Gene Symbol | JOSD1 |
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Entrez Gene | 9929 |
Alt Symbol | dJ508I15.2 |
Species | Human |
Gene Type | protein-coding |
Description | Josephin domain containing 1 |
Other Description | Josephin-1|josephin domain-containing 1|josephin domain-containing protein 1 |
Swissprots | A8K712 Q15040 |
Accessions | EAW60259 EAW60260 Q15040 AK291827 BAF84516 BC015026 AAH15026 BX538323 CR456473 CAG30359 CR456923 CAG33204 CU013023 CAK54454 CU013311 CAK54753 D31884 BAA06682 XM_005261876 XP_005261933 XM_005261877 XP_005261934 XM_005261878 XP_005261935 XM_005261879 XP_005261936 NM_014876 NP_055691 |
Function | Deubiquitinates monoubiquitinated probes (in vitro). When ubiquitinated, cleaves 'Lys-63'-linked and 'Lys-48'-linked poly-ubiquitin chains (in vitro), hence may act as a deubiquitinating enzyme. May increase macropinocytosis and suppress clathrin- and caveolae-mediated endocytosis. May enhance membrane dynamics and cell motility independently of its catalytic activity. {ECO:0000269|PubMed:21118805, ECO:0000269|PubMed:23625928}. |
Subcellular Location | Cell membrane {ECO:0000269|PubMed:23625928}. Cytoplasm {ECO:0000269|PubMed:23625928}. Note=Ubiquitination increases localization the plasma membrane. In the cytosol, the unubiquitinated form may be associated with the cytoskeleton via ACTB-binding. |
Active human JOSD1 full length protein - ab125847 from Abcam
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Human JOSD1 full length protein - ab134897 from Abcam
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JOSD1 protein (His-DHFR tag) - ab127601 from Abcam
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JOSD1 Antibody Blocking Peptide - LS-E25051 from LifeSpan Bioscience
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JOSD1 Antibody Blocking Peptide - LS-E25052 from LifeSpan Bioscience
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Josephin1 Recombinant Protein - H00009929-P01 from Novus Biologicals
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Recombinant Human Josephin1 Protein - NBP2-23156 from Novus Biologicals
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JOSD1-Antibody-C-term-Blocking-peptide - BP13392b from Abgent, a WuXi AppTec company
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Human JOSD1 protein - orb168683 from Biorbyt
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Human JOSD1 protein - orb244830 from Biorbyt
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JOSD1 protein (His tag) - 80R-2508 from Fitzgerald
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Josephin-1 / JOSD1 (1-202, His-tag) - AR50580PU-N from Acris Antibodies
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Josephin-1 / JOSD1 (1-202, His-tag) - AR50580PU-S from Acris Antibodies
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Josephin-1 / JOSD1 - H00009929-P01 from Acris Antibodies
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JOSD1, 1-202aa, Human, His tag, E.coli - 01-P1756 from ARP American Research Products
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JOSD1 Human - PRPS-1258 from NeoScientific
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JOSD1, 1-202aa, Recombinant Protein - GWB-P0282I from Genway Biotech
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Recombinant Human Josephin Domain Containing 1, His-tagged - JOSD1-7188H from Creative Biomart
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Recombinant Human JOSD1, His-tagged - JOSD1-175H from Creative Biomart
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Recombinant Human JOSD1, His-tagged - JOSD1-165H from Creative Biomart
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Recombinant Human Josephin-1(JOSD1) - CSB-YP624012HU CSB-BP624012HU CSB-MP624012HU from Cusabio
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Recombinant human Josephin-1 - CSB-EP624012HU from Cusabio
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JOSD1, 1-202aa, Human, His tag, E.coli - ATGP1756 from ATGen
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Josephin-1 / JOSD1 - TP301968 from Acris Antibodies
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Josephin1 Recombinant Protein Antigen - NBP1-87864PEP from Novus Biologicals
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