein 1
|
| Swissprots |
A8K712 Q15040
|
| Accessions |
EAW60259 EAW60260 Q15040 AK291827 BAF84516 BC015026 AAH15026 BX538323 CR456473 CAG30359 CR456923 CAG33204 CU013023 CAK54454 CU013311 CAK54753 D31884 BAA06682 XM_005261876 XP_005261933 XM_005261877 XP_005261934 XM_005261878 XP_005261935 XM_005261879 XP_005261936 NM_014876 NP_055691
|
| Function |
Deubiquitinates monoubiquitinated probes (in vitro). When ubiquitinated, cleaves 'Lys-63'-linked and 'Lys-48'-linked poly-ubiquitin chains (in vitro), hence may act as a deubiquitinating enzyme. May increase macropinocytosis and suppress clathrin- and caveolae-mediated endocytosis. May enhance membrane dynamics and cell motility independently of its catalytic activity. {ECO:0000269|PubMed:21118805, ECO:0000269|PubMed:23625928}.
|
| Subcellular Location |
Cell membrane {ECO:0000269|PubMed:23625928}. Cytoplasm {ECO:0000269|PubMed:23625928}. Note=Ubiquitination increases localization the plasma membrane. In the cytosol, the unubiquitinated form may be associated with the cytoskeleton via ACTB-binding.
|